Decreased expression and aberrant methylation of Raf kinase inhibitory protein gene in esophageal squamous cell carcinoma.

Abstract:

:Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition of TE-13 cell proliferation. The promoter hypermethylation of RKIP was found to occur in dysplastic tissues and a close correlation was noted between RKIP methylation and the loss of mRNA and protein expression of the gene in ESCC specimens. In summary, RKIP may act as a tumor suppressor gene in esophageal cancer.

journal_name

Cancer Invest

journal_title

Cancer investigation

authors

Guo W,Dong Z,Lin X,Zhang M,Kuang G,Zhu T

doi

10.3109/07357907.2012.732164

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

703-11

issue

10

eissn

0735-7907

issn

1532-4192

journal_volume

30

pub_type

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