Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas.

abstract：:The role of stereotactic body radiation therapy (SBRT) in achieving durable local control and palliation of pain in pelvic lymph node oligometastatic disease is not well-studied. We performed a retrospective analysis of 30 patients with 43 pelvic lymph node oligometastases from various primary cancers all but one with...

journal_title：Cancer investigation

authors： Reshko LB,Richardson MK,Spencer K,Kersh CR

更新日期：2020-11-01 00:00:00

abstract：:Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis...

journal_title：Cancer investigation

authors： Rico MJ,Perroud HA,Mainetti LE,Rozados VR,Scharovsky OG

更新日期：2014-03-01 00:00:00

abstract：:To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...

journal_title：Cancer investigation

authors： Xiaojiang T,Jinsong Z,Jiansheng W,Chengen P,Guangxiao Y,Quanying W

更新日期：2010-06-01 00:00:00

abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...

journal_title：Cancer investigation

authors： Lei H,Tu Y,Yang L,Jin J,Luo H,Xu H,Kang J,Zhou L,Wu Y

更新日期：2019-01-01 00:00:00

abstract：:Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...

journal_title：Cancer investigation

authors： Hahm S,Dresner HS,Podwall D,Golden M,Winiarsky R,Moosikasuwan M,Cajigas A,Steinberg JJ

更新日期：2003-01-01 00:00:00

abstract：PURPOSE:The decision concerning adjuvant therapy remains difficult in patients with very early stage ovarian carcinomas [Fédération Internationale de Gynécologie et d' Obstétrique (FIGO) Ia/b]. Therefore, we compared the MIB1-determined tumor growth fraction in archival tumor tissue with tumor recurrence and outcome of...

journal_title：Cancer investigation

authors： Münstedt K,von Georgi R,Franke FE

更新日期：2004-01-01 00:00:00

abstract：:A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...

journal_title：Cancer investigation

authors： Scherbakov AM,Borunov AM,Buravchenko GI,Andreeva OE,Kudryavtsev IA,Dezhenkova LG,Shchekotikhin AE

更新日期：2018-03-16 00:00:00

abstract：:This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...

journal_title：Cancer investigation

authors： Beaven AW,Moore DT,Sharf A,Serody JS,Shea TC,Gabriel DA

更新日期：2011-03-01 00:00:00

abstract：:Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g...

journal_title：Cancer investigation

authors： Fahrmann JF,Ballester OF,Ballester G,Witte TR,Salazar AJ,Kordusky B,Cowen KG,Ion G,Primerano DA,Boskovic G,Denvir J,Hardman WE

更新日期：2013-01-01 00:00:00

abstract：:Although PKCs are assumed to be the main targets of phorbol esters (PMA), additional PMA effectors, such as chimaerins (a family of RacGTPase activating proteins) and RasGRP (exchange factor for Ras/Rap1), can counteract or strengthen the PKC pathways. In this study, we evaluated the proliferative behavior of PMA-trea...

journal_title：Cancer investigation

authors： Fortino V,Torricelli C,Capurro E,Sacchi G,Valacchi G,Maioli E

更新日期：2008-02-01 00:00:00

abstract：:The structural dimensions of capillary tight junctions and the uptake of 99mTc pertechnetate in human gliomas were studied. Quantitative analysis revealed a correlation between the uptake of radionuclides and the length of endothelial tight junctions. It is suggested that brain scintigraphy might be used for the selec...

journal_title：Cancer investigation

authors： Nir I,Kohn S,Doron Y,Israel O,Front D

更新日期：1986-01-01 00:00:00

abstract：:A Phase I trial of three carboplatin-based combination chemotherapy regimens was conducted. These included: carboplatin plus vindesine; carboplatin, vindesine, plus bleomycin; and, carboplatin plus vinblastine. Carboplatin was administered every 28 days as an intravenous bolus. The initial dose was 150 mg/m2 and doses...

journal_title：Cancer investigation

authors： Bajorin D,Kelsen DP

更新日期：1990-01-01 00:00:00

abstract：:Currently, bladder cancer ranks as the second most common genitourinary malignancy which is exacting significant morbidity and mortality worldwide. Although there are abundant epidemiological and basic studies which strongly suggest the role of androgen hormone in bladder cancer, the underlying mechanism is not fully ...

journal_title：Cancer investigation

authors： Wu J,Liu J,Jia R,Song H

更新日期：2013-12-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：:We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...

