Trypsin-2 enhances carcinoma invasion by processing tight junctions and activating ProMT1-MMP.

abstract：:Transarterial radioembolization (TARE) is one of the therapeutic options for hepatocellular carcinoma (HCC). This study aimed to investigate the predictors and prognostic values of achieving curative treatments after TARE. Overall, 143 patients with intrahepatic HCC treated with TARE between 2011 and 2017 were recruit...

journal_title：Cancer investigation

authors： Kim Y,Lee HA,Lee JS,Jeon MY,Kim BK,Park JY,Kim DY,Ahn SH,Um SH,Seo YS,Kim SU

更新日期：2021-01-11 00:00:00

abstract：:This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...

journal_title：Cancer investigation

authors： Zhao X,Liu J,Peng M,Liu J,Chen F

更新日期：2013-10-01 00:00:00

abstract：:The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...

journal_title：Cancer investigation

authors： Baker DG,Krochak RJ

更新日期：1989-01-01 00:00:00

abstract：:A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...

journal_title：Cancer investigation

authors： Golden L,Ahlgren JD,Kattah J,Smith JW,Sisk R,Deeb Z

更新日期：1989-01-01 00:00:00

abstract：:Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...

journal_title：Cancer investigation

authors： Olsen RS,Dimberg J,Geffers R,Wågsäter D

更新日期：2019-01-01 00:00:00

abstract：:SNPs in CYP1A1, CYP2A1, CYP2B6, CYP2C, CYP2D6, CYP3A, GSTM1, GSTT1, GSTP1, SULT1A1, SULT1A2, UGT, and MTHFR are associated with breast cancer susceptibility; however, lack of such associations are also reported in some populations. The contradictory findings are explained on the basis of ethnic variation among populat...

journal_title：Cancer investigation

authors： Singh V,Parmar D,Singh MP

更新日期：2008-10-01 00:00:00

abstract：:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

journal_title：Cancer investigation

authors： Herbert PN,Friedland ML

更新日期：1986-01-01 00:00:00

abstract：:In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...

journal_title：Cancer investigation

authors： Chen J,Chen Y,Chen Z

更新日期：2013-01-01 00:00:00

abstract：:Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...

journal_title：Cancer investigation

authors： Chen YM,Vaughn CB

更新日期：1989-01-01 00:00:00

abstract：:IL-5 is primarily a T-cell-derived cytokine that has multiple regulatory functions on eosinophils and (in the mouse) on antibody-secreting B cells. A complex network of cytokines appear to control transcription of the gene for IL-5 and its production. Abnormally high levels of this cytokine are associated with infecti...

journal_title：Cancer investigation

authors： Mahanty S,Nutman TB

更新日期：1993-01-01 00:00:00

abstract：:Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...

journal_title：Cancer investigation

authors： Karimi P,Hematti S,Safari F,Tavassoli M

更新日期：2013-11-01 00:00:00

abstract：:One of the hallmarks of cancer is limitless proliferative capacity, which is tightly associated with the ability to maintain telomeres. Over the last decade, the telomere biology of pediatric cancers has begun to be elucidated. Most pediatric leukemias and embryonal solid tumors activate the enzyme telomerase, a speci...

journal_title：Cancer investigation

authors： Tabori U,Dome JS

更新日期：2007-04-01 00:00:00

abstract：:Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...

journal_title：Cancer investigation

authors： Bogush TA,Polezhaev BB,Mamichev IA,Bogush EA,Polotsky BE,Tjulandin SA,Ryabov AB

更新日期：2018-04-21 00:00:00

abstract：:A patient with cervical metastases leading to the diagnosis of a primary breast cancer is presented. To better define the frequency, symptoms, and characteristics of breast cancer metastasizing to the uterine cervix, all cases reported in the literature since 1950 are reviewed. This analysis reveals that in 21% of the...

journal_title：Cancer investigation

authors： Hepp HH,Hoos A,Leppien G,Wallwiener D

更新日期：1999-01-01 00:00:00

abstract：:The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21...

journal_title：Cancer investigation

authors： Sapse DS,Tong Y,Bertino JR,Sapse AM

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...

