Abstract:
:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and levels of the major HDL-apoprotein, apoA-I, rose from 60 to 138 mg/dl. The proportion of unesterified serum cholesterol fell from 60-80% to 27-30%. These observations suggest a relatively specific effect of the hepatic lymphoma on synthesis or release of lecithin:cholesterol acyltransferase.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Herbert PN,Friedland MLdoi
10.3109/07357908609017510subject
Has Abstractpub_date
1986-01-01 00:00:00pages
301-3issue
4eissn
0735-7907issn
1532-4192journal_volume
4pub_type
杂志文章abstract::Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100000069
更新日期:2001-01-01 00:00:00
abstract::This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.550663
更新日期:2011-03-01 00:00:00
abstract::We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.861470
更新日期:2014-01-01 00:00:00
abstract::CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802392675
更新日期:2009-03-01 00:00:00
abstract::Hepatitis B virus X protein (HBx) promotes hepatocellular carcinoma (HCC) invasion and metastasis by a poorly understood mechanism. This study investigated the role of NF-kappa B in HBx-mediated upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). In a stably expressing HBx c...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903405959
更新日期:2010-06-01 00:00:00
abstract::Precise quantification of oral complications in cancer patients receiving bone marrow and stem cell transplantation is essential when testing new treatment strategies for mucositis. Using 133 adult transplant patients, the authors evaluated the 20 item oral mucositis index (OMI), adapted from the 34 item OMI, to facil...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120005902
更新日期:2002-01-01 00:00:00
abstract::Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1653465
更新日期:2019-01-01 00:00:00
abstract::Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509031914
更新日期:1995-01-01 00:00:00
abstract::PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701506573
更新日期:2007-12-01 00:00:00
abstract::Fibronectin (Fn) synergizes with macrophages (M phi) in inducing cytostasis and cytotoxicity of neoplastic cells in culture. Since heparin enhances Fn's opsonic activity in many systems, we investigated its effect on Fn-macrophage synergy in cytostasis. MCG-T14 (a spontaneous mouse mammary adenocarcinoma) cells (4 X 1...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908409040310
更新日期:1984-01-01 00:00:00
abstract::Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2016.1242010
更新日期:2016-11-25 00:00:00
abstract::Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120016404
更新日期:2003-01-01 00:00:00
abstract::The aim of our study was to investigate the role of nerve growth factor (NGF) on the expression of the p73 protein in human ependymoblastoma (EP) and medulloblastoma (MB) cells. It was found that NGF exposure on MB cells blocks proliferation, as well as on EP cells and induces overexpression of p73. NGF reduces the nu...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701205689
更新日期:2007-03-01 00:00:00
abstract::The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.568566
更新日期:2011-06-01 00:00:00
abstract::Fulvestrant (Faslodex) is a new type of estrogen receptor (ER) antagonist that binds, blocks, and degrades the ER, leading to reduced expression of the progesterone receptor (PgR). Unlike the selective ER modulator tamoxifen, fulvestrant is devoid of any known agonist activity. Fulvestrant has a steroidal structure th...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-50480
更新日期:2005-01-01 00:00:00
abstract::Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::erbB-2 protein is believed to be a cell membrane receptor for the recently identified ligand gp30. When overexpressed, erbB-2 is an indicator of poor prognosis in adenocarcinomas of breast, stomach, lung, and endometrium. Even more important, clinical data suggest that erbB-2 overexpression may be an indicator of poor...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909209024819
更新日期:1992-01-01 00:00:00
abstract::Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cell lymphoma tumor progression model. We compared these features and th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012202
更新日期:2000-01-01 00:00:00
abstract::Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors), cholesterol-lowering agents widely prescribed for cardiovascular health, have been shown to exert several pleiotropic effects. Although some studies reported that statins have no effects on malignancies of any kind, results of several epidemiologic ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900802491444
更新日期:2009-05-01 00:00:00
abstract::Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600894773
更新日期:2006-10-01 00:00:00
abstract::A randomized trial was conducted comparing ketoconazole and nystatin in the prevention of oral candidiasis and appearance of invasive fungal infections in 51 neutropenic leukemic patients undergoing induction chemotherapy. Ketoconazole was administered in a 200 mg dose twice daily. Nystatin oral suspension was given i...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-01-01 00:00:00
abstract:INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.535057
更新日期:2011-01-01 00:00:00
abstract::Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802672720
更新日期:2009-08-01 00:00:00
abstract::The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357908909039849
更新日期:1989-01-01 00:00:00
abstract::Expression of epidermal growth factor and its transmembrane receptor (EGFR) stimulates tumor growth. Matuzumab is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth, and provides a clinical benefit for some patients. The plasma half-life (6-10 days) an...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701511847
更新日期:2008-02-01 00:00:00
abstract::Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inherita...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909709047596
更新日期:1997-01-01 00:00:00
abstract::The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409021402
更新日期:1994-01-01 00:00:00
abstract::Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357900009031826
更新日期:2000-01-01 00:00:00
abstract::The immunotherapeutic effects of interleukin-1 alpha (IL-1 alpha) encapsulated within 1-5 microns-diameter poly (D, L-lactide) microspheres and delivered intratumorally into fibrosarcoma-bearing mice were investigated. Such microspheres are avidly taken up by macrophages, and directing IL-1 alpha into these cells may ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120023770
更新日期:2003-01-01 00:00:00
abstract::Neural stem cells (NSC) are capable of differentiating toward neuronal, astrocytic, oligodendrocytic and glial lineages, depending on their spatial location within the central nervous system (CNS). Although, a lot of knowledge has been gained in the understanding of differentiation-specific signaling in hematopoietic ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-200039679
更新日期:2004-01-01 00:00:00