Chemiluminescence production by neutrophils and immune complex levels in cancer patients.

abstract：:Based on a preliminary trial that suggested that CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and PVB (cisplatinum, vinblastine, bleomycin), are at least partially non-cross-resistant, the Southwest Oncology Group treated patients with unfavorable histology, non-Hodgkin's lymphoma with CHOP and PVB. ...

journal_title：Cancer investigation

authors： Dabich L,Dahlberg S,Hartsock RJ,LoBuglio AF,Liepman MK,Grozea PN,Eyre HJ,Weick JK,Bonnet JD,Coltman CA Jr

更新日期：1991-01-01 00:00:00

abstract：:Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g...

journal_title：Cancer investigation

authors： Fahrmann JF,Ballester OF,Ballester G,Witte TR,Salazar AJ,Kordusky B,Cowen KG,Ion G,Primerano DA,Boskovic G,Denvir J,Hardman WE

更新日期：2013-01-01 00:00:00

abstract：:Cisplatin (CDDP) was administered to a 49-year-old dialysis female patient with advanced uterine cervical cancer. Analysis of the pharmacokinetics of CDDP in the patient with renal failure and at hemodialysis were compared with that of patients without renal impairment. CDDP at 30 mg was administered by drip infusion....

journal_title：Cancer investigation

authors： Tanabe N,Goto M,Morita H,Gotu T,Inagaki J,Yamanaki N,Kimura K

更新日期：1991-01-01 00:00:00

abstract：:The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk com...

journal_title：Cancer investigation

authors： Hamel PA,Hanley-Hyde J

更新日期：1997-01-01 00:00:00

abstract：:Doxorubicin and paclitaxel are highly active agents in the treatment of advanced breast cancer. Although early trials of the combination reported high response rates, an unexpectedly high incidence of congestive heart failure observed on two of the early trials was cause for much concern. More recently, clinical trial...

journal_title：Cancer investigation

authors： Perez EA

更新日期：2001-01-01 00:00:00

abstract：:IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infecti...

journal_title：Cancer investigation

authors： Mahanty S,Nutman TB

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:Patients with systemic malignancies have substantial quantities of tumor-specific DNA in their plasma which may serve as a potential biomarker for tumor burden. This approach has not been studied in gliomas. METHODS:Methylation specific polymerase chain reaction (MSP) was used to determine the methylation st...

journal_title：Cancer investigation

authors： Weaver KD,Grossman SA,Herman JG

更新日期：2006-02-01 00:00:00

abstract：:The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21...

journal_title：Cancer investigation

authors： Sapse DS,Tong Y,Bertino JR,Sapse AM

更新日期：1999-01-01 00:00:00

abstract：:Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated wi...

journal_title：Cancer investigation

authors： Yang Z,Ma J,Qi G,Zhang X

更新日期：2021-01-01 00:00:00

abstract：:Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...

journal_title：Cancer investigation

authors： Cho H,Lee YS,Kim J,Chung JY,Kim JH

更新日期：2013-11-01 00:00:00

abstract：:PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be ...

journal_title：Cancer investigation

authors： Engel RH,Brown JA,Von Roenn JH,O'Regan RM,Bergan R,Badve S,Rademaker A,Gradishar WJ

更新日期：2007-12-01 00:00:00

abstract：:Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis...

journal_title：Cancer investigation

authors： Rico MJ,Perroud HA,Mainetti LE,Rozados VR,Scharovsky OG

更新日期：2014-03-01 00:00:00

abstract：:Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...

journal_title：Cancer investigation

authors： Amirghofran Z,Bahmani M,Azadmehr A,Ashouri E,Javidnia K

更新日期：2007-10-01 00:00:00

abstract：:Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...

journal_title：Cancer investigation

authors： Jain S,Sengupta M,Jain P

更新日期：2019-01-01 00:00:00

abstract：:In conclusion, the prognosis for women with stage I borderline tumors is excellent. Surgery alone is the recommended treatment. For young patients, fertility-sparing surgery is optimal, with a small percentage eventually developing tumor in the contralateral ovary. For patients with advanced stage borderline tumors, 1...

journal_title：Cancer investigation

authors： Gershenson DM

更新日期：1999-01-01 00:00:00

abstract：:Primary squamous cell carcinoma of the breast is a rare clinical entity. We diagnosed a patient who presented with a pure squamous cell cancer of the breast 12 years after local radiation for a primary adenocarcinoma of breast. Previously reported cancers related to radiation of the breast have been squamous cell of s...

