Abstract:
:Pyrrolidindithiocarbamate (PDTC), is a metal chelator widely used to study the activation of redox sensitive transcription factors. Recently it has been demonstrated that it manifests pro-oxidant properties. The nuclear factor-Kappa B (NF-kappaB) transcription factor can both promote cell survival and induce apoptosis depending on cell type and context in response to genotoxic stress. In our previous study we reported that in acute myelogenous leukemia CD34+ cells PDTC stimulates apoptosis, whereas in CD34+ cells of healthy volunteers PDTC was ineffective. This cytotoxicity was dependent on the generation of superoxide anion and oxidized glutathione. In this article we have shown that the pro-oxidant effect of PDTC in AML cells induces NF-kappaB activity. These findings imply a role for NF-kappaB in the survival of normal cells with respect to leukemic cells, suggesting that NF-kappaB activity and function differs according to tumor cell phenotype.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Malaguarnera L,Pilastro MR,Vicari L,Dimarco R,Manzella L,Palumbo G,Messina Adoi
10.1081/cnv-67147subject
Has Abstractpub_date
2005-01-01 00:00:00pages
404-12issue
5eissn
0735-7907issn
1532-4192journal_volume
23pub_type
杂志文章abstract::A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039861
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-200026487
更新日期:2004-01-01 00:00:00
abstract:PURPOSE:This Phase II study was undertaken to define the efficacy and toxicity of the combination of docetaxel and irinotecan for the second-line treatment of non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-six patients with measurable NSCLC who had relapsed after an initial response to chemotherapy or ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.1080/07357900600705318
更新日期:2006-06-01 00:00:00
abstract::In conclusion, the prognosis for women with stage I borderline tumors is excellent. Surgery alone is the recommended treatment. For young patients, fertility-sparing surgery is optimal, with a small percentage eventually developing tumor in the contralateral ovary. For patients with advanced stage borderline tumors, 1...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909909021423
更新日期:1999-01-01 00:00:00
abstract::To identify the relevant CpG sites as molecular markers, for the diagnosis and to distinguish the indolent and aggressive prostate tumors, we have determined the methylation status of 8 genes, including FLNC, EFS, ECRG4, RARB2, PITX2, GSTP1, PDLIM4, and KCNMA1 in 32 nonrecurrent, 32 recurrent primary prostate tumors, ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802620794
更新日期:2009-06-01 00:00:00
abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024890
更新日期:1995-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903405918
更新日期:2010-10-01 00:00:00
abstract::Type-I insulin-like growth factor receptor (IGF1R) and its signaling play an important role in osteosarcomagenesis, tumor progression, and chemoresistance. The purpose of this study was to investigate both the effect and mechanisms of IGF1R inhibition by tyrphostin AG1024 in the presence or absence of doxorubicin in a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.606252
更新日期:2011-10-01 00:00:00
abstract::Until recently physicians have been reluctant to disclose a poor prognosis to patients for fear of harming them with the bad news and/or taking away their will to live. In the last decades we have seen a reversal of practice among Western physicians, and most doctors readily disclose to their patients the full extant ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900601063972
更新日期:2006-12-01 00:00:00
abstract::We have provided an overview of recent studies that have greatly expanded our knowledge of the molecular and cellular mechanisms that determine the sensitivity or resistance to ionizing radiation. Much of this knowledge was obtained by studying tumor and nontumor cell types that under- or overexpress proteins involved...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract::Effect of advanced glycation end products (AGEs) in the pathogenesis of cancer could be diminished by interaction with soluble RAGE or by reducing AGE-precursors via glyoxalase I. Glu111Ala polymorphism of glyoxalase I gene, AGEs, and sRAGE serum levels were studied in 113 breast cancer patients and in 58 controls. Hi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802350822
更新日期:2009-07-01 00:00:00
abstract::For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900701781812
更新日期:2008-06-01 00:00:00
abstract::As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-58819
更新日期:2005-01-01 00:00:00
abstract::CXCL12 is an extracellular chemokine binding to cell surface receptor CXCR4. We found that activation of CXCL12/CXCR4 axis stimulated angiogenesis in endothelial cells. Knockdown of CXCR4 in endothelial cells prevented the branch points of angiogenesis. Endothelial cells exposed to CXCL12 presented high level of epide...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1422512
更新日期:2018-01-02 00:00:00
