Abstract:
:We analyzed the pattern of alpha-fetoprotein (AFP) synthesis in 40 consecutive human hepatocarcinomas (HCC) in relation to hepatitis B viral (HBV) infection. In addition, histopathological characteristics of liver parenchyma and the tumor itself were examined. Elevated AFP (> 20 ng/ml) were found in 90% of HCC patients and in none of the controls. In 35% of HCC cases, serum AFP was above 100,000 ng/ml. AFP levels were significantly higher in patients seropositive for hepatitis B surface antigen (HBsAg) compared with their negative counterparts (mean log[AFP]: 4.28 +/- 1.67 vs. 3.28 +/- 1.96, respectively; geometric mean (GM): 19,322.6 ng/ml and 1939.5 ng/ml, respectively; p < 0.05). Furthermore, serum AFP levels were higher in HCC patients with liver cirrhosis than in those without (log[AFP]: 4.43 +/- 1.58 vs. 3.23 +/- 1.98, respectively; p < 0.05). However, the relationship of cirrhosis with AFP was confounded by the high prevalence of HBsAg in cirrhotic HCC patients. There was no correlation of AFP with either liver necrosis (abnormal AFP in 45% of cases; mean log[AFP]: 3.99 +/- 1.91 vs. 3.75 +/- 1.85 for HCC with and without necrosis, respectively; 0.05 < p < 0.68, not significant (NS)), or inflammation (abnormal AFP in 25%; mean log[AFP]: 4.33 +/- 1.62 vs. 3.70 +/- 1.93 for HCC with and without inflammation, respectively; 0.05 < p < 0.39, NS). A vast majority of HCC (75%) were moderately (grade 2-3) or poorly differentiated tumors (grade 3, grade 4, or combined grade 3-4). Serum AFP did not correlate with tumor grade. Immunohistochemical analysis of HBsAg and AFP confirmed the serological findings, and confirmed earlier observations of elevated AFP in HBsAg-positive patients. These results may reflect pathogenic and biological differences between HBsAG-secreting and nonsecreting HCC.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Kashala LO,Kalengayi MM,Essex Mdoi
10.3109/07357909209024813subject
Has Abstractpub_date
1992-01-01 00:00:00pages
513-22issue
6eissn
0735-7907issn
1532-4192journal_volume
10pub_type
杂志文章abstract::Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357900009023065
更新日期:2000-01-01 00:00:00
abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900902744494
更新日期:2010-03-01 00:00:00
abstract::Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.845672
更新日期:2013-11-01 00:00:00
abstract::The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk com...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909709115767
更新日期:1997-01-01 00:00:00
abstract::There is no known effective salvage chemotherapy for patients with refractory or relapsed urothelial tumors after methotrexate/cisplatin-based regimen. We report the results of a phase II trial with the FIFO regimen that includes from day 1 to 5: fluorouracil 350 mg/m2, folinic acid 20 mg/m2, and ifosfamide 1000 mg/m2...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909509094462
更新日期:1995-01-01 00:00:00
abstract::To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802527221
更新日期:2009-05-01 00:00:00
abstract::To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903095706
更新日期:2010-06-01 00:00:00
abstract::The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657817
更新日期:2012-05-01 00:00:00
abstract::Reversible epidermal growth factor receptor tyrosine kinase inhibitors are often used for the treatment of non-small cell lung cancer following failure of cytotoxic chemotherapy. While these agents are active in a subset of patients, most develop resistance and progress within the course of 1 year. In nearly half of t...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357901003631072
更新日期:2010-05-01 00:00:00
abstract::Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600629575
更新日期:2006-04-01 00:00:00
abstract::Tissues become more rigid during tumorigenesis and have been identified as a driving factor for tumor growth. Here, we highlight the concept of tissue rigidity, contributing factors that increase tissue rigidity, and mechanisms that promote tumor growth initiated by increased tissue rigidity. Various factors lead to i...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2020.1802474
更新日期:2020-09-01 00:00:00
abstract::UFT is the combination of the fluorouracil (5-FU) prodrug tegafur, and the dihydrophyrimidine dehydrogenase inhibitor uracil. UFT and leucovorin have been used in the oral treatment of a variety of malignancies. Given the radiosensitizing properties of UFT, its combination with radiation therapy is a logical step in t...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120022382
更新日期:2003-01-01 00:00:00
abstract::Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibition by tyrphostin AG1024 in the presence or absence of doxorubicin in a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.606252
更新日期:2011-10-01 00:00:00
abstract::The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.657815
更新日期:2012-05-01 00:00:00
abstract:PURPOSE:This Phase II study was undertaken to define the efficacy and toxicity of the combination of docetaxel and irinotecan for the second-line treatment of non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-six patients with measurable NSCLC who had relapsed after an initial response to chemotherapy or ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.1080/07357900600705318
更新日期:2006-06-01 00:00:00
abstract::A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.700986
更新日期:2013-05-01 00:00:00
abstract::Fibronectin (Fn) synergizes with macrophages (M phi) in inducing cytostasis and cytotoxicity of neoplastic cells in culture. Since heparin enhances Fn's opsonic activity in many systems, we investigated its effect on Fn-macrophage synergy in cytostasis. MCG-T14 (a spontaneous mouse mammary adenocarcinoma) cells (4 X 1...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908409040310
更新日期:1984-01-01 00:00:00
abstract::Gefitinib (ZD1839, Iressa), a member of the 4-anilinoquinazoline class of compounds, has the chemical name 4-quinazolinamine, N-(3-chloro-4-flurophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]. Gefitinib often is referred to as a "specific" or "selective" inhibitor of epidermal growth factor receptor (EGFR). EGFR expre...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600632058
更新日期:2006-04-01 00:00:00
abstract::CXCL12 is an extracellular chemokine binding to cell surface receptor CXCR4. We found that activation of CXCL12/CXCR4 axis stimulated angiogenesis in endothelial cells. Knockdown of CXCR4 in endothelial cells prevented the branch points of angiogenesis. Endothelial cells exposed to CXCL12 presented high level of epide...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1422512
更新日期:2018-01-02 00:00:00
abstract::Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1408814
更新日期:2017-11-26 00:00:00
abstract::N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309020257
更新日期:1993-01-01 00:00:00
abstract::Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alp...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900600896315
更新日期:2006-10-01 00:00:00
abstract::We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to b...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802563010
更新日期:2009-07-01 00:00:00
abstract::A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1453072
更新日期:2018-03-16 00:00:00
abstract::Despite the dramatic success achieved over the past few years in improving the survival of individuals with cancer, treatment for many patients with advanced malignancies remains far from satisfactory. Unfortunately, centers engaged in clinical cancer research are currently faced with the dilemma of dealing with incre...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357908709011740
更新日期:1987-01-01 00:00:00
abstract::Environment may influence the development and prevention of cancer. Calcitriol has been associated with calcium homeostasis regulation. Many epidemiological, biochemical, and genetic studies have shown non-classic effects of vitamin D, such as its involvement in the progression of different cancers. Although vitamin D...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.721039
更新日期:2012-10-01 00:00:00
abstract::Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600814847
更新日期:2006-08-01 00:00:00
abstract:BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-200026487
更新日期:2004-01-01 00:00:00
abstract::For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701781812
更新日期:2008-06-01 00:00:00
abstract::Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2018.1453933
更新日期:2018-04-21 00:00:00