Chemotherapy-induced peripheral neuropathy.

abstract：:Hepatitis B virus X protein (HBx) promotes hepatocellular carcinoma (HCC) invasion and metastasis by a poorly understood mechanism. This study investigated the role of NF-kappa B in HBx-mediated upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). In a stably expressing HBx c...

journal_title：Cancer investigation

authors： Liu LP,Liang HF,Chen XP,Zhang WG,Yang SL,Xu T,Ren L

更新日期：2010-06-01 00:00:00

abstract：:Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b i...

journal_title：Cancer investigation

authors： Liu W,Dong Z,Liang J,Guo X,Guo Y,Shen S,Kuang G,Guo W

更新日期：2016-11-25 00:00:00

abstract：:Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...

journal_title：Cancer investigation

authors： Cho H,Lee YS,Kim J,Chung JY,Kim JH

更新日期：2013-11-01 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：:Withaferin A (WA) (1) and two analogs [4-epi-withaferin A (2) and 4,27-diacetyl-4-epi-withaferin A (3)] were evaluated for antitumor activity in pancreatic cancer cells. IC(50) for 1, 2, and 3 were 0.87, 0.45, and 0.29 ?M (BxPC-3); 1.28, 1.53, and 0.52 ?M (MIAPaCa-2); and 0.59, 2.25, and 0.56 ?M (PANC-1), respectively...

journal_title：Cancer investigation

authors： Liu X,Qi W,Cooke LS,Kithsiri Wijeratne EM,Xu YM,Marron MT,Leslie Gunatilaka AA,Mahadevan D

更新日期：2011-12-01 00:00:00

abstract：:Decisions about the treatment of recurrent ovarian cancer are usually based on the treatment-free interval. Patients relapsing with an interval of more than six months are usually retreated with platinum-based chemotherapy. Non platinum drugs (such as paclitaxel, gemcitabine, liposomal doxorubicin or topotecan) are al...

journal_title：Cancer investigation

authors： Ledermann JA,Wheeler S

更新日期：2004-01-01 00:00:00

abstract：:IFN regulatory factor 4 binding protein (IBP) has been shown to play an important role in the progression of malignant tumors such as breast cancer cells, but its function in oral squamous cell carcinoma (OSCC) remains unclear. We found that IBP ectopically expressed in some OSCC specimens but not in normal oral mucos...

journal_title：Cancer investigation

authors： Jian CX,Yang MZ,Li P,Xiong J,Zhang ZJ,Li CJ,Chen A,Hu CM,Zhou JX,Li SH

更新日期：2012-12-01 00:00:00

abstract：:Although PKCs are assumed to be the main targets of phorbol esters (PMA), additional PMA effectors, such as chimaerins (a family of RacGTPase activating proteins) and RasGRP (exchange factor for Ras/Rap1), can counteract or strengthen the PKC pathways. In this study, we evaluated the proliferative behavior of PMA-trea...

journal_title：Cancer investigation

authors： Fortino V,Torricelli C,Capurro E,Sacchi G,Valacchi G,Maioli E

更新日期：2008-02-01 00:00:00

abstract：:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...

journal_title：Cancer investigation

authors： Schattner EJ

更新日期：2002-01-01 00:00:00

abstract：:We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...

journal_title：Cancer investigation

authors： Andersen P,Villingshøj M,Poulsen HS,Stockhausen MT

更新日期：2009-02-01 00:00:00

abstract：:Following is a review of altered fractionation in radiation therapy for head and neck cancer. The goals of altered fractionation are to increase local-regional control and/or reduce the risk of late complications. Altered fractionation schedules can be broadly classified as accelerated fractionation and hyperfractiona...

journal_title：Cancer investigation

authors： Mendenhall WM,Parsons JT

更新日期：1998-01-01 00:00:00

abstract：:After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...

journal_title：Cancer investigation

authors： Crane E,List A

更新日期：2005-01-01 00:00:00

abstract：:To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...

journal_title：Cancer investigation

authors： Xiaojiang T,Jinsong Z,Jiansheng W,Chengen P,Guangxiao Y,Quanying W

更新日期：2010-06-01 00:00:00

abstract：:This study is to evaluate the association between IL-8 -251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 -251A/T polymorphism was not associ...

journal_title：Cancer investigation

authors： Gao P,Zhao H,You J,Jing F,Hu Y

更新日期：2014-12-01 00:00:00

abstract：:Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors. This drug can be used either concomitantly with radiotherapy or as chemotherapy. The prognosis of relapsing medulloblastoma is poor and treatment is often difficult, especially after radiotherapy. Here, we report th...

