Abstract:
INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by immunohistochemistry of prostate tissue microarrays. RESULTS:(Pro)thrombin mRNA expression was detected in cancer tissue and localized to prostatic epithelium and stroma by ISH. Thrombin protein was detected in stroma of benign and malignant epithelium (p <.05). CONCLUSIONS:Prostate tissue is a rich reservoir of thrombin. This may have potential for developing antithrombin-based cancer therapy.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Kohli M,Williams K,Yao JL,Dennis RA,Huang J,Reeder J,Ricke WAdoi
10.3109/07357907.2010.535057subject
Has Abstractpub_date
2011-01-01 00:00:00pages
62-7issue
1eissn
0735-7907issn
1532-4192journal_volume
29pub_type
杂志文章abstract::The results of a prospective trial with a specifically devised chemotherapy regimen in elderly patients with unfavorable non-Hodgkin's lymphoma (NHL) are reported. Between April 1983 and April 1986, 37 consecutive patients 70 years old or more (median age 80) received etoposide and prednimustine (E + P) 100 mg/m2 p.o....
journal_title:Cancer investigation
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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journal_title:Cancer investigation
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pub_type: 临床试验,杂志文章
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
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pub_type: 临床试验,杂志文章,多中心研究
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journal_title:Cancer investigation
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更新日期:1993-01-01 00:00:00
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2012-03-01 00:00:00