Abstract:
:Psychosocial adjustment in adolescent cancer survivors has been documented to be quite variable. Factors mediating adjustment need to be identified. The current study is an exploration of the impact that cancer diagnosis and treatment has on adolescent's self-perceptions and the role this has in mediating adjustment in this group. Fifty-eight adolescent survivors of hematologic malignancies were interviewed about alterations in self-perceptions related to their cancer experience and completed a cancer-specific social problem-solving task. Initial findings suggest that cancer universally alters the way adolescent survivors view themselves, but that the alteration can be both positive or negative depending on the meaning ascribed to it.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Smith K,Ostroff J,Tan C,Lesko Ldoi
10.3109/07357909109018956subject
Has Abstractpub_date
1991-01-01 00:00:00pages
581-8issue
5eissn
0735-7907issn
1532-4192journal_volume
9pub_type
杂志文章abstract::We analyzed the clinical utility of molecular classification based on anatomical and histological background. The study was conducted on 457 patients treated for gastric cancer with additional information about microsatellite instability status. We divided the patients in three groups of molecular classification based...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1292519
更新日期:2017-05-28 00:00:00
abstract::Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adu...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.654872
更新日期:2012-03-01 00:00:00
abstract::Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.732164
更新日期:2012-12-01 00:00:00
abstract::The structural dimensions of capillary tight junctions and the uptake of 99mTc pertechnetate in human gliomas were studied. Quantitative analysis revealed a correlation between the uptake of radionuclides and the length of endothelial tight junctions. It is suggested that brain scintigraphy might be used for the selec...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908609039831
更新日期:1986-01-01 00:00:00
abstract::N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309020257
更新日期:1993-01-01 00:00:00
abstract::8-Chloro-cyclic-adenosine-3',5'-monophosphate (8-Cl-cAMP), a site-selective synthetic cyclic adenosine 3',5'-monophosphate (cAMP) analog exhibits growth inhibition in a broad spectrum of human cancer lines. However, detailed studies on the effects exerted by cAMP analogs on cell-cycle kinetics have been lacking. We ha...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120005913
更新日期:2002-01-01 00:00:00
abstract::Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.802798
更新日期:2013-07-01 00:00:00
abstract::This study is to evaluate the association between IL-8 -251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 -251A/T polymorphism was not associ...
journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
doi:10.3109/07357907.2014.964410
更新日期:2014-12-01 00:00:00
abstract::This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.834925
更新日期:2013-10-01 00:00:00
abstract::Thirty patients with a diagnosis of metastatic adenocarcinoma of the lung were entered on a trial to evaluate the antitumor efficacy of 5-fluorouracil 370 mg/m2 daily for 5 days every four weeks in combination with folinic acid 200 mg/m2, 60 min prior to 5FU. All patients had a good performance status, bidimensionally...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909009012052
更新日期:1990-01-01 00:00:00
abstract::This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1625055
更新日期:2019-01-01 00:00:00
abstract::The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409021402
更新日期:1994-01-01 00:00:00
abstract::The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357908909039849
更新日期:1989-01-01 00:00:00
abstract::The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.1080/07357907.2017.1295461
更新日期:2017-05-28 00:00:00
abstract::Several studies have shown that sera from patients with Hodgkin's disease contain factors capable of inhibiting polymorphonuclear functions, among them chemotaxis. In the present study, we investigated whether these sera, which were able to inhibit PMN chemotaxis in the agarose test, were also able to affect the 3H-NE...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409024868
更新日期:1994-01-01 00:00:00
abstract::Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated wi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1852411
更新日期:2021-01-01 00:00:00
abstract::Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802672720
更新日期:2009-08-01 00:00:00
abstract::The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120025089
更新日期:2003-01-01 00:00:00
abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024890
更新日期:1995-01-01 00:00:00
abstract::Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701518487
更新日期:2007-10-01 00:00:00
abstract::The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657817
更新日期:2012-05-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600970490
更新日期:2007-02-01 00:00:00
abstract::We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309011669
更新日期:1993-01-01 00:00:00
abstract::Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600629575
更新日期:2006-04-01 00:00:00
abstract::We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903095623
更新日期:2010-07-01 00:00:00
abstract::Interstitial collagenase-1 degrades a variety of extracellular matrix components. A single guanine insertion polymorphism in the promoter has been found that influences on the transcription and expression level of the gene. It is suggested that this polymorphism may enhance susceptibility to some types of cancer. Ther...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900801953204
更新日期:2008-10-01 00:00:00
abstract::It is believed that telomerase is a terminal effector and its role is to maintain the length of telomeres. However, the main rate-limiting subunit of telomerase, human telomerase reverse transcriptase (hTERT), has been recently proved to have the ability to affect a variety of other genes such as p53 independently of ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900802491451
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120000360
更新日期:2002-01-01 00:00:00
abstract::Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600981398
更新日期:2006-11-01 00:00:00
abstract::Doxorubicin and paclitaxel are highly active agents in the treatment of advanced breast cancer. Although early trials of the combination reported high response rates, an unexpectedly high incidence of congestive heart failure observed on two of the early trials was cause for much concern. More recently, clinical trial...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-100000150
更新日期:2001-01-01 00:00:00