Disialoganglioside directed immunotherapy of neuroblastoma.

abstract：:One of the hallmarks of cancer is limitless proliferative capacity, which is tightly associated with the ability to maintain telomeres. Over the last decade, the telomere biology of pediatric cancers has begun to be elucidated. Most pediatric leukemias and embryonal solid tumors activate the enzyme telomerase, a speci...

journal_title：Cancer investigation

authors： Tabori U,Dome JS

更新日期：2007-04-01 00:00:00

abstract：:To further enhance anticancer effect of Shepherdin and overcome limitation of peptide therapy, recombinant adeno-associated virus (rAAV) was constructed with following strategies: therapeutic peptide secretory expression and adeno-associated virus gene transfer system. MTT assay and flow cytometric analysis revealed t...

journal_title：Cancer investigation

authors： Xiaojiang T,Jinsong Z,Jiansheng W,Chengen P,Guangxiao Y,Quanying W

更新日期：2010-06-01 00:00:00

abstract：:Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...

journal_title：Cancer investigation

authors： Ejaz S,Chekarova I,Ashraf M,Lim CW

更新日期：2006-10-01 00:00:00

abstract：:Withaferin A (WA) (1) and two analogs [4-epi-withaferin A (2) and 4,27-diacetyl-4-epi-withaferin A (3)] were evaluated for antitumor activity in pancreatic cancer cells. IC(50) for 1, 2, and 3 were 0.87, 0.45, and 0.29 ?M (BxPC-3); 1.28, 1.53, and 0.52 ?M (MIAPaCa-2); and 0.59, 2.25, and 0.56 ?M (PANC-1), respectively...

journal_title：Cancer investigation

authors： Liu X,Qi W,Cooke LS,Kithsiri Wijeratne EM,Xu YM,Marron MT,Leslie Gunatilaka AA,Mahadevan D

更新日期：2011-12-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...

journal_title：Cancer investigation

authors： Chiou JF,Lin MC,Chen DR,Jim YF,Kao CH

更新日期：2003-01-01 00:00:00

abstract：:N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...

journal_title：Cancer investigation

authors： Pergolizzi RG,Kreis W,Rottach C,Susin M,Broome JD

更新日期：1993-01-01 00:00:00

abstract：:Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...

journal_title：Cancer investigation

authors： Jasin M

更新日期：2000-01-01 00:00:00

abstract：:Interstitial collagenase-1 degrades a variety of extracellular matrix components. A single guanine insertion polymorphism in the promoter has been found that influences on the transcription and expression level of the gene. It is suggested that this polymorphism may enhance susceptibility to some types of cancer. Ther...

journal_title：Cancer investigation

authors： Kouhkan F,Motovali-Bashi M,Hojati Z

更新日期：2008-10-01 00:00:00

abstract：:Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cult...

journal_title：Cancer investigation

authors： Hao Y,Zhao Y,Zhao X,He C,Pang X,Wu TC,Califano JA,Gu X

更新日期：2011-05-01 00:00:00

abstract：:Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...

journal_title：Cancer investigation

authors： Frytak S,Lee RE,Pairolero PC,Arnold PG,Shaw JN

更新日期：1988-01-01 00:00:00

abstract：:This study is to evaluate the association between IL-8 -251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 -251A/T polymorphism was not associ...

journal_title：Cancer investigation

authors： Gao P,Zhao H,You J,Jing F,Hu Y

更新日期：2014-12-01 00:00:00

abstract：UNLABELLED:The effect of castration on the incorporation of [35S]methionine into secreted proteins in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors, was investigated. Biopsy specimens were obtained from 19 tumors, 0, 24, 48, 72, and 96 h after castration. In 14 tumors, castration induced an increase ...

journal_title：Cancer investigation

authors： Geier A,Hemi R,Beery R,Lunenfeld B

更新日期：1992-01-01 00:00:00

abstract：:The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for ...

journal_title：Cancer investigation

authors： Retsky MW,Swartzendruber DE,Bame PD,Wardwell RH

更新日期：1994-01-01 00:00:00

abstract：:Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...

journal_title：Cancer investigation

authors： Bierman HR,Faith MR,Stewart ME

更新日期：1988-01-01 00:00:00

abstract：:This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...

journal_title：Cancer investigation

authors： Zhao X,Liu J,Peng M,Liu J,Chen F

更新日期：2013-10-01 00:00:00

abstract：:The purpose of this study is to investigate whether hematopoiesis capacity, immunomodulatory effect and ex vivo expansion potential of mesenchymal stem cells (MSCs) are affected by cryopreservation. Chronic myeloid leukemia (CML) patients' bone marrow MSCs cryopreserved for 3 months, 6 months, and 1 year were thawed a...

