Abstract:
:The efficacy of dose-intense methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) chemotherapy relative to conventional-dose M-VAC in patients with advanced transitional cell carcinoma is unknown. The outcomes of 33 patients on two successive protocols using dose-intense M-VAC with granulocyte colony-stimulating factor (G-CSF) support were compared with those of 129 patients treated with conventional-dose M-VAC to assess for an impact of dose-intense therapy on long-term survival. The mean relative dose intensity of chemotherapy delivered to the dose-intense cohort was 55% higher than that delivered to the conventional-dose cohort (p = 0.0001). However, no significant differences were observed with regard to response proportion (72% vs. 76%), median survival (13.3 vs. 16.7 months, p = 0.31), or 5-year survival (16% vs. 15%). Growth factor support enabled a statistically significant increase in the delivered dose intensity of M-VAC chemotherapy, but no survival advantage relative to conventional-dose M-VAC was observed.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Dodd PM,McCaffrey JA,Mazumdar M,Scher H,Higgins G,Boyle MG,Herr H,Bajorin DFdoi
10.3109/07357900009032829subject
Has Abstractpub_date
2000-01-01 00:00:00pages
626-34issue
7eissn
0735-7907issn
1532-4192journal_volume
18pub_type
临床试验,杂志文章,随机对照试验abstract::We evaluated the clinical impact of a high definition micro-multileaf collimator and a linac-integrated cone-beam computed tomography in 142 patients treated with conformal radiotherapy for localized prostate cancer to a total dose of 76 Gy. Details on treatment toxicity and tumour control were collected. The 3 years ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.970193
更新日期:2014-12-01 00:00:00
abstract::Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.732164
更新日期:2012-12-01 00:00:00
abstract::Cisplatin (CDDP) was administered to a 49-year-old dialysis female patient with advanced uterine cervical cancer. Analysis of the pharmacokinetics of CDDP in the patient with renal failure and at hemodialysis were compared with that of patients without renal impairment. CDDP at 30 mg was administered by drip infusion....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909109039874
更新日期:1991-01-01 00:00:00
abstract::A Phase I trial of three carboplatin-based combination chemotherapy regimens was conducted. These included: carboplatin plus vindesine; carboplatin, vindesine, plus bleomycin; and, carboplatin plus vinblastine. Carboplatin was administered every 28 days as an intravenous bolus. The initial dose was 150 mg/m2 and doses...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909009017558
更新日期:1990-01-01 00:00:00
abstract::It is believed that telomerase is a terminal effector and its role is to maintain the length of telomeres. However, the main rate-limiting subunit of telomerase, human telomerase reverse transcriptase (hTERT), has been recently proved to have the ability to affect a variety of other genes such as p53 independently of ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900802491451
更新日期:2009-12-01 00:00:00
abstract::Because most cancer deaths result from disseminated disease, understanding the regulation of tumor invasion and metastasis is a central theme in tumor cell biology. Interactions between extracellular matrices (ECM) and cellular microenvironment play a crucial role in this process. We have tested selected amino acids a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909609018433
更新日期:1996-01-01 00:00:00
abstract::Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120016421
更新日期:2003-04-01 00:00:00
abstract::A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849657
更新日期:2009-10-01 00:00:00
abstract::ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2014.964409
更新日期:2014-12-01 00:00:00
abstract::Human papillomaviruses (HPVs) and BKV, JCV, and SV40 polyomaviruses (PYVs) are oncogenic viruses associated with different human tumors. Our aim was to determine if PYV and HPV sequences could be detected in human genital tumors. HPV types 6b, 11, 16, and 18 and PYV were investigated in 22 genital tumor samples and th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-200032937
更新日期:2004-01-01 00:00:00
abstract::Arsenic trioxide is valuable for treatment of promyelocytic leukemia, but less attention has been paid to its therapeutic potential for other cancers. In this study, the effects of arsenic trioxide were tested in human pancreatic (AsPC-1), colonic (HT-29), and breast (MCF-7) cancer cells. In all three cancer cell line...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-200029068
更新日期:2004-01-01 00:00:00
