Abstract:
:After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cellular immune and cytokine response while lacking some of the dose limiting side effects of the parent compound, such as neurologic toxicity. Preclinical data will be reviewed that outlines these drugs' effects on tumor necrosis alpha, interleukin 12, angiogenesis, and T-cell function. The evolution of the use of thalidomide as a therapeutic for diseases such as multiple myeloma and myelodysplastic syndrome and the promising initial results of the new IMiDs will be reviewed.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Crane E,List Adoi
10.1080/07357900500283101subject
Has Abstractpub_date
2005-01-01 00:00:00pages
625-34issue
7eissn
0735-7907issn
1532-4192pii
N5183N192Q883174journal_volume
23pub_type
杂志文章,评审abstract::Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120027587
更新日期:2004-01-01 00:00:00
abstract::A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1453072
更新日期:2018-03-16 00:00:00
abstract::Doxorubicin and paclitaxel are highly active agents in the treatment of advanced breast cancer. Although early trials of the combination reported high response rates, an unexpectedly high incidence of congestive heart failure observed on two of the early trials was cause for much concern. More recently, clinical trial...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-100000150
更新日期:2001-01-01 00:00:00
abstract:BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120000360
更新日期:2002-01-01 00:00:00
abstract::Transarterial radioembolization (TARE) is one of the therapeutic options for hepatocellular carcinoma (HCC). This study aimed to investigate the predictors and prognostic values of achieving curative treatments after TARE. Overall, 143 patients with intrahepatic HCC treated with TARE between 2011 and 2017 were recruit...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1870126
更新日期:2021-01-11 00:00:00
abstract::Synovial sarcoma (SS) is an aggressive tumor that accounts for almost 10% of all soft tissue sarcomas. In this study, we found the expression of CD133 in human SS specimens, thus, we focused on the function of CD133 in SS. Separation of the CD133-positive and -negative subpopulations in SS cell lines clarified that th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.672607
更新日期:2012-06-01 00:00:00
abstract::Neurological paraneoplastic syndromes are exceedingly rare, and often difficult to recognize clinically. Paraneoplastic achalasia is a condition characterized by new-onset dysphagia that is unrelated to tumor burden, most often due to the development of auto-immune antibodies targeting esophageal tissue. Due to the ra...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1852412
更新日期:2021-01-06 00:00:00
abstract::The interleukin-2 (IL2) gene is assigned to human chromosome 4. A synthetic oligonucleotide representing bases 285 to 324 of the IL2 cDNA clone described by Taniguchi et al. [Nature (London) 302:305-310, 1983] was used as hybridization probe in Southern blots. Eco RI digests of DNA derived from 11 somatic mouse-human ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908409018440
更新日期:1984-01-01 00:00:00
abstract::There appears to be exceptional and growing public enthusiasm for botanical, or "herbal", medicines, especially amongst cancer patients. This has recently begun to be matched by increasing scientific attention. Whilst it is known that plant extracts are active against cancer, the standard approach has been to isolate,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120005926
更新日期:2002-01-01 00:00:00
abstract::This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.834925
更新日期:2013-10-01 00:00:00
abstract::The transforming growth factor beta 1 (TGF-beta1) is a multifunctional cytokine with several regulatory activities in tumor cells affecting growth, differentiation, and function. Alterations in gene expression, secretion, and regulation of TGF-beta1 may lead to a favorable environment for tumor development by angiogen...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701600921
更新日期:2007-12-01 00:00:00
abstract::We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802570759
更新日期:2009-02-01 00:00:00
abstract::Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2015.1114123
更新日期:2016-01-01 00:00:00
abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900902744494
更新日期:2010-03-01 00:00:00
abstract::Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inherita...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909709047596
更新日期:1997-01-01 00:00:00
abstract::Interstitial collagenase-1 degrades a variety of extracellular matrix components. A single guanine insertion polymorphism in the promoter has been found that influences on the transcription and expression level of the gene. It is suggested that this polymorphism may enhance susceptibility to some types of cancer. Ther...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900801953204
更新日期:2008-10-01 00:00:00
abstract::Serum C-reactive protein (CRP), a sensitive marker of systemic inflammation, has been reported to be associated with the risk of a number of cancers including breast cancer. However, the results are inconsistent. To investigate the association between serum CRP levels and early breast cancer, we conducted a hospital-b...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.789898
更新日期:2013-05-01 00:00:00
abstract::Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701518487
更新日期:2007-10-01 00:00:00
abstract::Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1582060
更新日期:2019-01-01 00:00:00
abstract::We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.861470
更新日期:2014-01-01 00:00:00
abstract::In this study, we evaluated SEA-H61D, a staphylococcal enterotoxin A mutant without emetic activity, as an antitumor agent in vitro and in vivo. It showed that SEA-H61D could significantly inhibit the growth of many cancer cell lines in vitro at very low concentrations by activating human peripheral blood mononuclear ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903286982
更新日期:2010-10-01 00:00:00
abstract::Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-67147
更新日期:2005-01-01 00:00:00
abstract::The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.568566
更新日期:2011-06-01 00:00:00
abstract::Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1408814
更新日期:2017-11-26 00:00:00
abstract::Primary squamous cell carcinoma of the breast is a rare clinical entity. We diagnosed a patient who presented with a pure squamous cell cancer of the breast 12 years after local radiation for a primary adenocarcinoma of breast. Previously reported cancers related to radiation of the breast have been squamous cell of s...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012177
更新日期:2000-01-01 00:00:00
abstract::The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657815
更新日期:2012-05-01 00:00:00
abstract::Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600814847
更新日期:2006-08-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903405918
更新日期:2010-10-01 00:00:00
abstract:PURPOSE:This Phase II study was undertaken to define the efficacy and toxicity of the combination of docetaxel and irinotecan for the second-line treatment of non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-six patients with measurable NSCLC who had relapsed after an initial response to chemotherapy or ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.1080/07357900600705318
更新日期:2006-06-01 00:00:00
abstract::Multifractionated dosing (MFD) schedules for chemotherapy administration such as weekly or twice weekly administration are intended to maximize dose intensity while minimizing toxicity, but the cumulative drug effect may result in neutropenia necessitating interruption of dose fractions and thereby compromising dose i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909909032865
更新日期:1999-01-01 00:00:00