journal_title：Cancer investigation

authors： Durando X,Thivat E,Gilliot O,Irthum B,Verrelle P,Vincent C,Bay JO

更新日期：2007-09-01 00:00:00

abstract：:Primary squamous cell carcinoma of the breast is a rare clinical entity. We diagnosed a patient who presented with a pure squamous cell cancer of the breast 12 years after local radiation for a primary adenocarcinoma of breast. Previously reported cancers related to radiation of the breast have been squamous cell of s...

journal_title：Cancer investigation

authors： Singh H,Williams SP,Kinsella V,Lynch GR

更新日期：2000-01-01 00:00:00

abstract：:ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...

journal_title：Cancer investigation

authors： Qu H,Qu D,Chen F,Zhang Z,Liu B,Liu H

更新日期：2010-07-01 00:00:00

abstract：:There appears to be exceptional and growing public enthusiasm for botanical, or "herbal", medicines, especially amongst cancer patients. This has recently begun to be matched by increasing scientific attention. Whilst it is known that plant extracts are active against cancer, the standard approach has been to isolate,...

journal_title：Cancer investigation

authors： Vickers A

更新日期：2002-01-01 00:00:00

abstract：:Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...

journal_title：Cancer investigation

authors： Karimi P,Hematti S,Safari F,Tavassoli M

更新日期：2013-11-01 00:00:00

abstract：:Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...

journal_title：Cancer investigation

authors： Agah S,Akbari A,Talebi A,Masoudi M,Sarveazad A,Mirzaei A,Nazmi F

更新日期：2017-11-26 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...

journal_title：Cancer investigation

authors： Cascinu S,Del Ferro E,Ligi M,Staccioli MP,Giordani P,Catalano V,Agostinelli R,Muretto P,Catalano G

更新日期：2001-01-01 00:00:00

abstract：:Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...

journal_title：Cancer investigation

authors： Gazitt Y,Gurfel D,Leizerowitz R,Feinstein H,Polliack A

更新日期：1987-01-01 00:00:00

abstract：:The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for ...

journal_title：Cancer investigation

authors： Retsky MW,Swartzendruber DE,Bame PD,Wardwell RH

更新日期：1994-01-01 00:00:00

abstract：:Here 145 reported post-splenectomy infections in 115 patients with Hodgkin's disease are reviewed. Such infections can occur at any age (median age 19.8 years) and the interval from splenectomy to the infection is quite variable (median 21.9 months). Most infections are present clinically as pneumonia, septicemia, men...

journal_title：Cancer investigation

authors： Rosner F,Zarrabi MH

更新日期：1983-01-01 00:00:00

abstract：:To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...

journal_title：Cancer investigation

authors： Augoff K,Grabowski K,Rabczynski J,Kolondra A,Tabola R,Sikorski AF

更新日期：2009-05-01 00:00:00

abstract：:The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used wa...

journal_title：Cancer investigation

authors： Kolotas C,Daniel M,Demetriou L,Martin T,Kurek R,Tonus C,Göbel U,Schnabel T,Zamboglou N

更新日期：2001-01-01 00:00:00

abstract：:Currently, bladder cancer ranks as the second most common genitourinary malignancy which is exacting significant morbidity and mortality worldwide. Although there are abundant epidemiological and basic studies which strongly suggest the role of androgen hormone in bladder cancer, the underlying mechanism is not fully ...

journal_title：Cancer investigation

authors： Wu J,Liu J,Jia R,Song H

更新日期：2013-12-01 00:00:00

abstract：BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was underta...

journal_title：Cancer investigation

authors： Anderson SE,O'Reilly EM,Kelsen DP,Ilson DH

更新日期：2003-01-01 00:00:00

abstract：:Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and...

journal_title：Cancer investigation

authors： Queiroz RM,Takiya CM,Guimarães LP,Rocha Gda G,Alviano DS,Blank AF,Alviano CS,Gattass CR

更新日期：2014-07-01 00:00:00

abstract：:In vivo and in vitro observations of cellular immune response in 70 patients with squamous cell cancer of the oral cavity and in 40 age-matched normal controls, were made using delayed hypersensitivity responses to DNCB, PPD, and Candida albicans extract (Dermatophytin 'O'), absolute lymphocyte counts, absolute T-cell...

journal_title：Cancer investigation

authors： Das SN,Khanna NN,Khanna S

更新日期：1986-01-01 00:00:00