Association Between Curative Treatment after Transarterial Radioembolization and Better Survival Outcomes in Patients with Hepatocellular Carcinoma.

abstract：:Dysregulation in apoptotic cell death has recently emerged as a factor in tumorigenesis, but its effect in tumor progression is not yet established. In the present study we evaluated the levels of proliferative and apoptotic cell fractions in a T-cell lymphoma tumor progression model. We compared these features and th...

journal_title：Cancer investigation

authors： Donin N,Kay S,Sinai J,Katzenelson D,Siegal A,Michowitz M,Schibi G,Leibovici J

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVES:To investigate the relative risk factor of food items for colorectal cancer in four time periods through a case-control study in a Chinese rural area. METHODS:Colorectal cancer patients diagnosed at a county cancer center, Hebei Province, China, and non-cancer outpatients with similar age, sex, and place of...

journal_title：Cancer investigation

authors： Zhang B,Li X,Nakama H,Zhang X,Wei N,Zhang X,Zhang L

更新日期：2002-01-01 00:00:00

abstract：:Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...

journal_title：Cancer investigation

authors： Xi J,Zeng ST,Guo L,Feng J

更新日期：2016-01-01 00:00:00

abstract：:We analyzed the pattern of alpha-fetoprotein (AFP) synthesis in 40 consecutive human hepatocarcinomas (HCC) in relation to hepatitis B viral (HBV) infection. In addition, histopathological characteristics of liver parenchyma and the tumor itself were examined. Elevated AFP (> 20 ng/ml) were found in 90% of HCC patient...

journal_title：Cancer investigation

authors： Kashala LO,Kalengayi MM,Essex M

更新日期：1992-01-01 00:00:00

abstract：:Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...

journal_title：Cancer investigation

authors： Razis E,Karina M,Karanastassi S,Fountzilas G

更新日期：2006-08-01 00:00:00

abstract：:FTIR spectroscopy is a common technique for cancer diagnosis. Applied tissue samples are heterogeneous and may be damaged in preparation procedures. Easier sampling, more available samples and also easier process with assured results would be interesting. Whole blood samples include all of these qualifications and our...

journal_title：Cancer investigation

authors： Khanmohammadi M,Ansari MA,Garmarudi AB,Hassanzadeh G,Garoosi G

更新日期：2007-09-01 00:00:00

abstract：:We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor and nontumor cell types that under- or overexpress proteins involved...

journal_title：Cancer investigation

authors： Rosen EM,Fan S,Rockwell S,Goldberg ID

更新日期：1999-01-01 00:00:00

abstract：:The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy...

journal_title：Cancer investigation

authors： Miteva L,Stanilov N,Deliysky T,Mintchev N,Stanilova S

更新日期：2009-11-01 00:00:00

abstract：:Twenty four patients with epithelial ovarian cancer, who were treated by chemotherapy after debulking surgery, were monitored by serial monthly CA125 estimation and half-yearly computerized axial tomogram (CAT) of abdomen and pelvis. The efficiency of these monitoring methods and that of clinical examination were comp...

journal_title：Cancer investigation

authors： Ngan HY,Wong LC,Chan SY,Ma HK

更新日期：1990-01-01 00:00:00

abstract：:CXCL12 is an extracellular chemokine binding to cell surface receptor CXCR4. We found that activation of CXCL12/CXCR4 axis stimulated angiogenesis in endothelial cells. Knockdown of CXCR4 in endothelial cells prevented the branch points of angiogenesis. Endothelial cells exposed to CXCL12 presented high level of epide...

journal_title：Cancer investigation

authors： Song ZY,Wang F,Cui SX,Qu XJ

更新日期：2018-01-02 00:00:00

abstract：:8-Chloro-cyclic-adenosine-3',5'-monophosphate (8-Cl-cAMP), a site-selective synthetic cyclic adenosine 3',5'-monophosphate (cAMP) analog exhibits growth inhibition in a broad spectrum of human cancer lines. However, detailed studies on the effects exerted by cAMP analogs on cell-cycle kinetics have been lacking. We ha...

journal_title：Cancer investigation

authors： Grbovic O,Jovic V,Ruzdijic S,Pejanovic V,Rakic L,Kanazir S

更新日期：2002-01-01 00:00:00

abstract：:We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...

journal_title：Cancer investigation

authors： Andersen P,Villingshøj M,Poulsen HS,Stockhausen MT

更新日期：2009-02-01 00:00:00

abstract：:SNPs in CYP1A1, CYP2A1, CYP2B6, CYP2C, CYP2D6, CYP3A, GSTM1, GSTT1, GSTP1, SULT1A1, SULT1A2, UGT, and MTHFR are associated with breast cancer susceptibility; however, lack of such associations are also reported in some populations. The contradictory findings are explained on the basis of ethnic variation among populat...

