A phase II study of single agent bortezomib in patients with metastatic breast cancer: a single institution experience.


:PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be effective in solid tumors, one of which was breast cancer. We conducted a single institution, phase II study using PS-341 in the treatment of patients with metastatic breast cancer. The primary objective of this study was to determine the objective tumor response in patients with metastatic breast cancer (MBC) receiving PS-341. The secondary objectives were to estimate progression-free survival of patients receiving single-agent PS-341 and to evaluate toxicity related to PS-341. In all 12 patients who met criteria for enrollment, there were no observed objective responses. Further, all 12 patients progressed while receiving therapy with PS-341. This study was terminated after the first stage due to the lack of any objective response.


Cancer Invest


Cancer investigation


Engel RH,Brown JA,Von Roenn JH,O'Regan RM,Bergan R,Badve S,Rademaker A,Gradishar WJ




Has Abstract


2007-12-01 00:00:00














  • Antitumor and Antiangiogenic Activities of Lenvatinib in Mouse Xenograft Models of Vascular Endothelial Growth Factor-Induced Hypervascular Human Hepatocellular Carcinoma.

    abstract::High expression of vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma (HCC) is associated with poor prognosis. Here, we investigated the antitumor activity of lenvatinib, a multiple receptor tyrosine kinase inhibitor, in VEGF-overexpressing HCC models. In human umbilical vein endotheli...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Adachi Y,Matsuki M,Watanabe H,Takase K,Kodama K,Matsui J,Funahashi Y,Nomoto K

    更新日期:2019-01-01 00:00:00

  • Immunoregulation of murine plasmacytoma. II. Target selectivity of anomalous killer cells and role of immune T cells for the induction.

    abstract::Requirements for the induction of anomalous killer (AK) cells to syngeneic MOPC 104E-KI81 plasmacytoma, and their pattern of reaction were investigated. The AK cells are Thy-1.2 positive and were induced by cocultivation of normal BALB/c spleen cells for 5 days in vitro with mitomycin C-treated MOPC 104E-KI81 cells in...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Hayashida I,Hiramoto RN,Shrestha K,Ghanta VK

    更新日期:1989-01-01 00:00:00

  • Phase II trial of paclitaxel in patients with soft-tissue sarcoma.

    abstract::The response rate (RR) to single-agent chemotherapy with doxorubicin or ifosfamide in patients with advanced soft-tissue sarcoma (STS) is in the range of 20%. Paclitaxel is clinically useful in treating several solid tumors and has demonstrated activity in a series of human sarcoma cell lines. Twenty-eight patients wi...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章


    authors: Casper ES,Waltzman RJ,Schwartz GK,Sugarman A,Pfister D,Ilson D,Woodruff J,Leung D,Bertino JR

    更新日期:1998-01-01 00:00:00

  • Alternated versus syncopated CHOP-PVB: two studies for the treatment of non-Hodgkin's lymphoma by the Southwest Oncology Group.

    abstract::Based on a preliminary trial that suggested that CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and PVB (cisplatinum, vinblastine, bleomycin), are at least partially non-cross-resistant, the Southwest Oncology Group treated patients with unfavorable histology, non-Hodgkin's lymphoma with CHOP and PVB. ...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Dabich L,Dahlberg S,Hartsock RJ,LoBuglio AF,Liepman MK,Grozea PN,Eyre HJ,Weick JK,Bonnet JD,Coltman CA Jr

    更新日期:1991-01-01 00:00:00

  • Growth arrest in ovarian cancer cells by hTERT inhibition short-hairpin RNA targeting human telomerase reverse transcriptase induces immediate growth inhibition but not necessarily induces apoptosis in ovarian cancer cells.

    abstract::It is believed that telomerase is a terminal effector and its role is to maintain the length of telomeres. However, the main rate-limiting subunit of telomerase, human telomerase reverse transcriptase (hTERT), has been recently proved to have the ability to affect a variety of other genes such as p53 independently of ...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Luo Y,Yi Y,Yao Z

    更新日期:2009-12-01 00:00:00

  • In vivo and in vitro observation of cellular immune parameters in squamous cell carcinoma of the oral cavity and its correlation with tumor load and prognosis.

    abstract::In vivo and in vitro observations of cellular immune response in 70 patients with squamous cell cancer of the oral cavity and in 40 age-matched normal controls, were made using delayed hypersensitivity responses to DNCB, PPD, and Candida albicans extract (Dermatophytin 'O'), absolute lymphocyte counts, absolute T-cell...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Das SN,Khanna NN,Khanna S

