Antitumor and Antiangiogenic Activities of Lenvatinib in Mouse Xenograft Models of Vascular Endothelial Growth Factor-Induced Hypervascular Human Hepatocellular Carcinoma.

abstract：:Primary squamous cell carcinoma of the breast is a rare clinical entity. We diagnosed a patient who presented with a pure squamous cell cancer of the breast 12 years after local radiation for a primary adenocarcinoma of breast. Previously reported cancers related to radiation of the breast have been squamous cell of s...

journal_title：Cancer investigation

authors： Singh H,Williams SP,Kinsella V,Lynch GR

更新日期：2000-01-01 00:00:00

abstract：:ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...

journal_title：Cancer investigation

authors： Wang H,Yang Q,Fu Z,Zuo D,Hua Y,Cai Z

更新日期：2014-12-01 00:00:00

abstract：:The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC...

journal_title：Cancer investigation

authors： Szondy K,Rusai K,Szabó AJ,Nagy A,Gal K,Fekete A,Kovats Z,Losonczy G,Lukacsovits J,Müller V

更新日期：2012-05-01 00:00:00

abstract：:The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was c...

journal_title：Cancer investigation

authors： Chaudhry P,Srinivasan R,Patel FD

更新日期：2009-10-01 00:00:00

abstract：:Based on cost-effective ratio, there has not yet been imaging methods suitable for breast cancer screening in young women. The aim of this study was to evaluate the sensitivity and specificity of the combination of electrical impedance scanning (EIS) and ultrasound in identifying breast cancer for young women, to calc...

journal_title：Cancer investigation

authors： Wang T,Wang K,Yao Q,Chen JH,Ling R,Zhang JL,Dong XZ,Fu F,Dou KF,Wang L

更新日期：2010-03-01 00:00:00

abstract：:Non-invasive pharmacological management of patients with cancer related pain has resulted in pain control in 90-95% of the patients. Thus, 5-10% of patients still experience inadequate pain control despite aggressive combined pharmacological therapy. Moreover, patients may not tolerate an aggressive program of titrati...

journal_title：Cancer investigation

authors： de Leon-Casasola OA

更新日期：2004-01-01 00:00:00

abstract：:Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...

journal_title：Cancer investigation

authors： Bauer TM,Berlin JD

更新日期：2008-03-01 00:00:00

abstract：:Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inherita...

journal_title：Cancer investigation

authors： Foroud T

更新日期：1997-01-01 00:00:00

abstract：:The host immune response can impact cancer growth, prognosis, and response to therapy. In colorectal cancer, the presence of cells involved with T-cell-mediated adaptive immunity predicts survival better than the current staging method. We used the expression of genes recently associated with host immune responses (T(...

journal_title：Cancer investigation

authors： Hsu DS,Kim MK,Balakumaran BS,Acharya CR,Anders CK,Clay T,Lyerly HK,Drake CG,Morse MA,Febbo PG

更新日期：2010-08-01 00:00:00

abstract：:A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA m...

journal_title：Cancer investigation

authors： Copeland WC,Wachsman JT,Johnson FM,Penta JS

更新日期：2002-01-01 00:00:00

abstract：:In a sample of 633 US adult breast cancer survivors, we examined health-related worry as a function vulnerability as influenced by communication, trust, and planning with their cancer care team during the COVID-19 pandemic. We found significant positive correlations between communication and trust, communication and p...

journal_title：Cancer investigation

authors： Papautsky EL,Hamlish T

更新日期：2021-01-01 00:00:00

abstract：:Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...

journal_title：Cancer investigation

authors： Zakaria MA,Rajab NF,Chua EW,Selvarajah GT,Masre SF

更新日期：2020-09-01 00:00:00

abstract：:This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...

journal_title：Cancer investigation

authors： Zhao X,Liu J,Peng M,Liu J,Chen F

更新日期：2013-10-01 00:00:00

abstract：:In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...

journal_title：Cancer investigation

authors： Chen J,Chen Y,Chen Z

更新日期：2013-01-01 00:00:00

abstract：:Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adu...

journal_title：Cancer investigation

authors： Bielanska J,Hernández-Losa J,Moline T,Somoza R,Ramón y Cajal S,Condom E,Ferreres JC,Felipe A

更新日期：2012-03-01 00:00:00

abstract：:Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...

