Evaluation of Cytotoxic Potentials of Novel Cyclooxygenase-2 Inhibitor against ALL Lymphocytes and Normal Lymphocytes and Its Anticancer Effect through Mitochondrial Pathway.

abstract：:Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...

journal_title：Cancer investigation

authors： Cascinu S,Del Ferro E,Ligi M,Staccioli MP,Giordani P,Catalano V,Agostinelli R,Muretto P,Catalano G

更新日期：2001-01-01 00:00:00

abstract：:The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...

journal_title：Cancer investigation

authors： Rüschoff JH,Brandenburger T,Strehler EE,Filoteo AG,Heinmöller E,Aumüller G,Wilhelm B

更新日期：2012-05-01 00:00:00

abstract：:For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...

journal_title：Cancer investigation

authors： Tang SC

更新日期：2008-06-01 00:00:00

abstract：:N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...

journal_title：Cancer investigation

authors： Pergolizzi RG,Kreis W,Rottach C,Susin M,Broome JD

更新日期：1993-01-01 00:00:00

abstract：:Hepatitis B virus X protein (HBx) promotes hepatocellular carcinoma (HCC) invasion and metastasis by a poorly understood mechanism. This study investigated the role of NF-kappa B in HBx-mediated upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). In a stably expressing HBx c...

journal_title：Cancer investigation

authors： Liu LP,Liang HF,Chen XP,Zhang WG,Yang SL,Xu T,Ren L

更新日期：2010-06-01 00:00:00

abstract：:Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis...

journal_title：Cancer investigation

authors： Malaguarnera L,Pilastro MR,Vicari L,Dimarco R,Manzella L,Palumbo G,Messina A

更新日期：2005-01-01 00:00:00

abstract：:Until recently physicians have been reluctant to disclose a poor prognosis to patients for fear of harming them with the bad news and/or taking away their will to live. In the last decades we have seen a reversal of practice among Western physicians, and most doctors readily disclose to their patients the full extant ...

journal_title：Cancer investigation

authors： Jotkowitz A,Glick S,Gezundheit B

更新日期：2006-12-01 00:00:00

abstract：:Enhancement of radiation injury to the skin and mucous membranes has been observed with a number of chemotherapeutic agents. A 32-year-old woman with metastatic breast cancer received local radiation therapy to the lumbosacral area. Six weeks later, systemic edatrexate therapy was initiated and a localized painful ery...

journal_title：Cancer investigation

authors： Perez EA,Campbell DL,Ryu JK

更新日期：1995-01-01 00:00:00

abstract：:A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA m...

journal_title：Cancer investigation

authors： Copeland WC,Wachsman JT,Johnson FM,Penta JS

更新日期：2002-01-01 00:00:00

abstract：:The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for ...

journal_title：Cancer investigation

authors： Retsky MW,Swartzendruber DE,Bame PD,Wardwell RH

更新日期：1994-01-01 00:00:00

abstract：:Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...

journal_title：Cancer investigation

authors： Frytak S,Lee RE,Pairolero PC,Arnold PG,Shaw JN

更新日期：1988-01-01 00:00:00

abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...

journal_title：Cancer investigation

authors： Lei H,Tu Y,Yang L,Jin J,Luo H,Xu H,Kang J,Zhou L,Wu Y

更新日期：2019-01-01 00:00:00

abstract：:Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...

journal_title：Cancer investigation

authors： Brenner PR

更新日期：1997-01-01 00:00:00

abstract：:Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cell lymphoma tumor progression model. We compared these features and th...

journal_title：Cancer investigation

authors： Donin N,Kay S,Sinai J,Katzenelson D,Siegal A,Michowitz M,Schibi G,Leibovici J

更新日期：2000-01-01 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...

journal_title：Cancer investigation

authors： Feurino LW,Fisher WE,Bharadwaj U,Yao Q,Chen C,Li M

更新日期：2006-11-01 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：:Here 145 reported post-splenectomy infections in 115 patients with Hodgkin's disease are reviewed. Such infections can occur at any age (median age 19.8 years) and the interval from splenectomy to the infection is quite variable (median 21.9 months). Most infections are present clinically as pneumonia, septicemia, men...

journal_title：Cancer investigation

authors： Rosner F,Zarrabi MH

更新日期：1983-01-01 00:00:00

abstract：:Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 i...

