Abstract：
BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was undertaken. METHODS:Both adenocarcinoma and squamous cell histology were included. Paclitaxel was administered at 140 mg/m2 over 96 hours every 21 days. Patients who had metastatic disease to the liver and transaminases greater than two times normal value received 120 mg/m2. Response to treatment was evaluated after the first two cycles and subsequently every third cycle. RESULTS:Ten men and four women were entered. All were eligible for response and had stage IV disease. Thirteen patients were previously treated. All 13 received prior short-duration paclitaxel-containing chemotherapy regimens. Eleven patients had adenocarcinoma and three squamous cell cancer. Patients completed a mean of two cycles (range one to eight) prior to disease progression. No major responses were observed. Toxicity was minimal and included grade 3/4 neutropenia in 14% of patients. One patient with adenocarcinoma demonstrated stable disease for 28 weeks. CONCLUSION:No major activity was observed in a population of previously treated patients. Ninety-six-hour paclitaxel in metastatic esophageal cancer is generally well tolerated with minimal toxicity; however, it is ineffective in previously treated patients. Further evaluation of this schedule of paclitaxel in combination with concurrent radiotherapy, where its radiosensitizing potential may be useful, is ongoing in locally advanced esophageal cancer.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Anderson SE,O'Reilly EM,Kelsen DP,Ilson DHdoi
10.1081/cnv-120022360subject
Has Abstractpub_date
2003-01-01 00:00:00pages
512-6issue
4eissn
0735-7907issn
1532-4192journal_volume
21pub_type
临床试验,杂志文章abstract：:The role of stereotactic body radiation therapy (SBRT) in achieving durable local control and palliation of pain in pelvic lymph node oligometastatic disease is not well-studied. We performed a retrospective analysis of 30 patients with 43 pelvic lymph node oligometastases from various primary cancers all but one with...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357907.2020.1801713
更新日期：2020-11-01 00:00:00
abstract：:Lung cancer is the leading cause of cancer death worldwide and small cell lung cancer (SCLC) accounts for a significant proportion of all lung cancer cases. Even so, the underlying mechanism governing SCLC development remains poorly understood and SCLC related cancer death stands high despite decades of intensive inve...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2015.1006329
更新日期：2015-04-01 00:00:00
abstract：:Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357908309063292
更新日期：1983-01-01 00:00:00
abstract：:Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909709039724
更新日期：1997-01-01 00:00:00
abstract：:Melanoma is an immunoresponsive malignancy. Interleukin-10 (IL-10) is a potent regulator of immunosuppression. The purpose of this research was to define the relationship of serum IL-10 to survival in patients with metastatic melanoma. Forty-one melanoma patients and 50 normal volunteers were analyzed. The median IL-1...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1081/cnv-100102550
更新日期：2001-01-01 00:00:00
abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357907.2019.1630633
更新日期：2019-01-01 00:00:00
abstract：:Mice bearing LP07 lung adenocarcinoma present some characteristics similar to those shown in patients with several malignant diseases. LP07 tumor bearers develop paraneoplastic syndromes such as cachexia, leukocytosis, and hypercalcemia, partly due to a systemic inflammatory response. We analyzed some of the mechanism...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900500524322
更新日期：2006-03-01 00:00:00
abstract：:Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357908909039842
更新日期：1989-01-01 00:00:00
abstract：:Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.1080/07357900601130763
更新日期：2007-02-01 00:00:00
abstract：:It is believed that telomerase is a terminal effector and its role is to maintain the length of telomeres. However, the main rate-limiting subunit of telomerase, human telomerase reverse transcriptase (hTERT), has been recently proved to have the ability to affect a variety of other genes such as p53 independently of ...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357900802491451
更新日期：2009-12-01 00:00:00
abstract：:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.1081/cnv-120002951
更新日期：2002-01-01 00:00:00
abstract：:While cancer remains an important public health concern, novel and enhanced treatment modalities have increased the length of survival of individuals diagnosed with the disease. The treatment of most cancers requires the use of chemotherapeutic agents to affect cure, maintain control of the disease, or provide palliat...