journal_title：Cancer investigation

authors： Jasin M

更新日期：2000-01-01 00:00:00

abstract：:Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...

journal_title：Cancer investigation

authors： Habif DV,Ozzello L,De Rosa CM,Cantell K,Lattes R

更新日期：1995-01-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：OBJECTIVES:To evaluate the efficacy and toxicity of the combination of vinorelbine and interleukin (IL)-2 in patients with metastatic melanoma as second-line chemotherapy. PATIENTS AND METHODS:Twenty-two patients with histologically confirmed stage IV melanoma previously treated with temozolomide-based chemotherapy--o...

journal_title：Cancer investigation

authors： Gogas H,Bafaloukos D,Aravantinos G,Fountzilas G,Tsoutsos D,Panagiotou P,Frangia K,Kalofonos HP,Briasoulis E,Castana O,Polyzos A,Pectasides D,Ioannovich J,Hellenic Cooperative Oncology Group.

更新日期：2004-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...

journal_title：Cancer investigation

authors： Cascinu S,Del Ferro E,Ligi M,Staccioli MP,Giordani P,Catalano V,Agostinelli R,Muretto P,Catalano G

更新日期：2001-01-01 00:00:00

abstract：:Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...

journal_title：Cancer investigation

authors： Agah S,Akbari A,Talebi A,Masoudi M,Sarveazad A,Mirzaei A,Nazmi F

更新日期：2017-11-26 00:00:00

abstract：:Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...

journal_title：Cancer investigation

authors： Cadieux PA,Mikolajczak SA,Reeves J,Strathdee C,Reid G,Panchal CJ,Clarke MW

更新日期：2006-04-01 00:00:00

abstract：:To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...

journal_title：Cancer investigation

authors： Xiaojiang T,Jinsong Z,Jiansheng W,Chengen P,Guangxiao Y,Quanying W

更新日期：2010-06-01 00:00:00

abstract：:Thirty patients with a diagnosis of metastatic adenocarcinoma of the lung were entered on a trial to evaluate the antitumor efficacy of 5-fluorouracil 370 mg/m2 daily for 5 days every four weeks in combination with folinic acid 200 mg/m2, 60 min prior to 5FU. All patients had a good performance status, bidimensionally...

journal_title：Cancer investigation

authors： Evans WK,Wierzbicki R,Shepherd FA,Rusthoven J,Stewart DJ,Aitken SE,Maroun JA,Ezzat A

更新日期：1990-01-01 00:00:00

abstract：:Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...

journal_title：Cancer investigation

authors： Olsen RS,Dimberg J,Geffers R,Wågsäter D

更新日期：2019-01-01 00:00:00

abstract：:Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D...

journal_title：Cancer investigation

authors： Picotto G,Liaudat AC,Bohl L,Tolosa de Talamoni N

更新日期：2012-10-01 00:00:00

abstract：:The present study examines the effect of tobacco smoking on the expression of cyclooxygenase (COX)-2 gene, COX enzymatic activity and prostaglandin (PG) synthesis in urothelial mucosal tissues from patients with bladder cancer and from normal individuals. The detection frequency of COX-2 mRNA was 2-fold higher in blad...

journal_title：Cancer investigation

authors： Badawi AF,Habib SL,Mohammed MA,Abadi AA,Michael MS

更新日期：2002-01-01 00:00:00

abstract：:The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...

journal_title：Cancer investigation

authors： Shang D,Yang P,Liu Y,Song J,Zhang F,Tian Y

更新日期：2011-06-01 00:00:00

abstract：:The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for ...

journal_title：Cancer investigation

authors： Retsky MW,Swartzendruber DE,Bame PD,Wardwell RH

更新日期：1994-01-01 00:00:00

abstract：:Between March 1986 and December 1987, two groups of consecutive patients with advanced breast cancer underwent epidoxorubicin (Epidx) monochemotherapy. Twenty-three patients (group A) received Epidx at a dose of 60 mg/m2 and 27 (group B) at a dose of 120 mg/m2 (i.v. every 3 weeks). No patient had undergone anthracycli...

journal_title：Cancer investigation

authors： Neri B,Pacini P,Algeri R,Lottini G,Rinaldini M,Tucci E,Pusterla R

更新日期：1993-01-01 00:00:00