abstract::Neural stem cells (NSC) are capable of differentiating toward neuronal, astrocytic, oligodendrocytic and glial lineages, depending on their spatial location within the central nervous system (CNS). Although, a lot of knowledge has been gained in the understanding of differentiation-specific signaling in hematopoietic ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-200039679
更新日期:2004-01-01 00:00:00
abstract::The immunotherapeutic effects of interleukin-1 alpha (IL-1 alpha) encapsulated within 1-5 microns-diameter poly (D, L-lactide) microspheres and delivered intratumorally into fibrosarcoma-bearing mice were investigated. Such microspheres are avidly taken up by macrophages, and directing IL-1 alpha into these cells may ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120023770
更新日期:2003-01-01 00:00:00
abstract::The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409021402
更新日期:1994-01-01 00:00:00
abstract::Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.845672
更新日期:2013-11-01 00:00:00
abstract::Currently, bladder cancer ranks as the second most common genitourinary malignancy which is exacting significant morbidity and mortality worldwide. Although there are abundant epidemiological and basic studies which strongly suggest the role of androgen hormone in bladder cancer, the underlying mechanism is not fully ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.853077
更新日期:2013-12-01 00:00:00
abstract:BACKGROUND:Although treatment-related lymphopenia (TRL) is common in many cancers no data exists in rectal cancer. METHODS:Serial lymphocyte counts were analyzed retrospectively in patients with newly diagnosed rectal cancer, serial blood counts, and complete records at Johns Hopkins Hospital. RESULTS:Fifty-seven pat...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1499028
更新日期:2018-01-01 00:00:00
abstract::Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100106144
更新日期:2001-01-01 00:00:00
abstract::Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.681821
更新日期:2012-07-01 00:00:00
abstract::Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120001180
更新日期:2002-01-01 00:00:00
abstract::In a sample of 633 US adult breast cancer survivors, we examined health-related worry as a function vulnerability as influenced by communication, trust, and planning with their cancer care team during the COVID-19 pandemic. We found significant positive correlations between communication and trust, communication and p...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1841220
更新日期:2021-01-01 00:00:00
abstract::Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2016.1221078
更新日期:2016-09-13 00:00:00
abstract::Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120016404
更新日期:2003-01-01 00:00:00
abstract:PURPOSE:The decision concerning adjuvant therapy remains difficult in patients with very early stage ovarian carcinomas [Fédération Internationale de Gynécologie et d' Obstétrique (FIGO) Ia/b]. Therefore, we compared the MIB1-determined tumor growth fraction in archival tumor tissue with tumor recurrence and outcome of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120030206
更新日期:2004-01-01 00:00:00
abstract::A randomized trial was conducted comparing ketoconazole and nystatin in the prevention of oral candidiasis and appearance of invasive fungal infections in 51 neutropenic leukemic patients undergoing induction chemotherapy. Ketoconazole was administered in a 200 mg dose twice daily. Nystatin oral suspension was given i...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-01-01 00:00:00
abstract::Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-67147
更新日期:2005-01-01 00:00:00
abstract:PURPOSE:Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532, an inhibitor of telomerase on chondrosarcoma cells in vitro. METHODS:Telomerase activity, telomere lengths, growth kinetics and chemosensitivity were analyzed in...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802072905
更新日期:2008-07-01 00:00:00
abstract::Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:
更新日期:1987-01-01 00:00:00
abstract::Although it is not proven by causative association, several studies indicate that patients with acquired immune deficiency syndrome (AIDS) have a high risk for developing cutaneous malignancies, especially lymphoma and Kaposi's sarcoma. Other malignant cutaneous lesions seen in this patient population include basal-ce...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909809039770
更新日期:1998-01-01 00:00:00
abstract::Precise quantification of oral complications in cancer patients receiving bone marrow and stem cell transplantation is essential when testing new treatment strategies for mucositis. Using 133 adult transplant patients, the authors evaluated the 20 item oral mucositis index (OMI), adapted from the 34 item OMI, to facil...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120005902
更新日期:2002-01-01 00:00:00