    更新日期:1986-01-01 00:00:00

  • Digital dermatoglyphics in mammary cancer.

    abstract::Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Bierman HR,Faith MR,Stewart ME

    更新日期:1988-01-01 00:00:00

  • Developments in epidermal growth factor receptor-targeting therapy for solid tumors: focus on matuzumab (EMD 72000).

    abstract::Expression of epidermal growth factor and its transmembrane receptor (EGFR) stimulates tumor growth. Matuzumab is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth, and provides a clinical benefit for some patients. The plasma half-life (6-10 days) an...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Schiller JH

    更新日期:2008-02-01 00:00:00

  • Tumor-infiltrating lymphocytes predict response to neoadjuvant chemotherapy in patients with breast carcinoma.

    abstract::Tumor-infiltrating leukocytes and other immunohistochemical parameters were evaluated in pretherapeutic biopsies and resection specimens in 73 patients undergoing neoadjuvant chemotherapy with doxorubicin and paclitaxel. Ten patients with pathological complete response had significantly higher p53 expression, CD3(+) l...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Hornychova H,Melichar B,Tomsova M,Mergancova J,Urminska H,Ryska A

    更新日期:2008-12-01 00:00:00

  • Reversible deficiency of serum high density lipoproteins in Hodgkin's disease.

    abstract::An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Herbert PN,Friedland ML

    更新日期:1986-01-01 00:00:00

  • Possible risk modification by polymorphisms of estrogen metabolizing genes in familial breast cancer susceptibility in an Indian population.

    abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

    更新日期:2010-03-01 00:00:00

  • An analog of withaferin A activates the MAPK and glutathione "stress" pathways and inhibits pancreatic cancer cell proliferation.

    abstract::Withaferin A (WA) (1) and two analogs [4-epi-withaferin A (2) and 4,27-diacetyl-4-epi-withaferin A (3)] were evaluated for antitumor activity in pancreatic cancer cells. IC(50) for 1, 2, and 3 were 0.87, 0.45, and 0.29 ?M (BxPC-3); 1.28, 1.53, and 0.52 ?M (MIAPaCa-2); and 0.59, 2.25, and 0.56 ?M (PANC-1), respectively...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Liu X,Qi W,Cooke LS,Kithsiri Wijeratne EM,Xu YM,Marron MT,Leslie Gunatilaka AA,Mahadevan D

    更新日期:2011-12-01 00:00:00

  • Examining ethical dilemmas as obstacles to hospice and palliative care for advanced cancer patients.

    abstract::Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Daugherty CK

    更新日期:2004-01-01 00:00:00

  • Macrophages and tumor growth. II. Cell kinetics at the site of allogeneic tumor growth.

    abstract::The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Barrera CN,Mazzolli AB,Bustuoabad OD,Andreetta AM,Pasqualini CD

    更新日期:1985-01-01 00:00:00

  • Improved response by co-targeting EGFR/EGFRvIII and Src family kinases in human cancer cells.

    abstract::We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Andersen P,Villingshøj M,Poulsen HS,Stockhausen MT

    更新日期:2009-02-01 00:00:00

  • Corticosteroids in cancer: neuropsychiatric complications.

    abstract::The addition of corticosteroids in the early 1950s to the treatment armamentarium provided cure of some diseases and control of many. They have become an integral part of many cancer treatment regimens. Early reports of severe affective disorders appear less frequent today in patients receiving steroids, though contro...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Stiefel FC,Breitbart WS,Holland JC

    更新日期:1989-01-01 00:00:00

  • A randomized trial comparing ketoconazole and nystatin prophylactic therapy in neutropenic patients.

    abstract::A randomized trial was conducted comparing ketoconazole and nystatin in the prevention of oral candidiasis and appearance of invasive fungal infections in 51 neutropenic leukemic patients undergoing induction chemotherapy. Ketoconazole was administered in a 200 mg dose twice daily. Nystatin oral suspension was given i...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Vogler WR,Malcom LG,Winton EF

    更新日期:1987-01-01 00:00:00

  • Quantitative analysis of tight junctions and the uptake of 99mTc in human gliomas.

    abstract::The structural dimensions of capillary tight junctions and the uptake of 99mTc pertechnetate in human gliomas were studied. Quantitative analysis revealed a correlation between the uptake of radionuclides and the length of endothelial tight junctions. It is suggested that brain scintigraphy might be used for the selec...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Nir I,Kohn S,Doron Y,Israel O,Front D

    更新日期:1986-01-01 00:00:00

  • A novel 3-d model of chick chorioallantoic membrane for ameliorated studies in angiogenesis.

