IGF1R-targeted therapy and its enhancement of doxorubicin chemosensitivity in human osteosarcoma cell lines.

abstract：:Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...

journal_title：Cancer investigation

authors： Amirghofran Z,Bahmani M,Azadmehr A,Ashouri E,Javidnia K

更新日期：2007-10-01 00:00:00

abstract：:We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice....

journal_title：Cancer investigation

authors： Dai J,Wang H,Dong Y,Zhang Y,Wang J

更新日期：2013-02-01 00:00:00

abstract：:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...

journal_title：Cancer investigation

authors： Schattner EJ

更新日期：2002-01-01 00:00:00

abstract：:Because most cancer deaths result from disseminated disease, understanding the regulation of tumor invasion and metastasis is a central theme in tumor cell biology. Interactions between extracellular matrices (ECM) and cellular microenvironment play a crucial role in this process. We have tested selected amino acids a...

journal_title：Cancer investigation

authors： Singh RK,Rinehart CA,Kim JP,Tolleson-Rinehart S,Lawing LF,Kaufman DG,Siegal GP

更新日期：1996-01-01 00:00:00

abstract：:This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...

journal_title：Cancer investigation

authors： Hardy WD Jr

更新日期：1983-01-01 00:00:00

abstract：:IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infecti...

journal_title：Cancer investigation

authors： Mahanty S,Nutman TB

更新日期：1993-01-01 00:00:00

abstract：:The standard staging evaluation of prostate cancer includes digital rectal examination, measurement of serum tumor markers, radionuclide bone scan, and abdominal pelvic computed tomography (CT) or nuclear magnetic resonance imaging (MRI). We retrospectively reviewed 300 cases of newly diagnosed, untreated adenocarcino...

journal_title：Cancer investigation

authors： Huncharek M,Muscat J

更新日期：1995-01-01 00:00:00

abstract：:A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...

journal_title：Cancer investigation

authors： Golden L,Ahlgren JD,Kattah J,Smith JW,Sisk R,Deeb Z

更新日期：1989-01-01 00:00:00

abstract：:Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and...

journal_title：Cancer investigation

authors： Queiroz RM,Takiya CM,Guimarães LP,Rocha Gda G,Alviano DS,Blank AF,Alviano CS,Gattass CR

更新日期：2014-07-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent mitogen in various precursor tumor cells, including endometrial adenocarcinoma. It is proposed that ET-1 produced by endometrial adenocarcinoma may participate in the angiogenesis of this carcinoma in vivo. Endothelin converting enzyme-1 (ECE-1) is the key enzyme that synthesizes ET-1. ...

journal_title：Cancer investigation

authors： Arun B,Kilic G,Ashfaq R,Saboorian HM,Gokaslan T

更新日期：2001-01-01 00:00:00

abstract：:Enhanced proteolysis and altered tight junction (TJ) proteins associate with carcinoma invasion. We hypothesized that trypsin-2, a tumor-associated serine proteinase, induces tongue carcinoma invasion by activating pro-membrane type-1 matrix metalloproteinase (MT1-MMP) and disturbing the TJs. The effects of invasion w...

journal_title：Cancer investigation

authors： Vilen ST,Suojanen J,Salas F,Risteli J,Ylipalosaari M,Itkonen O,Koistinen H,Baumann M,Stenman UH,Sorsa T,Salo T,Nyberg P

更新日期：2012-10-01 00:00:00

abstract：:The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...

journal_title：Cancer investigation

authors： Rüschoff JH,Brandenburger T,Strehler EE,Filoteo AG,Heinmöller E,Aumüller G,Wilhelm B

更新日期：2012-05-01 00:00:00

abstract：:Metastasis is the overwhelming cause of mortality in patients with breast cancer and our understanding of its cellular and molecular determinants is limited. Among cellular determinants, disseminated (DTC) tumor cells undoubtedly are key players in the metastatic cascade. In the past, several models have been construc...

journal_title：Cancer investigation

authors： Braun S,Auer D,Marth C

更新日期：2009-07-01 00:00:00

abstract：:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...

journal_title：Cancer investigation

authors： Erfani N,Razmkhah M,Ghaderi A

更新日期：2010-10-01 00:00:00

abstract：:Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Hi...

journal_title：Cancer investigation

authors： Germanová A,Germanová A,Tesarová P,Jáchymová M,Zvára K,Zima T,Kalousová M