journal_title：Cancer investigation

authors： Tiscornia MM,González HS,Lorenzati MA,Zapata PD

更新日期：2015-03-01 00:00:00

abstract：BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from ...

journal_title：Cancer investigation

authors： Wirth MD,Burch JB,Hébert JR,Kowtal P,Mehrotra-Kapoor A,Steck SE,Hurley TG,Gupta PC,Pednekar MS,Youngstedt SD,Zhang H,Sarin R

更新日期：2014-08-01 00:00:00

abstract：:One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved loc...

journal_title：Cancer investigation

authors： De Bari B,Lestrade L,Pommier P,Maddalo M,Buglione M,Magrini SM,Carrie C

更新日期：2015-04-01 00:00:00

abstract：:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

journal_title：Cancer investigation

authors： Herbert PN,Friedland ML

更新日期：1986-01-01 00:00:00

abstract：:In conclusion, the prognosis for women with stage I borderline tumors is excellent. Surgery alone is the recommended treatment. For young patients, fertility-sparing surgery is optimal, with a small percentage eventually developing tumor in the contralateral ovary. For patients with advanced stage borderline tumors, 1...

journal_title：Cancer investigation

authors： Gershenson DM

更新日期：1999-01-01 00:00:00

abstract：:Placement of carmustine-impregnated wafers has become a common practice after surgical resection of malignant gliomas. Bevacizumab is used as a second-line agent for the treatment of malignant gliomas and is sometimes used in patients who have had recent wafer implantation. We describe two cases of fatal cerebrospinal...

journal_title：Cancer investigation

authors： Nagaiah G,Almubarak M,Khan M,Altaha R

更新日期：2010-12-01 00:00:00

abstract：:Serum C-reactive protein (CRP), a sensitive marker of systemic inflammation, has been reported to be associated with the risk of a number of cancers including breast cancer. However, the results are inconsistent. To investigate the association between serum CRP levels and early breast cancer, we conducted a hospital-b...

journal_title：Cancer investigation

authors： Hong T,Liu A,Cai D,Zhang Y,Hua D,Hang X,Wu X

更新日期：2013-05-01 00:00:00

abstract：:The present study examines the effect of tobacco smoking on the expression of cyclooxygenase (COX)-2 gene, COX enzymatic activity and prostaglandin (PG) synthesis in urothelial mucosal tissues from patients with bladder cancer and from normal individuals. The detection frequency of COX-2 mRNA was 2-fold higher in blad...

journal_title：Cancer investigation

authors： Badawi AF,Habib SL,Mohammed MA,Abadi AA,Michael MS

更新日期：2002-01-01 00:00:00

abstract：:ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...

journal_title：Cancer investigation

authors： Wang H,Yang Q,Fu Z,Zuo D,Hua Y,Cai Z

更新日期：2014-12-01 00:00:00

abstract：:Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibition by tyrphostin AG1024 in the presence or absence of doxorubicin in a...

journal_title：Cancer investigation

authors： Luk F,Yu Y,Walsh WR,Yang JL

更新日期：2011-10-01 00:00:00

abstract：:To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined the methylation status of 8 genes, including FLNC, EFS, ECRG4, RARB2, PITX2, GSTP1, PDLIM4, and KCNMA1 in 32 nonrecurrent, 32 recurrent primary prostate tumors, ...

journal_title：Cancer investigation

authors： Vanaja DK,Ehrich M,Van den Boom D,Cheville JC,Karnes RJ,Tindall DJ,Cantor CR,Young CY

更新日期：2009-06-01 00:00:00

abstract：:Lung cancer is the leading cause of cancer death worldwide and small cell lung cancer (SCLC) accounts for a significant proportion of all lung cancer cases. Even so, the underlying mechanism governing SCLC development remains poorly understood and SCLC related cancer death stands high despite decades of intensive inve...

journal_title：Cancer investigation

authors： Yang H,Luo J,Liu Z,Zhou R,Luo H

更新日期：2015-04-01 00:00:00

abstract：:Psychosocial adjustment in adolescent cancer survivors has been documented to be quite variable. Factors mediating adjustment need to be identified. The current study is an exploration of the impact that cancer diagnosis and treatment has on adolescent's self-perceptions and the role this has in mediating adjustment i...

journal_title：Cancer investigation

authors： Smith K,Ostroff J,Tan C,Lesko L

更新日期：1991-01-01 00:00:00