Abstract:
BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 medical oncology patients who completed the MSAS-SF and the Functional Assessment Cancer Therapy (FACT-G) were analyzed. Canonical correlations were performed to assess the relationships of 32 MSAS-SF symptoms to quality of life (FACT-G domains) and clinical variables [age, Karnofsky performance status (KPS), stage of disease, and inpatient status]. The relation of the subscales of the Condensed MSAS (CMSAS) and FACT-G to survival was assessed in a multivariate model. RESULTS:The median age was 67 years (range, 20-89) and median KPS was 80% (range, 20-100). Primary sites were prostate in 141 (29%) patients, lung in 121 (26%) patients, colorectal in 53 (11%) patients, hematologic in 50 (10%) patients, head and neck in 30 (6%) patients and other in 84 (18%) patients. Median survival was 245 days (range, 1-2,215 days). Canonical correlation analyses identified a five-dimensional QOL factor structure. Symptoms important for QOL also correlated significantly with survival and provided the basis for the CMSAS with 14 symptoms and 3 subscales (CMSAS SUM, CMSAS PHYS, and CMSAS PSYCH). In multivariate analyses, the CMSAS PSYCH predicted survival independently of stage, performance status, and QOL. The CMSAS takes 2-4 minutes to complete. CONCLUSION:The CMSAS contains both QOL and survival information approximately equivalent to the original 32 items.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Chang VT,Hwang SS,Kasimis B,Thaler HTdoi
10.1081/cnv-200026487subject
Has Abstractpub_date
2004-01-01 00:00:00pages
526-36issue
4eissn
0735-7907issn
1532-4192journal_volume
22pub_type
杂志文章abstract::Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adu...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.654872
更新日期:2012-03-01 00:00:00
abstract::Endothelin-1 (ET-1) is a potent mitogen in various precursor tumor cells, including endometrial adenocarcinoma. It is proposed that ET-1 produced by endometrial adenocarcinoma may participate in the angiogenesis of this carcinoma in vivo. Endothelin converting enzyme-1 (ECE-1) is the key enzyme that synthesizes ET-1. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100107738
更新日期:2001-01-01 00:00:00
abstract::Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003630934
更新日期:2010-10-01 00:00:00
abstract::A randomized trial was conducted comparing ketoconazole and nystatin in the prevention of oral candidiasis and appearance of invasive fungal infections in 51 neutropenic leukemic patients undergoing induction chemotherapy. Ketoconazole was administered in a 200 mg dose twice daily. Nystatin oral suspension was given i...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-01-01 00:00:00
abstract::Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357907.2012.743553
更新日期:2013-01-01 00:00:00
abstract::Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039842
更新日期:1989-01-01 00:00:00
abstract::The limited capacity to divide is one of the major differences between normal somatic cells and cancerous cells. This 'finite life span' of somatic cells is closely linked to loss of telomeric DNA at telomeres, the 'chromosome caps' consisting of repeated (7TAGGG) sequences., In more than 85% of advanced cancers, this...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120000370
更新日期:2002-01-01 00:00:00
abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900902744494
更新日期:2010-03-01 00:00:00
abstract::After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500283101
更新日期:2005-01-01 00:00:00
abstract::To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...
journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2010-06-01 00:00:00
abstract::Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120001180
更新日期:2002-01-01 00:00:00
abstract::Standard chemotherapeutic regimens, such as cisplatin and etoposide, may improve quality of life and prolong survival in patients with incurable non-small cell lung cancer (NSCLC). This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stag...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357900009023055
更新日期:2000-01-01 00:00:00
abstract::Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909709039724
更新日期:1997-01-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100000069
更新日期:2001-01-01 00:00:00
abstract::Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1582060
更新日期:2019-01-01 00:00:00
abstract::In a sample of 633 US adult breast cancer survivors, we examined health-related worry as a function vulnerability as influenced by communication, trust, and planning with their cancer care team during the COVID-19 pandemic. We found significant positive correlations between communication and trust, communication and p...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1841220
更新日期:2021-01-01 00:00:00
abstract::A Phase I trial of three carboplatin-based combination chemotherapy regimens was conducted. These included: carboplatin plus vindesine; carboplatin, vindesine, plus bleomycin; and, carboplatin plus vinblastine. Carboplatin was administered every 28 days as an intravenous bolus. The initial dose was 150 mg/m2 and doses...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909009017558
更新日期:1990-01-01 00:00:00
abstract::Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077041
更新日期:1988-01-01 00:00:00
abstract::Cytosolic and nuclear progesterone receptor levels (RPC, RPN) were measured in normal and in pathological human endometria after single-dose progesterone injection 1-3 h before tissue collection (test subjects) and the results compared to those obtained in controls (no progesterone treatment). In test cases of late pr...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809082116
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abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024890
更新日期:1995-01-01 00:00:00
abstract::Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.732164
更新日期:2012-12-01 00:00:00
abstract::One of the hallmarks of cancer is limitless proliferative capacity, which is tightly associated with the ability to maintain telomeres. Over the last decade, the telomere biology of pediatric cancers has begun to be elucidated. Most pediatric leukemias and embryonal solid tumors activate the enzyme telomerase, a speci...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701208683
更新日期:2007-04-01 00:00:00
abstract::Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibition by tyrphostin AG1024 in the presence or absence of doxorubicin in a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.606252
更新日期:2011-10-01 00:00:00
abstract::In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.743557
更新日期:2013-01-01 00:00:00
abstract::Cisplatin (CDDP) was administered to a 49-year-old dialysis female patient with advanced uterine cervical cancer. Analysis of the pharmacokinetics of CDDP in the patient with renal failure and at hemodialysis were compared with that of patients without renal impairment. CDDP at 30 mg was administered by drip infusion....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109039874
更新日期:1991-01-01 00:00:00
abstract:BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701829777
更新日期:2008-04-01 00:00:00
abstract::We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.970193
更新日期:2014-12-01 00:00:00
abstract::Nature has provided many effective anticancer agents in current use, such as the microbially derived drugs; dactinomycin; bleomycin and doxorubicin; and the plant-derived drugs, vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents from natural sources continues through c...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::In this study, we evaluated SEA-H61D, a staphylococcal enterotoxin A mutant without emetic activity, as an antitumor agent in vitro and in vivo. It showed that SEA-H61D could significantly inhibit the growth of many cancer cell lines in vitro at very low concentrations by activating human peripheral blood mononuclear ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903286982
更新日期:2010-10-01 00:00:00
abstract::Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357900009023065
更新日期:2000-01-01 00:00:00