Abstract:
:Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alpha or interleukin-2. Identifying molecular targets and targeting various biomarkers has revolutionized the therapeutic approach to advanced and metastatic renal cell carcinoma. Although some of the antiangiogenic agents and receptor tyrosine kinase inhibitors appear promising, further understanding of their mechanism of action and the patient population who would benefit most from such agents is still being explored. As numerous targeted agents are entering the clinical investigation arena in a relatively short period of time, newer challenges in renal cell carcinoma therapeutics are emerging. Some of the future challenges in using targeted antineoplastic agents in renal cell carcinoma will include evaluating their long-term safety and benefit, using the particular drug in the appropriate patient population after appropriate stratification and studying the combination of some of these drugs for synergy or additive effects.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Shaheen PE,Bukowski RMdoi
10.1080/07357900600896315subject
Has Abstractpub_date
2006-10-01 00:00:00pages
640-56issue
6eissn
0735-7907issn
1532-4192pii
P154333082511Q40journal_volume
24pub_type
杂志文章,评审abstract::In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.743557
更新日期:2013-01-01 00:00:00
abstract::Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802672720
更新日期:2009-08-01 00:00:00
abstract::Fulvestrant (Faslodex) is a new type of estrogen receptor (ER) antagonist that binds, blocks, and degrades the ER, leading to reduced expression of the progesterone receptor (PgR). Unlike the selective ER modulator tamoxifen, fulvestrant is devoid of any known agonist activity. Fulvestrant has a steroidal structure th...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-50480
更新日期:2005-01-01 00:00:00
abstract::Expression of epidermal growth factor and its transmembrane receptor (EGFR) stimulates tumor growth. Matuzumab is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth, and provides a clinical benefit for some patients. The plasma half-life (6-10 days) an...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701511847
更新日期:2008-02-01 00:00:00
abstract::There are many changes in the immune response with age, most of which can be related to the involution of the thymus gland and alteration of the distribution and function of T lymphocytes. These changes indirectly influence B-cell function, which not only amplifies the immune deficits, but leads to the increased produ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909209024815
更新日期:1992-01-01 00:00:00
abstract::Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1653465
更新日期:2019-01-01 00:00:00
abstract::Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1309547
更新日期:2017-07-03 00:00:00
abstract:OBJECTIVES:To evaluate the efficacy and toxicity of the combination of vinorelbine and interleukin (IL)-2 in patients with metastatic melanoma as second-line chemotherapy. PATIENTS AND METHODS:Twenty-two patients with histologically confirmed stage IV melanoma previously treated with temozolomide-based chemotherapy--o...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1081/cnv-200039630
更新日期:2004-01-01 00:00:00
abstract::The generation of genetically modified immunological effector cells is of potential therapeutic value in the treatment of malignancies. Cytokine-induced killer cells (CIKs) have been described as highly efficient cytotoxic effector cells capable of recognizing and lysing tumor cell targets in a non-major histocompatib...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802239124
更新日期:2009-03-01 00:00:00
abstract::A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1453072
更新日期:2018-03-16 00:00:00
abstract::The interaction of 5-fluorouracil and cyclophosphamide in the treatment of L1210 and P388 leukemias was studied using response surface methodology. Single dose treatment of each drug was administered simultaneously or with a 24-hr interval between 5-fluorouracil and cyclophosphamide to the advanced tumors or at variou...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908709020311
更新日期:1987-01-01 00:00:00
abstract::Despite increasing evidence of benefit from adjuvant chemotherapy, older women with breast cancer are commonly given less aggressive treatment than younger patients. Conflicting prior data regarding age-related toxicity prompted this prospective study. Forty-four women (aged 35-79 years) with early-stage breast cancer...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012191
更新日期:2000-01-01 00:00:00
