Type 2 Diabetes Associated with Abnormal p53 Immunohistochemical Patterns in Colorectal Cancer.

Abstract:

:Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated with p53-AP in overall patients, patients with microsatellite instability (MSI) stable/MSI-low phenotype or distal colorectal location. Furthermore, p53-AP was positively associated with lymph node metastasis and high TNM stage. Metformin treatment was negatively associated with p53-AP in T2DM patients. The results suggested T2DM might influence carcinogenesis, progression and prognosis via inducing TP53 mutation and abnormal p53 expression in CRC.

journal_name

Cancer Invest

journal_title

Cancer investigation

authors

Yang Z,Ma J,Qi G,Zhang X

doi

10.1080/07357907.2020.1852411

subject

Has Abstract

pub_date

2021-01-01 00:00:00

pages

73-83

issue

1

eissn

0735-7907

issn

1532-4192

journal_volume

39

pub_type

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