journal_title：Cancer investigation

authors： Anders C,Marcom PK,Peterson B,Gu L,Unruhe S,Welch R,Lyons P,Behera M,Copland S,Kimmick G,Shaw H,Snyder S,Antenos M,Woodruff T,Blackwell K

更新日期：2008-04-01 00:00:00

abstract：:Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...

journal_title：Cancer investigation

authors： Cho H,Lee YS,Kim J,Chung JY,Kim JH

更新日期：2013-11-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...

journal_title：Cancer investigation

authors： Cascinu S,Del Ferro E,Ligi M,Staccioli MP,Giordani P,Catalano V,Agostinelli R,Muretto P,Catalano G

更新日期：2001-01-01 00:00:00

abstract：:The role of stereotactic body radiation therapy (SBRT) in achieving durable local control and palliation of pain in pelvic lymph node oligometastatic disease is not well-studied. We performed a retrospective analysis of 30 patients with 43 pelvic lymph node oligometastases from various primary cancers all but one with...

journal_title：Cancer investigation

authors： Reshko LB,Richardson MK,Spencer K,Kersh CR

更新日期：2020-11-01 00:00:00

abstract：:Multifractionated dosing (MFD) schedules for chemotherapy administration such as weekly or twice weekly administration are intended to maximize dose intensity while minimizing toxicity, but the cumulative drug effect may result in neutropenia necessitating interruption of dose fractions and thereby compromising dose i...

journal_title：Cancer investigation

authors： Lokich J

更新日期：1999-01-01 00:00:00

abstract：:We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...

journal_title：Cancer investigation

authors： Wzietek I,Suwinski R,Nowara E,Bialas M,Bentzen S,Tukiendorf A

更新日期：2014-01-01 00:00:00

abstract：:Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...

journal_title：Cancer investigation

authors： Luwor R,Morokoff AP,Amiridis S,D'Abaco G,Paradiso L,Stylli SS,Nguyen HPT,Tarleton M,Young KA,O'Brien TJ,Robinson PJ,Chircop M,McCluskey A,Jones NC

更新日期：2019-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is a potent mitogen in various precursor tumor cells, including endometrial adenocarcinoma. It is proposed that ET-1 produced by endometrial adenocarcinoma may participate in the angiogenesis of this carcinoma in vivo. Endothelin converting enzyme-1 (ECE-1) is the key enzyme that synthesizes ET-1. ...

journal_title：Cancer investigation

authors： Arun B,Kilic G,Ashfaq R,Saboorian HM,Gokaslan T

更新日期：2001-01-01 00:00:00

abstract：:We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years ...

journal_title：Cancer investigation

authors： Ingrosso G,Carosi A,Ponti E,Murgia A,di Cristino D,Barbarino R,Benassi M,Di Murro L,Giudice E,Bove P,Santoni R

更新日期：2014-12-01 00:00:00

abstract：:We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to b...

journal_title：Cancer investigation

authors： Gunduz E,Gunduz M,Ali MA,Beder L,Tamamura R,Katase N,Tominaga S,Yamanaka N,Shimizu K,Nagatsuka H

更新日期：2009-07-01 00:00:00

abstract：:Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...

journal_title：Cancer investigation

authors： Leonard JP,Siegel JA,Goldsmith SJ

更新日期：2003-04-01 00:00:00

abstract：:Placement of carmustine-impregnated wafers has become a common practice after surgical resection of malignant gliomas. Bevacizumab is used as a second-line agent for the treatment of malignant gliomas and is sometimes used in patients who have had recent wafer implantation. We describe two cases of fatal cerebrospinal...

journal_title：Cancer investigation

authors： Nagaiah G,Almubarak M,Khan M,Altaha R

更新日期：2010-12-01 00:00:00

abstract：:Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...

journal_title：Cancer investigation

authors： Allison RR,Vongtama V,Vaughan J,Shin KH

更新日期：1995-01-01 00:00:00

abstract：:Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...

journal_title：Cancer investigation

authors： Yoon L,Clarke Hillyer G,Chen L,Hu JC,Neugut AI,Hershman DL,Wright JD

更新日期：2016-09-13 00:00:00

abstract：:A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...

journal_title：Cancer investigation

authors： Singh AP,Shah PP,Ruwali M,Mathur N,Pant MC,Parmar D

更新日期：2009-10-01 00:00:00