Abstract:
:The results of a prospective trial with a specifically devised chemotherapy regimen in elderly patients with unfavorable non-Hodgkin's lymphoma (NHL) are reported. Between April 1983 and April 1986, 37 consecutive patients 70 years old or more (median age 80) received etoposide and prednimustine (E + P) 100 mg/m2 p.o. for 5 days every 21 days. Thirteen patients were previously treated. Objective response rate in the 35 evaluable patients is 66% with 46% complete response. The objective response rate in the 22 previously untreated patients is nearly 70% with 50% complete response. Median survival is 14 months. The overall toxicity was reasonably acceptable. There were 5% (2 patients) treatment-related deaths, but in an unselected elderly population. We experienced the usefulness of a properly oriented clinical approach to elderly patients with NHL. We suggest that a combination regimen E + P, suitable for oral administration, may be safely employed in elderly patients with unfavorable NHL.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Zagonel V,Tirelli U,Carbone A,Errante D,Morassot S,Sorio R,Monfardini Sdoi
10.3109/07357909009018923subject
Has Abstractpub_date
1990-01-01 00:00:00pages
577-82issue
6eissn
0735-7907issn
1532-4192journal_volume
8pub_type
杂志文章abstract::Doxorubicin and paclitaxel are highly active agents in the treatment of advanced breast cancer. Although early trials of the combination reported high response rates, an unexpectedly high incidence of congestive heart failure observed on two of the early trials was cause for much concern. More recently, clinical trial...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-100000150
更新日期:2001-01-01 00:00:00
abstract::SNPs in CYP1A1, CYP2A1, CYP2B6, CYP2C, CYP2D6, CYP3A, GSTM1, GSTT1, GSTP1, SULT1A1, SULT1A2, UGT, and MTHFR are associated with breast cancer susceptibility; however, lack of such associations are also reported in some populations. The contradictory findings are explained on the basis of ethnic variation among populat...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900801953196
更新日期:2008-10-01 00:00:00
abstract::We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.762781
更新日期:2013-02-01 00:00:00
abstract::ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2014.964409
更新日期:2014-12-01 00:00:00
abstract::We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802570759
更新日期:2009-02-01 00:00:00
abstract::Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m(2) every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.3109/07357900902918460
更新日期:2010-03-01 00:00:00
abstract::ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003631007
更新日期:2010-07-01 00:00:00
abstract::In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor ti...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.820318
更新日期:2013-08-01 00:00:00
abstract::Here 145 reported post-splenectomy infections in 115 patients with Hodgkin's disease are reviewed. Such infections can occur at any age (median age 19.8 years) and the interval from splenectomy to the infection is quite variable (median 21.9 months). Most infections are present clinically as pneumonia, septicemia, men...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908309040933
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was underta...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120022360
更新日期:2003-01-01 00:00:00
abstract::Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003630934
更新日期:2010-10-01 00:00:00
abstract::Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.697232
更新日期:2012-08-01 00:00:00
abstract::In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.743557
更新日期:2013-01-01 00:00:00
abstract::The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120025089
更新日期:2003-01-01 00:00:00
abstract::Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1653465
更新日期:2019-01-01 00:00:00
abstract::The overexpression of HER-2/neu and p53 has been associated with poor outcome in many neoplasms. Their role in patients with osteosarcoma is unclear. We studied the expression of HER-2/neu and p53 in 22 osteosarcoma samples (from 20 patients--2 had locally recurrent disease) biopsied at the University of Medicine and ...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120027577
更新日期:2004-01-01 00:00:00
abstract::Soft tissue sarcomas are generally resistant to most chemotherapeutic agents, and individuals with advanced disease have a poor prognosis. We evaluated amonafide, a new drug that has significant activity against several tumor cell lines, to determine its activity against sarcomas. Amonafide was administered to 18 pati...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357909409038230
更新日期:1994-01-01 00:00:00
abstract::Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.721039
更新日期:2012-10-01 00:00:00
abstract::High expression of vascular endothelial growth factor (VEGF) in patients with hepatocellular carcinoma (HCC) is associated with poor prognosis. Here, we investigated the antitumor activity of lenvatinib, a multiple receptor tyrosine kinase inhibitor, in VEGF-overexpressing HCC models. In human umbilical vein endotheli...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1601209
更新日期:2019-01-01 00:00:00
abstract::Macrophages in malignant pleural effusions (MPEs) demonstrate a promalignant phenotype. They release mediators, which are a source of inflammation within the pleura. We established in vitro model proving that pleural macrophages isolated from effusions affect cancer cells in their pro- or anti-apoptotic activity via h...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1477158
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Although treatment-related lymphopenia (TRL) is common in many cancers no data exists in rectal cancer. METHODS:Serial lymphocyte counts were analyzed retrospectively in patients with newly diagnosed rectal cancer, serial blood counts, and complete records at Johns Hopkins Hospital. RESULTS:Fifty-seven pat...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1499028
更新日期:2018-01-01 00:00:00
abstract::Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701637824
更新日期:2008-03-01 00:00:00
abstract::We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309011669
更新日期:1993-01-01 00:00:00
abstract::Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2020.1802474
更新日期:2020-09-01 00:00:00
abstract::Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120027587
更新日期:2004-01-01 00:00:00
abstract::Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600814847
更新日期:2006-08-01 00:00:00
abstract::The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657815
更新日期:2012-05-01 00:00:00
abstract::Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509011686
更新日期:1995-01-01 00:00:00
abstract::Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120002951
更新日期:2002-01-01 00:00:00