Abstract:
BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from 2010-2012. RESULTS:Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of BrCA. Cases were more likely to have a morning (OR = 2.43, 95% CI = 1.23-4.81) or evening (OR = 2.55, 95% CI = 1.19-5.47) chronotype. CONCLUSIONS:Findings are consistent with the possibility that extremes in chronotype may elicit circadian desynchronization, resulting in increased BrCA susceptibility.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Wirth MD,Burch JB,Hébert JR,Kowtal P,Mehrotra-Kapoor A,Steck SE,Hurley TG,Gupta PC,Pednekar MS,Youngstedt SD,Zhang H,Sarin Rdoi
10.3109/07357907.2014.919305subject
Has Abstractpub_date
2014-08-01 00:00:00pages
321-9issue
7eissn
0735-7907issn
1532-4192journal_volume
32pub_type
杂志文章abstract::Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...
journal_title:Cancer investigation
pub_type: 杂志文章
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abstract::Reversible epidermal growth factor receptor tyrosine kinase inhibitors are often used for the treatment of non-small cell lung cancer following failure of cytotoxic chemotherapy. While these agents are active in a subset of patients, most develop resistance and progress within the course of 1 year. In nearly half of t...
journal_title:Cancer investigation
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abstract::The breast cancer treatment failure rate remains unacceptably high. The current breast cancer treatment paradigm, based primarily on Gompertzian kinetics and animal models, advocates short-course, intensive chemotherapy subsequent to tumor debulking, citing drug resistance and host toxicity as the primary reasons for ...
journal_title:Cancer investigation
pub_type: 杂志文章
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abstract::Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...
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abstract::The microvasculature is a ubiquitous organ system having a major role in the pathogenesis of radiation damage to normal tissues. Although the kinetics of radiation damage to endothelial cells is similar to other tissues (as reflected by Do and Dq) the late effect is a manifestation of injury, not only to the endotheli...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
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abstract::U-73,975 (U-73), U-77,779 (U-77), and U-80,244 (U-80) are analogs of the potent antitumor compound CC-1065. This class of drugs act as alkylating agents binding to DNA preferentially. Using the ATP-chemosensitivity assay, this study was designed to compare the potencies of U-73, U-77, and U-80 with cisplatin (DDP) or ...
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abstract:INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by ...
journal_title:Cancer investigation
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journal_title:Cancer investigation
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abstract:BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...
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pub_type: 杂志文章
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更新日期:2013-12-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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更新日期:1992-01-01 00:00:00
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journal_title:Cancer investigation
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更新日期:1995-01-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1080/07357900601130763
更新日期:2007-02-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2007-02-01 00:00:00
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pub_type: 杂志文章,评审
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pub_type: 杂志文章
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更新日期:2011-05-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2009-05-01 00:00:00
abstract::Expression of epidermal growth factor and its transmembrane receptor (EGFR) stimulates tumor growth. Matuzumab is a humanized anti-EGFR monoclonal antibody that blocks EGFR activation and downstream signaling, inhibits tumor growth, and provides a clinical benefit for some patients. The plasma half-life (6-10 days) an...
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pub_type: 杂志文章,评审
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
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journal_title:Cancer investigation
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
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abstract::Two groups of patients with disseminated breast carcinomas who had failed radiotherapy, chemotherapy, and hormonotherapy were treated with natural interferon alpha (nIFN-alpha) alone or in combination with nIFN-gamma delivered in cycles of 10-12 intralesional (i.l.) injections to recurrent and metastatic lesions. In g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
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更新日期:1995-01-01 00:00:00