更新日期：2009-07-01 00:00:00

abstract：:The interleukin-2 (IL2) gene is assigned to human chromosome 4. A synthetic oligonucleotide representing bases 285 to 324 of the IL2 cDNA clone described by Taniguchi et al. [Nature (London) 302:305-310, 1983] was used as hybridization probe in Southern blots. Eco RI digests of DNA derived from 11 somatic mouse-human ...

journal_title：Cancer investigation

authors： Sykora KW,Kolitz J,Szabo P,Grzeschik KH,Moore MA,Mertelsmann R

更新日期：1984-01-01 00:00:00

abstract：:A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...

journal_title：Cancer investigation

authors： Singh AP,Shah PP,Ruwali M,Mathur N,Pant MC,Parmar D

更新日期：2009-10-01 00:00:00

abstract：:There is no known effective salvage chemotherapy for patients with refractory or relapsed urothelial tumors after methotrexate/cisplatin-based regimen. We report the results of a phase II trial with the FIFO regimen that includes from day 1 to 5: fluorouracil 350 mg/m2, folinic acid 20 mg/m2, and ifosfamide 1000 mg/m2...

journal_title：Cancer investigation

authors： Kattan J,Culine S,Theodore C,Droz JP

更新日期：1995-01-01 00:00:00

abstract：:The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...

journal_title：Cancer investigation

authors： Baker DG,Krochak RJ

更新日期：1989-01-01 00:00:00

abstract：:Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...

journal_title：Cancer investigation

authors： Xi J,Zeng ST,Guo L,Feng J

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:Patients with systemic malignancies have substantial quantities of tumor-specific DNA in their plasma which may serve as a potential biomarker for tumor burden. This approach has not been studied in gliomas. METHODS:Methylation specific polymerase chain reaction (MSP) was used to determine the methylation st...

journal_title：Cancer investigation

authors： Weaver KD,Grossman SA,Herman JG

更新日期：2006-02-01 00:00:00

abstract：:Transarterial radioembolization (TARE) is one of the therapeutic options for hepatocellular carcinoma (HCC). This study aimed to investigate the predictors and prognostic values of achieving curative treatments after TARE. Overall, 143 patients with intrahepatic HCC treated with TARE between 2011 and 2017 were recruit...

journal_title：Cancer investigation

authors： Kim Y,Lee HA,Lee JS,Jeon MY,Kim BK,Park JY,Kim DY,Ahn SH,Um SH,Seo YS,Kim SU

更新日期：2021-01-11 00:00:00

abstract：:The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...

journal_title：Cancer investigation

authors： Shang D,Yang P,Liu Y,Song J,Zhang F,Tian Y

更新日期：2011-06-01 00:00:00

abstract：:Requirements for the induction of anomalous killer (AK) cells to syngeneic MOPC 104E-KI81 plasmacytoma, and their pattern of reaction were investigated. The AK cells are Thy-1.2 positive and were induced by cocultivation of normal BALB/c spleen cells for 5 days in vitro with mitomycin C-treated MOPC 104E-KI81 cells in...

journal_title：Cancer investigation

authors： Hayashida I,Hiramoto RN,Shrestha K,Ghanta VK

更新日期：1989-01-01 00:00:00

abstract：:Cytosolic and nuclear progesterone receptor levels (RPC, RPN) were measured in normal and in pathological human endometria after single-dose progesterone injection 1-3 h before tissue collection (test subjects) and the results compared to those obtained in controls (no progesterone treatment). In test cases of late pr...

journal_title：Cancer investigation

authors： Gorodeski IG,Geier A,Lunenfeld B,Bahary CM

更新日期：1988-01-01 00:00:00

abstract：:The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...

journal_title：Cancer investigation

authors： Benner SE,Fetting JH,Brenner MH

更新日期：1994-01-01 00:00:00

abstract：:Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...

journal_title：Cancer investigation

authors： Chen YM,Vaughn CB

更新日期：1989-01-01 00:00:00

abstract：BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was underta...

journal_title：Cancer investigation

authors： Anderson SE,O'Reilly EM,Kelsen DP,Ilson DH

更新日期：2003-01-01 00:00:00

abstract：:N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...

journal_title：Cancer investigation

authors： Pergolizzi RG,Kreis W,Rottach C,Susin M,Broome JD

更新日期：1993-01-01 00:00:00