Comparative effectiveness of two metronomic chemotherapy schedules-our experience in the preclinical field.

abstract：:Malignant kidney tumors account for approximately 2% of all new primary cancer cases diagnosed in the United States, with an estimated 30,000 cases occurring annually. Although a variety of agents, chemical and biological, have been implicated as causal agents in the development of renal cell carcinoma (RCC), the etio...

journal_title：Cancer investigation

authors： Moore LE,Wilson RT,Campleman SL

更新日期：2005-01-01 00:00:00

abstract：:Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D...

journal_title：Cancer investigation

authors： Picotto G,Liaudat AC,Bohl L,Tolosa de Talamoni N

更新日期：2012-10-01 00:00:00

abstract：:In vivo and in vitro observations of cellular immune response in 70 patients with squamous cell cancer of the oral cavity and in 40 age-matched normal controls, were made using delayed hypersensitivity responses to DNCB, PPD, and Candida albicans extract (Dermatophytin 'O'), absolute lymphocyte counts, absolute T-cell...

journal_title：Cancer investigation

authors： Das SN,Khanna NN,Khanna S

更新日期：1986-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relative risk factor of food items for colorectal cancer in four time periods through a case-control study in a Chinese rural area. METHODS:Colorectal cancer patients diagnosed at a county cancer center, Hebei Province, China, and non-cancer outpatients with similar age, sex, and place of...

journal_title：Cancer investigation

authors： Zhang B,Li X,Nakama H,Zhang X,Wei N,Zhang X,Zhang L

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...

journal_title：Cancer investigation

authors： Chiou JF,Lin MC,Chen DR,Jim YF,Kao CH

更新日期：2003-01-01 00:00:00

abstract：:Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 i...

journal_title：Cancer investigation

authors： Tiscornia MM,González HS,Lorenzati MA,Zapata PD

更新日期：2015-03-01 00:00:00

abstract：:Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoke...

journal_title：Cancer investigation

authors： Moffat FL Jr,Gulec SA,Serafini AN,Sfakianakis GN,Pop R,Robinson DS,Franceschi D,Boggs J,Livingstone AS

更新日期：1999-01-01 00:00:00

abstract：:Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...

journal_title：Cancer investigation

authors： Tehan L,Taparra K,Phelan S

更新日期：2013-07-01 00:00:00

abstract：:A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR:...

journal_title：Cancer investigation

authors： Xie X,Liu J,Yang H,Chen H,Zhou S,Lin H,Liao Z,Ding Y,Ling L,Wang X

更新日期：2019-01-01 00:00:00

abstract：:To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...

journal_title：Cancer investigation

authors： Xiaojiang T,Jinsong Z,Jiansheng W,Chengen P,Guangxiao Y,Quanying W

更新日期：2010-06-01 00:00:00

abstract：:Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors), cholesterol-lowering agents widely prescribed for cardiovascular health, have been shown to exert several pleiotropic effects. Although some studies reported that statins have no effects on malignancies of any kind, results of several epidemiologic ...

journal_title：Cancer investigation

authors： Mannello F,Tonti GA

更新日期：2009-05-01 00:00:00

abstract：:Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...

journal_title：Cancer investigation

authors： Razis E,Karina M,Karanastassi S,Fountzilas G

更新日期：2006-08-01 00:00:00

abstract：:The limited capacity to divide is one of the major differences between normal somatic cells and cancerous cells. This 'finite life span' of somatic cells is closely linked to loss of telomeric DNA at telomeres, the 'chromosome caps' consisting of repeated (7TAGGG) sequences., In more than 85% of advanced cancers, this...

journal_title：Cancer investigation

authors： Helder MN,Wisman GB,van der Zee GJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from ...

journal_title：Cancer investigation

authors： Wirth MD,Burch JB,Hébert JR,Kowtal P,Mehrotra-Kapoor A,Steck SE,Hurley TG,Gupta PC,Pednekar MS,Youngstedt SD,Zhang H,Sarin R

更新日期：2014-08-01 00:00:00

abstract：:CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...

journal_title：Cancer investigation

authors： Voigt H,Vetter-Kauczok CS,Schrama D,Hofmann UB,Becker JC,Houben R

更新日期：2009-03-01 00:00:00

abstract：:To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 wee...

journal_title：Cancer investigation

authors： Case DC Jr,Coleman M,Gottlieb A,McCarroll K

更新日期：1992-01-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...

