Abstract:
:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first category is defined by malignant cells that are resistant to apoptosis due to expression of anti-apoptotic factors such as bcl-2 and cellular inhibitors of apoptosis (IAPs). These tumors would include CLL and follicular lymphomas, as well as some malignancies in which the tumor cells are infected by viruses that co-opt cell survival pathways, such as human T-cell leukemia/lymphoma virus (HTLV)-1. The second category, in which the malignant cells are apoptosis-prone, would include tumors arising in the context of impaired cytotoxic T-cell function. These neoplasms would include some human immunodeficiency virus (HIV)-related lymphomas such as Burkitt's lymphoma, and post-transplantation lymphomas. The third category would include neoplasms of intermediate sensitivity to apoptosis, some of which are associated with infection such as mucosa-associated lymphoid tissue (MALT) lymphomas of the stomach. Although this classification is tentative, it should evolve in parallel with our understanding of pathogenic mechanisms in lymphoid neoplasia, and provides a novel framework with which to consider the appropriateness of specific therapeutic strategies. Distinctions among lymphocytic tumors in terms of the likelihood of response to therapies such as antisense to bcl-2 related proteins, inhibitors of NF-kappa B activity, and new approaches aimed at bolstering the host's immune response, would cross standard classifications based on the T or B-cell origin of the tumor cells.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Schattner EJdoi
10.1081/cnv-120002951subject
Has Abstractpub_date
2002-01-01 00:00:00pages
737-48issue
5-6eissn
0735-7907issn
1532-4192journal_volume
20pub_type
杂志文章,评审abstract::Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1653465
更新日期:2019-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657817
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701781812
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909209024815
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100107738
更新日期:2001-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/07357900903095755
更新日期:2010-08-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039861
更新日期:1989-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309020257
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509024907
更新日期:1995-01-01 00:00:00
abstract::As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-58819
更新日期:2005-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1841220
更新日期:2021-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.820318
更新日期:2013-08-01 00:00:00
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120027577
更新日期:2004-01-01 00:00:00
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pub_type: 杂志文章
doi:10.3109/07357909409021402
更新日期:1994-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012202
更新日期:2000-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2014.964409
更新日期:2014-12-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.1001898
更新日期:2015-04-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1080/07357900802491444
更新日期:2009-05-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.626478
更新日期:2011-12-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909209024813
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:1984-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
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更新日期:1991-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909809032890
更新日期:1998-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
doi:10.1080/07357907.2020.1714053
更新日期:2020-03-01 00:00:00