Abstract:
:Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to increased tissue rigidity, promoting tumor growth by activating focal adhesion kinase (FAK) and Rho-associated kinase (ROCK). Consequently, result in recruitment of cancer-associated fibroblasts (CAFs), epithelial-mesenchymal transition (EMT) and tumor protection from immunosurveillance. We also discussed the rationale for targeting tumor tissue rigidity and its potential for cancer treatment.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Zakaria MA,Rajab NF,Chua EW,Selvarajah GT,Masre SFdoi
10.1080/07357907.2020.1802474subject
Has Abstractpub_date
2020-09-01 00:00:00pages
445-462issue
8-9eissn
0735-7907issn
1532-4192journal_volume
38pub_type
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