Abstract:
:Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that the CD133-negative subpopulation exhibited enhanced growth and hyperphosphorylation of AKT. Treatment of Akt inhibitor suppressed the cell growth of CD133-negative subpopulation to the levels of CD133-positive cells. These results suggest that CD133 has negative effect on the growth of cells through AKT-dependent signalling pathway.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Kimura T,Wang L,Tabu K,Nishihara H,Mashita Y,Kikuchi N,Tanino M,Hiraga H,Tanaka Sdoi
10.3109/07357907.2012.672607subject
Has Abstractpub_date
2012-06-01 00:00:00pages
390-7issue
5eissn
0735-7907issn
1532-4192journal_volume
30pub_type
杂志文章abstract::Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...
journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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abstract::This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...
journal_title:Cancer investigation
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更新日期:2017-07-03 00:00:00
abstract::The role of tyrosine kinase inhibitors (TKIs) in the treatment of advanced malignancies is well established. Imatinib and vatalanib are oral TKIs with different mechanisms of action. This trial sought to establish the safety, tolerability, and maximum tolerated dose (MTD) of the two agents in combination. Secondary ob...
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journal_title:Cancer investigation
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journal_title:Cancer investigation
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abstract:UNLABELLED:The effect of castration on the incorporation of [35S]methionine into secreted proteins in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors, was investigated. Biopsy specimens were obtained from 19 tumors, 0, 24, 48, 72, and 96 h after castration. In 14 tumors, castration induced an increase ...
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journal_title:Cancer investigation
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更新日期:1995-01-01 00:00:00
abstract::Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...
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pub_type: 临床试验,杂志文章
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