Antiproliferative and survival properties of PMA in MCF-7 breast cancer cell.

Abstract:

:Although PKCs are assumed to be the main targets of phorbol esters (PMA), additional PMA effectors, such as chimaerins (a family of RacGTPase activating proteins) and RasGRP (exchange factor for Ras/Rap1), can counteract or strengthen the PKC pathways. In this study, we evaluated the proliferative behavior of PMA-treated MCF-7 breast cancer cell and found that: PMA induced growth arrest and inhibited cell death; PMA activated ERKs, which, in turn, induced p21; and inhibitors of ERK (PD98059) and PKC (GF109203X) prevented p21 induction and abolished the PMA survival effect. We conclude that PMA inhibits MCF-7 cell growth and simultaneously stimulates cell survival; both responses are linked to ERK-dependent and p53-independent p21 induction.

journal_name

Cancer Invest

journal_title

Cancer investigation

authors

Fortino V,Torricelli C,Capurro E,Sacchi G,Valacchi G,Maioli E

doi

10.1080/07357900701637949

subject

Has Abstract

pub_date

2008-02-01 00:00:00

pages

13-21

issue

1

eissn

0735-7907

issn

1532-4192

pii

788770212

journal_volume

26

pub_type

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