Examining ethical dilemmas as obstacles to hospice and palliative care for advanced cancer patients.

abstract：:Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...

journal_title：Cancer investigation

authors： Zhou Y,Wang S,Yue BG,Gobl A,Oberg K

更新日期：2002-01-01 00:00:00

abstract：:U-73,975 (U-73), U-77,779 (U-77), and U-80,244 (U-80) are analogs of the potent antitumor compound CC-1065. This class of drugs act as alkylating agents binding to DNA preferentially. Using the ATP-chemosensitivity assay, this study was designed to compare the potencies of U-73, U-77, and U-80 with cisplatin (DDP) or ...

journal_title：Cancer investigation

authors： Hightower RD,Sevin BU,Perras J,Nguyen H,Angioli R,Untch M,Averette H

更新日期：1993-01-01 00:00:00

abstract：:UFT is the combination of the fluorouracil (5-FU) prodrug tegafur, and the dihydrophyrimidine dehydrogenase inhibitor uracil. UFT and leucovorin have been used in the oral treatment of a variety of malignancies. Given the radiosensitizing properties of UFT, its combination with radiation therapy is a logical step in t...

journal_title：Cancer investigation

authors： Saad ED,Hoff PM

更新日期：2003-01-01 00:00:00

abstract：:Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis...

journal_title：Cancer investigation

authors： Rico MJ,Perroud HA,Mainetti LE,Rozados VR,Scharovsky OG

更新日期：2014-03-01 00:00:00

abstract：:The efficacy of dose-intense methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) chemotherapy relative to conventional-dose M-VAC in patients with advanced transitional cell carcinoma is unknown. The outcomes of 33 patients on two successive protocols using dose-intense M-VAC with granulocyte colony-stimulat...

journal_title：Cancer investigation

authors： Dodd PM,McCaffrey JA,Mazumdar M,Scher H,Higgins G,Boyle MG,Herr H,Bajorin DF

更新日期：2000-01-01 00:00:00

abstract：:Gefitinib (ZD1839, Iressa), a member of the 4-anilinoquinazoline class of compounds, has the chemical name 4-quinazolinamine, N-(3-chloro-4-flurophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]. Gefitinib often is referred to as a "specific" or "selective" inhibitor of epidermal growth factor receptor (EGFR). EGFR expre...

journal_title：Cancer investigation

authors： Freeman BB 3rd,Daw NC,Geyer JR,Furman WL,Stewart CF

更新日期：2006-04-01 00:00:00

abstract：:Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...

journal_title：Cancer investigation

authors： Zakaria MA,Rajab NF,Chua EW,Selvarajah GT,Masre SF

更新日期：2020-09-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide and small cell lung cancer (SCLC) accounts for a significant proportion of all lung cancer cases. Even so, the underlying mechanism governing SCLC development remains poorly understood and SCLC related cancer death stands high despite decades of intensive inve...

journal_title：Cancer investigation

authors： Yang H,Luo J,Liu Z,Zhou R,Luo H

更新日期：2015-04-01 00:00:00

abstract：:The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...

journal_title：Cancer investigation

authors： Rüschoff JH,Brandenburger T,Strehler EE,Filoteo AG,Heinmöller E,Aumüller G,Wilhelm B

更新日期：2012-05-01 00:00:00

abstract：:Nature has provided many effective anticancer agents in current use, such as the microbially derived drugs; dactinomycin; bleomycin and doxorubicin; and the plant-derived drugs, vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents from natural sources continues through c...

journal_title：Cancer investigation

authors： Cragg GM,Newman DJ

更新日期：1999-01-01 00:00:00

abstract：:Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...

journal_title：Cancer investigation

authors： Olsen RS,Dimberg J,Geffers R,Wågsäter D

更新日期：2019-01-01 00:00:00

abstract：:Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...

journal_title：Cancer investigation

authors： Xi J,Zeng ST,Guo L,Feng J

更新日期：2016-01-01 00:00:00

abstract：:The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was c...

journal_title：Cancer investigation

authors： Chaudhry P,Srinivasan R,Patel FD

更新日期：2009-10-01 00:00:00

abstract：:ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...

journal_title：Cancer investigation

authors： Qu H,Qu D,Chen F,Zhang Z,Liu B,Liu H

更新日期：2010-07-01 00:00:00

abstract：:Enhanced proteolysis and altered tight junction (TJ) proteins associate with carcinoma invasion. We hypothesized that trypsin-2, a tumor-associated serine proteinase, induces tongue carcinoma invasion by activating pro-membrane type-1 matrix metalloproteinase (MT1-MMP) and disturbing the TJs. The effects of invasion w...