journal_title：Cancer investigation

authors： Singh H,Williams SP,Kinsella V,Lynch GR

更新日期：2000-01-01 00:00:00

abstract：:Computer visualization techniques (CVTs) are an emerging technology that can organize all cancer specialists. This article describes CVTs' ability to maximize the currently untapped advantages of intensity modulated radiotherapy (IMRT). The visual speed and dynamic strategies inherent in CVTs improves IMRT by distilli...

journal_title：Cancer investigation

authors： Butler EB,Shukla V,Paulino AC,Lu HH,Butler R,Smiedala M,Kurk J,Grant WH 3rd,McGary JE,Teh BS

更新日期：2007-02-01 00:00:00

abstract：:A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...

journal_title：Cancer investigation

authors： Scherbakov AM,Borunov AM,Buravchenko GI,Andreeva OE,Kudryavtsev IA,Dezhenkova LG,Shchekotikhin AE

更新日期：2018-03-16 00:00:00

abstract：:Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...

journal_title：Cancer investigation

authors： Zhou Y,Wang S,Yue BG,Gobl A,Oberg K

更新日期：2002-01-01 00:00:00

abstract：:The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...

journal_title：Cancer investigation

authors： Benner SE,Fetting JH,Brenner MH

更新日期：1994-01-01 00:00:00

abstract：:Cytosolic and nuclear progesterone receptor levels (RPC, RPN) were measured in normal and in pathological human endometria after single-dose progesterone injection 1-3 h before tissue collection (test subjects) and the results compared to those obtained in controls (no progesterone treatment). In test cases of late pr...

journal_title：Cancer investigation

authors： Gorodeski IG,Geier A,Lunenfeld B,Bahary CM

更新日期：1988-01-01 00:00:00

abstract：:The transforming growth factor beta 1 (TGF-beta1) is a multifunctional cytokine with several regulatory activities in tumor cells affecting growth, differentiation, and function. Alterations in gene expression, secretion, and regulation of TGF-beta1 may lead to a favorable environment for tumor development by angiogen...

journal_title：Cancer investigation

authors： Faria PC,Saba K,Neves AF,Cordeiro ER,Marangoni K,Freitas DG,Goulart LR

更新日期：2007-12-01 00:00:00

abstract：:Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors. This drug can be used either concomitantly with radiotherapy or as chemotherapy. The prognosis of relapsing medulloblastoma is poor and treatment is often difficult, especially after radiotherapy. Here, we report th...

journal_title：Cancer investigation

authors： Durando X,Thivat E,Gilliot O,Irthum B,Verrelle P,Vincent C,Bay JO

更新日期：2007-09-01 00:00:00

abstract：:This review summarizes the literature on QoL in early stage lung cancer patients who underwent surgery. PubMed and PsycINFO were searched. Twelve articles from 10 distinct studies were identified for a total of 992 patients. Five QoL measures were used. One study reported only on pre-surgical QoL, six only on post-sur...

journal_title：Cancer investigation

authors： Yip R,Taioli E,Schwartz R,Li K,Becker BJ,Tam K,Htwe YM,Yankelevitz DF,Henschke CI

更新日期：2018-01-01 00:00:00

abstract：:To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined the methylation status of 8 genes, including FLNC, EFS, ECRG4, RARB2, PITX2, GSTP1, PDLIM4, and KCNMA1 in 32 nonrecurrent, 32 recurrent primary prostate tumors, ...

journal_title：Cancer investigation

authors： Vanaja DK,Ehrich M,Van den Boom D,Cheville JC,Karnes RJ,Tindall DJ,Cantor CR,Young CY

更新日期：2009-06-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：:Arsenic trioxide is valuable for treatment of promyelocytic leukemia, but less attention has been paid to its therapeutic potential for other cancers. In this study, the effects of arsenic trioxide were tested in human pancreatic (AsPC-1), colonic (HT-29), and breast (MCF-7) cancer cells. In all three cancer cell line...

journal_title：Cancer investigation

authors： Li X,Ding X,Adrian TE

更新日期：2004-01-01 00:00:00

abstract：:The role of stereotactic body radiation therapy (SBRT) in achieving durable local control and palliation of pain in pelvic lymph node oligometastatic disease is not well-studied. We performed a retrospective analysis of 30 patients with 43 pelvic lymph node oligometastases from various primary cancers all but one with...

journal_title：Cancer investigation

authors： Reshko LB,Richardson MK,Spencer K,Kersh CR

更新日期：2020-11-01 00:00:00

abstract：:Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inherita...

journal_title：Cancer investigation

authors： Foroud T

更新日期：1997-01-01 00:00:00

abstract：:We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...

journal_title：Cancer investigation

authors： Moumtzi SS,Roberts ML,Joyce T,Evangelidou M,Probert L,Frillingos S,Fotsis T,Pintzas A

更新日期：2010-07-01 00:00:00