    abstract::Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Ejaz S,Chekarova I,Ashraf M,Lim CW

    更新日期:2006-10-01 00:00:00

  • Combination of 5-fluorouracil and cyclophosphamide in L1210 and P388 leukemias with changes in optimum treatments as a function of the age of the L1210 tumor at first treatment.

    abstract::The interaction of 5-fluorouracil and cyclophosphamide in the treatment of L1210 and P388 leukemias was studied using response surface methodology. Single dose treatment of each drug was administered simultaneously or with a 24-hr interval between 5-fluorouracil and cyclophosphamide to the advanced tumors or at variou...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Wampler GL,Carter WH Jr,Campbell ED

    更新日期:1987-01-01 00:00:00

  • Inhibition of tumor progression and paraneoplastic syndrome development in a murine lung adenocarcinoma by medroxyprogesterone acetate and indomethacin.

    abstract::Mice bearing LP07 lung adenocarcinoma present some characteristics similar to those shown in patients with several malignant diseases. LP07 tumor bearers develop paraneoplastic syndromes such as cachexia, leukocytosis, and hypercalcemia, partly due to a systemic inflammatory response. We analyzed some of the mechanism...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Diament MJ,Peluffo GD,Stillitani I,Cerchietti LC,Navigante A,Ranuncolo SM,Klein SM

    更新日期:2006-03-01 00:00:00

  • Spontaneous regression of small cell carcinoma of lung associated with severe neuropathy.

    abstract::This is a case report of small cell lung cancer (SCLC) that underwent spontaneous regression. This was associated with severe neuropathy, which was unresponsive to therapy, including corticosteroids and plasmapheresis. We present here the case report and a brief review of the literature. ...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Zaheer W,Friedland ML,Cooper EB,DoRosario A,Burd RM,Gagliardi J,Torstenson G

    更新日期:1993-01-01 00:00:00

  • Effect of plasma fibronectin, macrophages, and glycosaminoglycans on tumor cell growth.

    abstract::Fibronectin (Fn) synergizes with macrophages (M phi) in inducing cytostasis and cytotoxicity of neoplastic cells in culture. Since heparin enhances Fn's opsonic activity in many systems, we investigated its effect on Fn-macrophage synergy in cytostasis. MCG-T14 (a spontaneous mouse mammary adenocarcinoma) cells (4 X 1...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Martin DE,Reece M,Reese AC

    更新日期:1984-01-01 00:00:00

  • Plasma membrane calcium ATPase expression in human colon multistep carcinogenesis.

    abstract::The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Rüschoff JH,Brandenburger T,Strehler EE,Filoteo AG,Heinmöller E,Aumüller G,Wilhelm B

    更新日期:2012-05-01 00:00:00

  • Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients.

    abstract::Gefitinib (ZD1839, Iressa), a member of the 4-anilinoquinazoline class of compounds, has the chemical name 4-quinazolinamine, N-(3-chloro-4-flurophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]. Gefitinib often is referred to as a "specific" or "selective" inhibitor of epidermal growth factor receptor (EGFR). EGFR expre...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Freeman BB 3rd,Daw NC,Geyer JR,Furman WL,Stewart CF

    更新日期:2006-04-01 00:00:00

  • Could concomitant radio-chemotherapy improve the outcomes of early-stage node negative anal canal cancer patients? A retrospective analysis of 122 patients.

    abstract::One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved loc...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: De Bari B,Lestrade L,Pommier P,Maddalo M,Buglione M,Magrini SM,Carrie C

    更新日期:2015-04-01 00:00:00

  • Symptomatic acute mucositis can be minimized or prophylaxed by the combination of sucralfate and fluconazole.

    abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Allison RR,Vongtama V,Vaughan J,Shin KH

    更新日期:1995-01-01 00:00:00

  • Reducing the risk of distant metastases: a better end point in adjuvant aromatase inhibitor breast cancer trials?

    abstract::For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Tang SC

    更新日期:2008-06-01 00:00:00

  • Serum prostate-specific antigen as a predictor of radiographic staging studies in newly diagnosed prostate cancer.

    abstract::The standard staging evaluation of prostate cancer includes digital rectal examination, measurement of serum tumor markers, radionuclide bone scan, and abdominal pelvic computed tomography (CT) or nuclear magnetic resonance imaging (MRI). We retrospectively reviewed 300 cases of newly diagnosed, untreated adenocarcino...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Huncharek M,Muscat J

    更新日期:1995-01-01 00:00:00

  • Leukemic stem cells: a review.

    abstract::A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: O'Brien JA,Rizzieri DA

    更新日期:2013-05-01 00:00:00