journal_title：Cancer investigation

authors： Singh V,Parmar D,Singh MP

更新日期：2008-10-01 00:00:00

abstract：:The aim of the current study was to determine the signaling differences between gamma- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or gamma-radiation. Proton beam was found to be more cytotoxic than gamma-radiation. Proton beam-irradiated cells showed phosphorylat...

journal_title：Cancer investigation

authors： Ghosh S,Bhat NN,Santra S,Thomas RG,Gupta SK,Choudhury RK,Krishna M

更新日期：2010-07-01 00:00:00

abstract：:Standard chemotherapeutic regimens, such as cisplatin and etoposide, may improve quality of life and prolong survival in patients with incurable non-small cell lung cancer (NSCLC). This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stag...

journal_title：Cancer investigation

authors： Ali MA,Kraut MJ,Valdivieso M,Wozniak AJ,Cummings G,Kalemkerian GP

更新日期：2000-01-01 00:00:00

abstract：:A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR:...

journal_title：Cancer investigation

authors： Xie X,Liu J,Yang H,Chen H,Zhou S,Lin H,Liao Z,Ding Y,Ling L,Wang X

更新日期：2019-01-01 00:00:00

abstract：:Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were f...

journal_title：Cancer investigation

authors： Abdelhafeez AAM,Shohdy KS,Ibrahim W

更新日期：2020-03-01 00:00:00

abstract：:CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...

journal_title：Cancer investigation

authors： Voigt H,Vetter-Kauczok CS,Schrama D,Hofmann UB,Becker JC,Houben R

更新日期：2009-03-01 00:00:00

abstract：:Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...

journal_title：Cancer investigation

authors： Tehan L,Taparra K,Phelan S

更新日期：2013-07-01 00:00:00

abstract：:Metastasis is the overwhelming cause of mortality in patients with breast cancer and our understanding of its cellular and molecular determinants is limited. Among cellular determinants, disseminated (DTC) tumor cells undoubtedly are key players in the metastatic cascade. In the past, several models have been construc...

journal_title：Cancer investigation

authors： Braun S,Auer D,Marth C

更新日期：2009-07-01 00:00:00

abstract：:Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...

journal_title：Cancer investigation

authors： Amirghofran Z,Bahmani M,Azadmehr A,Ashouri E,Javidnia K

更新日期：2007-10-01 00:00:00

abstract：:Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...

journal_title：Cancer investigation

authors： Tan GW,Lan FL,Gao JG,Jiang CM,Zhang Y,Huang XH,Ma YH,Shao HD,He XY,Chen JL,Long JW,Xiao HS,Guo ZT,Diao Y

更新日期：2012-08-01 00:00:00

abstract：:In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor ti...

journal_title：Cancer investigation

authors： Singh N,Das P,Datta Gupta S,Sahni P,Pandey RM,Gupta S,Chauhan SS,Saraya A

更新日期：2013-08-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by specific t(15;17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct s...

journal_title：Cancer investigation

authors： Bashash D,Ghaffari SH,Zaker F,Hezave K,Kazerani M,Ghavamzadeh A,Alimoghaddam K,Mosavi SA,Gharehbaghian A,Vossough P

更新日期：2012-01-01 00:00:00

abstract：:Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...

journal_title：Cancer investigation

authors： Bierman HR,Faith MR,Stewart ME

更新日期：1988-01-01 00:00:00

abstract：:The limited capacity to divide is one of the major differences between normal somatic cells and cancerous cells. This 'finite life span' of somatic cells is closely linked to loss of telomeric DNA at telomeres, the 'chromosome caps' consisting of repeated (7TAGGG) sequences., In more than 85% of advanced cancers, this...

journal_title：Cancer investigation

authors： Helder MN,Wisman GB,van der Zee GJ

更新日期：2002-01-01 00:00:00

abstract：:After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...

journal_title：Cancer investigation

authors： Crane E,List A

更新日期：2005-01-01 00:00:00

abstract：:Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...

journal_title：Cancer investigation

authors： Luwor R,Morokoff AP,Amiridis S,D'Abaco G,Paradiso L,Stylli SS,Nguyen HPT,Tarleton M,Young KA,O'Brien TJ,Robinson PJ,Chircop M,McCluskey A,Jones NC

更新日期：2019-01-01 00:00:00

abstract：:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

journal_title：Cancer investigation

authors： Herbert PN,Friedland ML

更新日期：1986-01-01 00:00:00

abstract：:Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alp...

journal_title：Cancer investigation

authors： Shaheen PE,Bukowski RM

更新日期：2006-10-01 00:00:00