abstract::The aim was to determine whether promoter methylation of BRCA1, MGMT, MLH1, RASSF1A, and p16 genes could predict response to platinum-based chemotherapy. Thirty-five subjects with epithelial ovarian cancer (EOC) treated by platinum-based chemotherapy were recruited. Methylation-specific polymerase chain reaction was c...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849699
更新日期:2009-10-01 00:00:00
abstract::Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.845672
更新日期:2013-11-01 00:00:00
abstract::The present study examines the effect of tobacco smoking on the expression of cyclooxygenase (COX)-2 gene, COX enzymatic activity and prostaglandin (PG) synthesis in urothelial mucosal tissues from patients with bladder cancer and from normal individuals. The detection frequency of COX-2 mRNA was 2-fold higher in blad...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120002490
更新日期:2002-01-01 00:00:00
abstract::Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077025
更新日期:1988-01-01 00:00:00
abstract::UFT is the combination of the fluorouracil (5-FU) prodrug tegafur, and the dihydrophyrimidine dehydrogenase inhibitor uracil. UFT and leucovorin have been used in the oral treatment of a variety of malignancies. Given the radiosensitizing properties of UFT, its combination with radiation therapy is a logical step in t...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120022382
更新日期:2003-01-01 00:00:00
abstract::Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2019.1662918
更新日期:2019-01-01 00:00:00
abstract::After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500283101
更新日期:2005-01-01 00:00:00
abstract::This is a case report of small cell lung cancer (SCLC) that underwent spontaneous regression. This was associated with severe neuropathy, which was unresponsive to therapy, including corticosteroids and plasmapheresis. We present here the case report and a brief review of the literature. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309024856
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND:Although treatment-related lymphopenia (TRL) is common in many cancers no data exists in rectal cancer. METHODS:Serial lymphocyte counts were analyzed retrospectively in patients with newly diagnosed rectal cancer, serial blood counts, and complete records at Johns Hopkins Hospital. RESULTS:Fifty-seven pat...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1499028
更新日期:2018-01-01 00:00:00
abstract::This review summarizes the literature on QoL in early stage lung cancer patients who underwent surgery. PubMed and PsycINFO were searched. Twelve articles from 10 distinct studies were identified for a total of 992 patients. Five QoL measures were used. One study reported only on pre-surgical QoL, six only on post-sur...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2018.1474892
更新日期:2018-01-01 00:00:00
abstract::The results of a prospective trial with a specifically devised chemotherapy regimen in elderly patients with unfavorable non-Hodgkin's lymphoma (NHL) are reported. Between April 1983 and April 1986, 37 consecutive patients 70 years old or more (median age 80) received etoposide and prednimustine (E + P) 100 mg/m2 p.o....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909009018923
更新日期:1990-01-01 00:00:00
abstract::Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::A case control study of 2,908 breast cancer cases and 3,180 controls, derived from a nationwide screening program, enabled evaluation of the relationship of breast cancer risk to a variety of menstrual factors. Risk was significantly inversely related to age at menarche, with women who first menstruated at age 15 or l...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809080645
更新日期:1988-01-01 00:00:00
abstract::Twenty-two patients with disseminated adenocarcinoma of the large bowel received therapy with 5-fluorouracil 800-1000 mg/m2 as a 24 h infusion for 4 consecutive days with 60 mg/m2 intravenous folinic acid administered every 6 hours. Major responses were seen in 3 of 20 (15%) evaluable patients, for a median of 5 month...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077039
更新日期:1988-01-01 00:00:00
abstract::The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908509040603
更新日期:1985-01-01 00:00:00
abstract::Requirements for the induction of anomalous killer (AK) cells to syngeneic MOPC 104E-KI81 plasmacytoma, and their pattern of reaction were investigated. The AK cells are Thy-1.2 positive and were induced by cocultivation of normal BALB/c spleen cells for 5 days in vitro with mitomycin C-treated MOPC 104E-KI81 cells in...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909038265
更新日期:1989-01-01 00:00:00
abstract::Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.681821
更新日期:2012-07-01 00:00:00
abstract::Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.697232
更新日期:2012-08-01 00:00:00