Abstract:
:Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d. from the first week to the completion of radiation with fluconazole 100 mg., q.d. for 14 days initiated during the fourth week. The remaining individuals were placed on the same dosages of the two drugs dispensed simultaneously after symptoms appeared. For both cohorts the combination of sucralfate and fluconazole was effective in diminishing oral discomfort and pain associated with radiation and chemotherapy. When medication was delivered from the first week of therapy, all patients could achieve the prescribed radiation dose without treatment interruption and be maintained on a regular diet. The combination of drugs was also effective in minimizing symptoms once they appeared.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Allison RR,Vongtama V,Vaughan J,Shin KHdoi
10.3109/07357909509024890subject
Has Abstractpub_date
1995-01-01 00:00:00pages
16-22issue
1eissn
0735-7907issn
1532-4192journal_volume
13pub_type
杂志文章abstract::Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...
journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2019-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
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abstract::Acute promyelocytic leukemia (APL) is characterized by specific t(15;17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct s...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.629378
更新日期:2012-01-01 00:00:00
abstract::Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600629575
更新日期:2006-04-01 00:00:00
abstract::Several studies have shown that sera from patients with Hodgkin's disease contain factors capable of inhibiting polymorphonuclear functions, among them chemotaxis. In the present study, we investigated whether these sera, which were able to inhibit PMN chemotaxis in the agarose test, were also able to affect the 3H-NE...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409024868
更新日期:1994-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120023770
更新日期:2003-01-01 00:00:00
abstract::Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2019.1662918
更新日期:2019-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1808898
更新日期:2020-09-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.802798
更新日期:2013-07-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.732164
更新日期:2012-12-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120001147
更新日期:2002-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-67147
更新日期:2005-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012191
更新日期:2000-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701637949
更新日期:2008-02-01 00:00:00
abstract:PURPOSE:Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532, an inhibitor of telomerase on chondrosarcoma cells in vitro. METHODS:Telomerase activity, telomere lengths, growth kinetics and chemosensitivity were analyzed in...
journal_title:Cancer investigation
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更新日期:2008-07-01 00:00:00
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357908709011740
更新日期:1987-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120022382
更新日期:2003-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.877480
更新日期:2014-03-01 00:00:00
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doi:10.1080/07357900701840212
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
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更新日期:1992-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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更新日期:1997-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2000-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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更新日期:2006-10-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:1996-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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更新日期:2003-06-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2021-01-06 00:00:00