journal_title：Cancer investigation

authors： Bauer TM,Berlin JD

更新日期：2008-03-01 00:00:00

abstract：BACKGROUND:We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors. METHODS:From January 1998 to November 1999, we treated 28 patients on a phase I protocol with gemcitabine given at a constant dose of 800 mg/m2 i.v. ov...

journal_title：Cancer investigation

authors： Poole ME,Bernard SA,Churchel MA,Weissler MC,Calvo B,Cance W,Ollila D,Koruda M,Behrns K,Detterbeck FC

更新日期：2003-06-01 00:00:00

abstract：:This is a case report of small cell lung cancer (SCLC) that underwent spontaneous regression. This was associated with severe neuropathy, which was unresponsive to therapy, including corticosteroids and plasmapheresis. We present here the case report and a brief review of the literature. ...

journal_title：Cancer investigation

authors： Zaheer W,Friedland ML,Cooper EB,DoRosario A,Burd RM,Gagliardi J,Torstenson G

更新日期：1993-01-01 00:00:00

abstract：:High-dose acetaminophen (HDAC) produces hepatocellular necrosis and cytotoxic changes in other tissues that express mixed-function-oxidase (MFO) activity. N-acetylcysteine (NAC), administered within 8 hr of HDAC exposure, replenishes reduced glutathione and prevents these effects. Numerous cell culture and animal stud...

journal_title：Cancer investigation

authors： Kobrinsky NL,Hartfield D,Horner H,Maksymiuk A,Minuk GY,White DF,Feldstein TJ

更新日期：1996-01-01 00:00:00

abstract：:Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...

journal_title：Cancer investigation

authors： Jain S,Sengupta M,Jain P

更新日期：2019-01-01 00:00:00

abstract：:Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis...

journal_title：Cancer investigation

authors： Malaguarnera L,Pilastro MR,Vicari L,Dimarco R,Manzella L,Palumbo G,Messina A

更新日期：2005-01-01 00:00:00

abstract：:The overexpression of HER-2/neu and p53 has been associated with poor outcome in many neoplasms. Their role in patients with osteosarcoma is unclear. We studied the expression of HER-2/neu and p53 in 22 osteosarcoma samples (from 20 patients--2 had locally recurrent disease) biopsied at the University of Medicine and ...

journal_title：Cancer investigation

authors： Tsai JY,Aviv H,Benevenia J,Chang VT,Patterson F,Aisner S,Hameed M

更新日期：2004-01-01 00:00:00

abstract：:The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk com...

journal_title：Cancer investigation

authors： Hamel PA,Hanley-Hyde J

更新日期：1997-01-01 00:00:00

abstract：:Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m(2) every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well ...

journal_title：Cancer investigation

authors： Hainsworth JD,Meluch AA,Lane CM,Spigel DR,Burris HA 3rd,Gandhi JG,Crane EJ,Stipanov MA,Greco FA

更新日期：2010-03-01 00:00:00

abstract：:The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed ...

journal_title：Cancer investigation

authors： Viñolas N,Garrido P,Isla D,Provencio M,Majem M,Artal A,Carcereny E,Garcia Campelo R,Lianes P,De La Peñas R,Felip E

更新日期：2017-05-28 00:00:00

abstract：:Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...

journal_title：Cancer investigation

authors： Zakaria MA,Rajab NF,Chua EW,Selvarajah GT,Masre SF

更新日期：2020-09-01 00:00:00

abstract：:Fibronectin (Fn) synergizes with macrophages (M phi) in inducing cytostasis and cytotoxicity of neoplastic cells in culture. Since heparin enhances Fn's opsonic activity in many systems, we investigated its effect on Fn-macrophage synergy in cytostasis. MCG-T14 (a spontaneous mouse mammary adenocarcinoma) cells (4 X 1...

journal_title：Cancer investigation

authors： Martin DE,Reece M,Reese AC

更新日期：1984-01-01 00:00:00

abstract：:The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...

journal_title：Cancer investigation

authors： Limam S,Missaoui N,Hmissa S,Yacoubi MT,Krifa H,Mokni M,Selmi B

更新日期：2020-08-01 00:00:00

abstract：:This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...

journal_title：Cancer investigation

authors： Hardy WD Jr

更新日期：1983-01-01 00:00:00