journal_title：Cancer investigation

authors： Chasseing NA,Barañao RI,Fernández O,Bordenave H,Rumi LS

更新日期：1993-01-01 00:00:00

abstract：:Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...

journal_title：Cancer investigation

authors： Bogush TA,Polezhaev BB,Mamichev IA,Bogush EA,Polotsky BE,Tjulandin SA,Ryabov AB

更新日期：2018-04-21 00:00:00

abstract：:Twenty four patients with epithelial ovarian cancer, who were treated by chemotherapy after debulking surgery, were monitored by serial monthly CA125 estimation and half-yearly computerized axial tomogram (CAT) of abdomen and pelvis. The efficiency of these monitoring methods and that of clinical examination were comp...

journal_title：Cancer investigation

authors： Ngan HY,Wong LC,Chan SY,Ma HK

更新日期：1990-01-01 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...

journal_title：Cancer investigation

authors： Feurino LW,Fisher WE,Bharadwaj U,Yao Q,Chen C,Li M

更新日期：2006-11-01 00:00:00

abstract：:The limited capacity to divide is one of the major differences between normal somatic cells and cancerous cells. This 'finite life span' of somatic cells is closely linked to loss of telomeric DNA at telomeres, the 'chromosome caps' consisting of repeated (7TAGGG) sequences., In more than 85% of advanced cancers, this...

journal_title：Cancer investigation

authors： Helder MN,Wisman GB,van der Zee GJ

更新日期：2002-01-01 00:00:00

abstract：:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...

journal_title：Cancer investigation

authors： Schattner EJ

更新日期：2002-01-01 00:00:00

abstract：PURPOSE:Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532, an inhibitor of telomerase on chondrosarcoma cells in vitro. METHODS:Telomerase activity, telomere lengths, growth kinetics and chemosensitivity were analyzed in...

journal_title：Cancer investigation

authors： Parsch D,Brassat U,Brümmendorf TH,Fellenberg J

更新日期：2008-07-01 00:00:00

abstract：:Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...

journal_title：Cancer investigation

authors： Lopez-Berestein G,Cabanillas F,Osborne BM,Libshitz HI,Bodey GP

更新日期：1983-01-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide and small cell lung cancer (SCLC) accounts for a significant proportion of all lung cancer cases. Even so, the underlying mechanism governing SCLC development remains poorly understood and SCLC related cancer death stands high despite decades of intensive inve...

journal_title：Cancer investigation

authors： Yang H,Luo J,Liu Z,Zhou R,Luo H

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...

journal_title：Cancer investigation

authors： Chang VT,Hwang SS,Kasimis B,Thaler HT

更新日期：2004-01-01 00:00:00

abstract：:Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, an...

journal_title：Cancer investigation

authors： Ali A,Kumar S,Kakaria VK,Mohan A,Luthra K,Upadhyay AD,Guleria R

更新日期：2017-07-03 00:00:00

abstract：:Between March 1986 and December 1987, two groups of consecutive patients with advanced breast cancer underwent epidoxorubicin (Epidx) monochemotherapy. Twenty-three patients (group A) received Epidx at a dose of 60 mg/m2 and 27 (group B) at a dose of 120 mg/m2 (i.v. every 3 weeks). No patient had undergone anthracycli...

journal_title：Cancer investigation

authors： Neri B,Pacini P,Algeri R,Lottini G,Rinaldini M,Tucci E,Pusterla R

更新日期：1993-01-01 00:00:00

abstract：:Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...

journal_title：Cancer investigation

authors： Shklar G,Oh SK

更新日期：2000-01-01 00:00:00

abstract：:The standard staging evaluation of prostate cancer includes digital rectal examination, measurement of serum tumor markers, radionuclide bone scan, and abdominal pelvic computed tomography (CT) or nuclear magnetic resonance imaging (MRI). We retrospectively reviewed 300 cases of newly diagnosed, untreated adenocarcino...

journal_title：Cancer investigation

authors： Huncharek M,Muscat J

更新日期：1995-01-01 00:00:00

abstract：:For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...

journal_title：Cancer investigation

authors： Tang SC

更新日期：2008-06-01 00:00:00

abstract：:Following is a review of altered fractionation in radiation therapy for head and neck cancer. The goals of altered fractionation are to increase local-regional control and/or reduce the risk of late complications. Altered fractionation schedules can be broadly classified as accelerated fractionation and hyperfractiona...

journal_title：Cancer investigation

authors： Mendenhall WM,Parsons JT

更新日期：1998-01-01 00:00:00