journal_title：Cancer investigation

authors： Vilen ST,Suojanen J,Salas F,Risteli J,Ylipalosaari M,Itkonen O,Koistinen H,Baumann M,Stenman UH,Sorsa T,Salo T,Nyberg P

更新日期：2012-10-01 00:00:00

abstract：:The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...

journal_title：Cancer investigation

authors： Limam S,Missaoui N,Hmissa S,Yacoubi MT,Krifa H,Mokni M,Selmi B

更新日期：2020-08-01 00:00:00

abstract：:Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...

journal_title：Cancer investigation

authors： Jasin M

更新日期：2000-01-01 00:00:00

abstract：:In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...

journal_title：Cancer investigation

authors： Chen J,Chen Y,Chen Z

更新日期：2013-01-01 00:00:00

abstract：:We studied the effects of Shikaron, which is composed of 8 Chinese herb extracts, on carcinogenesis and the cytotoxic activity and cytokine production of lymphocytes in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine (BBN). We found a significantly lower incidence of urinary bladder carcinoma in mice tr...

journal_title：Cancer investigation

authors： Kurashige S,Jin R,Akuzawa Y,Endo F

更新日期：1998-01-01 00:00:00

abstract：:Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...

journal_title：Cancer investigation

authors： Gazitt Y,Gurfel D,Leizerowitz R,Feinstein H,Polliack A

更新日期：1987-01-01 00:00:00

abstract：:Human mesenchymal stem cells (hMSCs) play an important role in the development of human cancers. In the present study, we observed that hMSCs promoted human prostate cancer (PCa) cell PC-3 growth in vivo and in vitro. The conditional medium of hMSCs promoted the proliferation, migration, and invasion of PC-3 cells. Th...

journal_title：Cancer investigation

authors： Ye H,Cheng J,Tang Y,Liu Z,Xu C,Liu Y,Sun Y

更新日期：2012-08-01 00:00:00

abstract：BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...

journal_title：Cancer investigation

authors： Anders C,Marcom PK,Peterson B,Gu L,Unruhe S,Welch R,Lyons P,Behera M,Copland S,Kimmick G,Shaw H,Snyder S,Antenos M,Woodruff T,Blackwell K

更新日期：2008-04-01 00:00:00

abstract：:IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infecti...

journal_title：Cancer investigation

authors： Mahanty S,Nutman TB

更新日期：1993-01-01 00:00:00

abstract：:Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...

journal_title：Cancer investigation

authors： Modak S,Cheung NK

更新日期：2007-02-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...

journal_title：Cancer investigation

authors： Bauer TM,Berlin JD

更新日期：2008-03-01 00:00:00

abstract：:The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...

journal_title：Cancer investigation

authors： Shang D,Yang P,Liu Y,Song J,Zhang F,Tian Y

更新日期：2011-06-01 00:00:00

abstract：:Although PKCs are assumed to be the main targets of phorbol esters (PMA), additional PMA effectors, such as chimaerins (a family of RacGTPase activating proteins) and RasGRP (exchange factor for Ras/Rap1), can counteract or strengthen the PKC pathways. In this study, we evaluated the proliferative behavior of PMA-trea...

journal_title：Cancer investigation

authors： Fortino V,Torricelli C,Capurro E,Sacchi G,Valacchi G,Maioli E

更新日期：2008-02-01 00:00:00

abstract：:Several studies have shown that sera from patients with Hodgkin's disease contain factors capable of inhibiting polymorphonuclear functions, among them chemotaxis. In the present study, we investigated whether these sera, which were able to inhibit PMN chemotaxis in the agarose test, were also able to affect the 3H-NE...

journal_title：Cancer investigation

authors： Polidori R,Tacchi P,Azzará A,Martini C,Lucacchini A,Ferrara MP,Ambrogi F

更新日期：1994-01-01 00:00:00

abstract：:In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor ti...

journal_title：Cancer investigation

authors： Singh N,Das P,Datta Gupta S,Sahni P,Pandey RM,Gupta S,Chauhan SS,Saraya A

更新日期：2013-08-01 00:00:00

abstract：:Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...

journal_title：Cancer investigation

authors： Tian F,Wu H,Li Z,Wang N,Huang J,Li C,Xie F

更新日期：2009-08-01 00:00:00