journal_title：Cancer investigation
pub_type： 杂志文章,评审
doi：10.1081/cnv-120018236
更新日期：2003-06-01 00:00:00
abstract：:The aim of the current study was to determine the signaling differences between gamma- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or gamma-radiation. Proton beam was found to be more cytotoxic than gamma-radiation. Proton beam-irradiated cells showed phosphorylat...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357901003630991
更新日期：2010-07-01 00:00:00
abstract：:Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cell lymphoma tumor progression model. We compared these features and th...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357900009012202
更新日期：2000-01-01 00:00:00
abstract：:Although PKCs are assumed to be the main targets of phorbol esters (PMA), additional PMA effectors, such as chimaerins (a family of RacGTPase activating proteins) and RasGRP (exchange factor for Ras/Rap1), can counteract or strengthen the PKC pathways. In this study, we evaluated the proliferative behavior of PMA-trea...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900701637949
更新日期：2008-02-01 00:00:00
abstract：:Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...
journal_title：Cancer investigation
pub_type： 临床试验,杂志文章
doi：10.3109/07357909509011686
更新日期：1995-01-01 00:00:00
abstract：:Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909509024890
更新日期：1995-01-01 00:00:00
abstract：:Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated wi...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357907.2020.1852411
更新日期：2021-01-01 00:00:00
abstract：:The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909409021402
更新日期：1994-01-01 00:00:00
abstract：:The transforming growth factor beta 1 (TGF-beta1) is a multifunctional cytokine with several regulatory activities in tumor cells affecting growth, differentiation, and function. Alterations in gene expression, secretion, and regulation of TGF-beta1 may lead to a favorable environment for tumor development by angiogen...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900701600921
更新日期：2007-12-01 00:00:00
abstract：:One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved loc...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2014.1001898
更新日期：2015-04-01 00:00:00
abstract：:A dosimetric comparison was made of Helical Tomotherapy (HT) and Rapid'Arc(®) (RA) in 115 patients with head and neck carcinoma included in a prospective and multicentric study. HT and RA provided highly conformal plans that easily complied with dose volume constraints for organs at risk. HT reduced high doses to the ...
journal_title：Cancer investigation
pub_type： 杂志文章,多中心研究
doi：10.3109/07357907.2014.889705
更新日期：2014-06-01 00:00:00
abstract：:Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inherita...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909709047596
更新日期：1997-01-01 00:00:00
abstract：:Enhanced proteolysis and altered tight junction (TJ) proteins associate with carcinoma invasion. We hypothesized that trypsin-2, a tumor-associated serine proteinase, induces tongue carcinoma invasion by activating pro-membrane type-1 matrix metalloproteinase (MT1-MMP) and disturbing the TJs. The effects of invasion w...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2012.716467
更新日期：2012-10-01 00:00:00
abstract：:Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were f...
journal_title：Cancer investigation
pub_type： 杂志文章,meta分析
doi：10.1080/07357907.2020.1714053
更新日期：2020-03-01 00:00:00
abstract：:Here 145 reported post-splenectomy infections in 115 patients with Hodgkin's disease are reviewed. Such infections can occur at any age (median age 19.8 years) and the interval from splenectomy to the infection is quite variable (median 21.9 months). Most infections are present clinically as pneumonia, septicemia, men...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357908309040933
更新日期：1983-01-01 00:00:00
abstract：:Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357907.2013.849722
更新日期：2013-11-01 00:00:00
abstract：:Cisplatin (CDDP) was administered to a 49-year-old dialysis female patient with advanced uterine cervical cancer. Analysis of the pharmacokinetics of CDDP in the patient with renal failure and at hemodialysis were compared with that of patients without renal impairment. CDDP at 30 mg was administered by drip infusion....
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909109039874
更新日期：1991-01-01 00:00:00
abstract：:The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for ...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.3109/07357909409023040
更新日期：1994-01-01 00:00:00
abstract：:To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...
journal_title：Cancer investigation
pub_type： 杂志文章
doi：10.1080/07357900802527221
更新日期：2009-05-01 00:00:00