journal_title：Cancer investigation

authors： Zhao ZG,Li WM,Chen ZC,You Y,Zou P

更新日期：2008-05-01 00:00:00

abstract：:Human papillomaviruses (HPVs) and BKV, JCV, and SV40 polyomaviruses (PYVs) are oncogenic viruses associated with different human tumors. Our aim was to determine if PYV and HPV sequences could be detected in human genital tumors. HPV types 6b, 11, 16, and 18 and PYV were investigated in 22 genital tumor samples and th...

journal_title：Cancer investigation

authors： Martini F,Iaccheri L,Martinelli M,Martinello R,Grandi E,Mollica G,Tognon M

更新日期：2004-01-01 00:00:00

abstract：:There are many changes in the immune response with age, most of which can be related to the involution of the thymus gland and alteration of the distribution and function of T lymphocytes. These changes indirectly influence B-cell function, which not only amplifies the immune deficits, but leads to the increased produ...

journal_title：Cancer investigation

authors： Ben-Yehuda A,Weksler ME

更新日期：1992-01-01 00:00:00

abstract：:Enthusiasms into the application of PI3K-δ inhibitor CAL-101 has been muted due to the over-activation of compensatory molecules. Our results delineated that c-Myc suppression using 10058-F4 enhanced CAL-101 cytotoxicity in less sensitive cells through different mechanisms based on p53 status; while CAL-101-plus-10058...

journal_title：Cancer investigation

authors： Riyahi N,Safaroghli-Azar A,Sheikh-Zeineddini N,Sayyadi M,Bashash D

更新日期：2019-01-01 00:00:00

abstract：:Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal ...

journal_title：Cancer investigation

authors： Orhan T,Nielsen PB,Hviid TVF,Rosen AW,Gögenür I

更新日期：2019-01-01 00:00:00

abstract：:CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...

journal_title：Cancer investigation

authors： Voigt H,Vetter-Kauczok CS,Schrama D,Hofmann UB,Becker JC,Houben R

更新日期：2009-03-01 00:00:00

abstract：:Doxorubicin and paclitaxel are highly active agents in the treatment of advanced breast cancer. Although early trials of the combination reported high response rates, an unexpectedly high incidence of congestive heart failure observed on two of the early trials was cause for much concern. More recently, clinical trial...

journal_title：Cancer investigation

authors： Perez EA

更新日期：2001-01-01 00:00:00

abstract：:Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...

journal_title：Cancer investigation

authors： Daugherty CK

更新日期：2004-01-01 00:00:00

abstract：:For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...

journal_title：Cancer investigation

authors： Tang SC

更新日期：2008-06-01 00:00:00

abstract：:Nature has provided many effective anticancer agents in current use, such as the microbially derived drugs; dactinomycin; bleomycin and doxorubicin; and the plant-derived drugs, vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents from natural sources continues through c...

journal_title：Cancer investigation

authors： Cragg GM,Newman DJ

更新日期：1999-01-01 00:00:00

abstract：:We studied the effects of Shikaron, which is composed of 8 Chinese herb extracts, on carcinogenesis and the cytotoxic activity and cytokine production of lymphocytes in mice treated with a carcinogen, N-butyl-N'-butanolnitrosoamine (BBN). We found a significantly lower incidence of urinary bladder carcinoma in mice tr...

journal_title：Cancer investigation

authors： Kurashige S,Jin R,Akuzawa Y,Endo F

更新日期：1998-01-01 00:00:00

abstract：:In this study, we investigated ALDH1A3, Mcl1, and miR-125a/b expression in HT29 cells and the effect of miR-125a/b on ALDH1A3 and Mcl1 expression. Our results showed that low expression of miR-125a/b and high expression of ALDH1A3 and Mel1 were observed in both ALDH1-positive HT29 and HT29-taxol cells. Overexpression ...

journal_title：Cancer investigation

authors： Chen J,Chen Y,Chen Z

更新日期：2013-01-01 00:00:00

abstract：:Transarterial radioembolization (TARE) is one of the therapeutic options for hepatocellular carcinoma (HCC). This study aimed to investigate the predictors and prognostic values of achieving curative treatments after TARE. Overall, 143 patients with intrahepatic HCC treated with TARE between 2011 and 2017 were recruit...

journal_title：Cancer investigation

authors： Kim Y,Lee HA,Lee JS,Jeon MY,Kim BK,Park JY,Kim DY,Ahn SH,Um SH,Seo YS,Kim SU

更新日期：2021-01-11 00:00:00

abstract：:Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...

journal_title：Cancer investigation

authors： Leonard JP,Siegel JA,Goldsmith SJ

更新日期：2003-04-01 00:00:00

abstract：:The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy...

journal_title：Cancer investigation

authors： Miteva L,Stanilov N,Deliysky T,Mintchev N,Stanilova S

更新日期：2009-11-01 00:00:00