abstract::Thirty patients with a diagnosis of metastatic adenocarcinoma of the lung were entered on a trial to evaluate the antitumor efficacy of 5-fluorouracil 370 mg/m2 daily for 5 days every four weeks in combination with folinic acid 200 mg/m2, 60 min prior to 5FU. All patients had a good performance status, bidimensionally...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357909009012052
更新日期:1990-01-01 00:00:00
abstract::The interaction of 5-fluorouracil and cyclophosphamide in the treatment of L1210 and P388 leukemias was studied using response surface methodology. Single dose treatment of each drug was administered simultaneously or with a 24-hr interval between 5-fluorouracil and cyclophosphamide to the advanced tumors or at variou...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908709020311
更新日期:1987-01-01 00:00:00
abstract::We observed that free bile acids (CA, DCA, and CDCA) inhibited the growth of cholangiocarcinoma cells by promoting cell apoptosis, while the conjugated bile acids (GCA, GDCA, and GCDCA) stimulated cell growth. Consistently, we found that GDCA stimulated tumor growth and CDCA decreased tumor growth in xenografted mice....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.762781
更新日期:2013-02-01 00:00:00
abstract::Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.697232
更新日期:2012-08-01 00:00:00
abstract::A number of studies have demonstrated the presence of mitochondrial DNA (mtDNA) mutations in cancer cells. In this article, we review mitochondrial genomic aberrations reported in solid tumors of the breast, colon, stomach, liver, kidney, bladder, head/neck, and lung. The tantalizing association of tumors with mtDNA m...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120002155
更新日期:2002-01-01 00:00:00
abstract::Statins (3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors), cholesterol-lowering agents widely prescribed for cardiovascular health, have been shown to exert several pleiotropic effects. Although some studies reported that statins have no effects on malignancies of any kind, results of several epidemiologic ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900802491444
更新日期:2009-05-01 00:00:00
abstract::The addition of corticosteroids in the early 1950s to the treatment armamentarium provided cure of some diseases and control of many. They have become an integral part of many cancer treatment regimens. Early reports of severe affective disorders appear less frequent today in patients receiving steroids, though contro...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357908909041378
更新日期:1989-01-01 00:00:00
abstract::Combination immune checkpoint inhibitors (ICIs) achieved higher efficacy than monotherapy in many types of cancers. We searched PubMed, Scopus, and Cochrane databases for randomized phase II/III trials in cancer patients receiving combination ICIs vs. Monotherapy. Our search retrieved 934 records. Eight studies were f...
journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
doi:10.1080/07357907.2020.1714053
更新日期:2020-03-01 00:00:00
abstract::Melanoma is an immunoresponsive malignancy. Interleukin-10 (IL-10) is a potent regulator of immunosuppression. The purpose of this research was to define the relationship of serum IL-10 to survival in patients with metastatic melanoma. Forty-one melanoma patients and 50 normal volunteers were analyzed. The median IL-1...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100102550
更新日期:2001-01-01 00:00:00
abstract::Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900601130763
更新日期:2007-02-01 00:00:00
abstract::Following is a review of altered fractionation in radiation therapy for head and neck cancer. The goals of altered fractionation are to increase local-regional control and/or reduce the risk of late complications. Altered fractionation schedules can be broadly classified as accelerated fractionation and hyperfractiona...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909809032890
更新日期:1998-01-01 00:00:00
abstract::This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.550663
更新日期:2011-03-01 00:00:00
abstract::This study compared the antiemetic efficacy and safety of two different intravenous (i.v.) dolasetron dosing regimens in patients receiving their first course of high-dose (> or = 80 mg/m2) cisplatin. Of 30 patients enrolled, 14 received a single i.v. dolasetron dose (0.6 mg/kg) before cisplatin and 16 received a mult...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.3109/07357909709039730
更新日期:1997-01-01 00:00:00
abstract::Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120016421
更新日期:2003-04-01 00:00:00
abstract::Neural stem cells (NSC) are capable of differentiating toward neuronal, astrocytic, oligodendrocytic and glial lineages, depending on their spatial location within the central nervous system (CNS). Although, a lot of knowledge has been gained in the understanding of differentiation-specific signaling in hematopoietic ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-200039679
更新日期:2004-01-01 00:00:00
abstract::The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908509040603
更新日期:1985-01-01 00:00:00