Abstract:
:The G1 cyclins are clearly important factors that control progression through the eukaryotic cell cycle. The expression and activity of these factors are regulated at many different levels and in response to a large number of signals. Such complicated, multilevel controls on expression and activation of cyclin/cdk complexes permit exquisite and necessary coordination of the stages of the cell cycle. Any of the large number of pathways involved in the regulation of cyclin activity also can be disrupted, leading to inappropriate expression and/or activity of complexes containing cyclins D1, D2, D3, and E. Characterization of these regulatory mechanisms and their synergistic effects on the G1 cyclins and cell cycle progression is a major area of investigation. While little evidence exists indicating that dysregulation of cyclin activity is an initiating event leading to malignant transformation, many studies indicate that disruption of the normal expression and/or activity of the G1 cyclins contributes to the transformed phenotype, potentially by overcoming negative proliferative signals in G1.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Hamel PA,Hanley-Hyde Jdoi
10.3109/07357909709115767subject
Has Abstractpub_date
1997-01-01 00:00:00pages
143-52issue
2eissn
0735-7907issn
1532-4192journal_volume
15pub_type
杂志文章,评审abstract::Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909709039724
更新日期:1997-01-01 00:00:00
abstract::After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500283101
更新日期:2005-01-01 00:00:00
abstract::Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077025
更新日期:1988-01-01 00:00:00
abstract::The interleukin-2 (IL2) gene is assigned to human chromosome 4. A synthetic oligonucleotide representing bases 285 to 324 of the IL2 cDNA clone described by Taniguchi et al. [Nature (London) 302:305-310, 1983] was used as hybridization probe in Southern blots. Eco RI digests of DNA derived from 11 somatic mouse-human ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908409018440
更新日期:1984-01-01 00:00:00
abstract::Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2019.1662918
更新日期:2019-01-01 00:00:00
abstract::Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-67147
更新日期:2005-01-01 00:00:00
abstract:BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.919305
更新日期:2014-08-01 00:00:00
abstract::We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.970193
更新日期:2014-12-01 00:00:00
abstract::Gastrointestinal stromal tumors (GIST) are tumors most frequently found in adults. They are often related to activating mutations in the CD-117 tyrosine kinase receptor, most commonly at exon 11. Gastrointestinal stromal tumors have been reported in children. However, until recently, there had not been reports of acti...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701637824
更新日期:2008-03-01 00:00:00
abstract::The efficacy of dose-intense methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) chemotherapy relative to conventional-dose M-VAC in patients with advanced transitional cell carcinoma is unknown. The outcomes of 33 patients on two successive protocols using dose-intense M-VAC with granulocyte colony-stimulat...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.3109/07357900009032829
更新日期:2000-01-01 00:00:00
abstract::Enhancement of radiation injury to the skin and mucous membranes has been observed with a number of chemotherapeutic agents. A 32-year-old woman with metastatic breast cancer received local radiation therapy to the lumbosacral area. Six weeks later, systemic edatrexate therapy was initiated and a localized painful ery...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024929
更新日期:1995-01-01 00:00:00
abstract::We developed inducible and constitutive expression systems of Ha-RasV12 in HEK 293 cells to examine early oncogenic RasV12 signaling. Inducible expression of oncogenic Ras-triggered growth arrest, early senescence, and later apoptosis. Gene expression profile analysis revealed early Ras proliferation and cell cycle ge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903095623
更新日期:2010-07-01 00:00:00
abstract::We carried out a phase I trial with chlorambucil. Thirty patients with advanced cancer were entered in six dose levels: 36, 48, 60, 84, 108, and 144 mg/m2. The drug was given in six divided oral doses every 6 hours and the regimen was repeated every 3 weeks. The median age was 62 years (31-84), median Karnofsky perfor...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809080064
更新日期:1988-01-01 00:00:00
abstract::To study the efficiency of high-dose melphalan in previously untreated patients with advanced myeloma, we performed a Phase I-II trial. Twenty-eight patients were treated at dose level of 60-140 mg/m2. Each patient was first treated with a priming dose of cyclophosphamide (300 mg) followed by high-dose melphalen 1 wee...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909209032784
更新日期:1992-01-01 00:00:00
abstract::This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.834925
更新日期:2013-10-01 00:00:00
abstract:BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701829777
更新日期:2008-04-01 00:00:00
abstract::Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.681821
更新日期:2012-07-01 00:00:00
abstract::The aim of the current study was to determine the signaling differences between gamma- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or gamma-radiation. Proton beam was found to be more cytotoxic than gamma-radiation. Proton beam-irradiated cells showed phosphorylat...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003630991
更新日期:2010-07-01 00:00:00
abstract::Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2016.1242010
更新日期:2016-11-25 00:00:00
abstract::Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2016.1221078
更新日期:2016-09-13 00:00:00
abstract::Primary squamous cell carcinoma of the breast is a rare clinical entity. We diagnosed a patient who presented with a pure squamous cell cancer of the breast 12 years after local radiation for a primary adenocarcinoma of breast. Previously reported cancers related to radiation of the breast have been squamous cell of s...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012177
更新日期:2000-01-01 00:00:00
abstract::The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.568566
更新日期:2011-06-01 00:00:00
abstract::Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701518487
更新日期:2007-10-01 00:00:00
abstract::The purpose of this study is to investigate whether hematopoiesis capacity, immunomodulatory effect and ex vivo expansion potential of mesenchymal stem cells (MSCs) are affected by cryopreservation. Chronic myeloid leukemia (CML) patients' bone marrow MSCs cryopreserved for 3 months, 6 months, and 1 year were thawed a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701788049
更新日期:2008-05-01 00:00:00
abstract::We analyzed the pattern of alpha-fetoprotein (AFP) synthesis in 40 consecutive human hepatocarcinomas (HCC) in relation to hepatitis B viral (HBV) infection. In addition, histopathological characteristics of liver parenchyma and the tumor itself were examined. Elevated AFP (> 20 ng/ml) were found in 90% of HCC patient...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909209024813
更新日期:1992-01-01 00:00:00
abstract::Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.849722
更新日期:2013-11-01 00:00:00
abstract::Non-invasive pharmacological management of patients with cancer related pain has resulted in pain control in 90-95% of the patients. Thus, 5-10% of patients still experience inadequate pain control despite aggressive combined pharmacological therapy. Moreover, patients may not tolerate an aggressive program of titrati...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-200027166
更新日期:2004-01-01 00:00:00
abstract::As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-58819
更新日期:2005-01-01 00:00:00
abstract::We studied the effects of Shikaron, which is composed of 8 Chinese herb extracts, on carcinogenesis and the cytotoxic activity and cytokine production of lymphocytes in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine (BBN). We found a significantly lower incidence of urinary bladder carcinoma in mice tr...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909809050031
更新日期:1998-01-01 00:00:00
abstract::Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors), cholesterol-lowering agents widely prescribed for cardiovascular health, have been shown to exert several pleiotropic effects. Although some studies reported that statins have no effects on malignancies of any kind, results of several epidemiologic ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900802491444
更新日期:2009-05-01 00:00:00