Abstract:
:Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in plasma, using quantitative real-time polymerase chain reaction (PCR). The calculated area under the curve (AUC) of receiver operating characteristic (ROC) for cfcDNA was 0.875 (95% CI, 0.811-0.94), which was indicative of a high discriminatory power (p < 0.001) and significant accuracy in distinguishing cancer patients from healthy individuals. The quantification of cfcDNA could be useful for clinical settings of CRC.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Agah S,Akbari A,Talebi A,Masoudi M,Sarveazad A,Mirzaei A,Nazmi Fdoi
10.1080/07357907.2017.1408814subject
Has Abstractpub_date
2017-11-26 00:00:00pages
625-632issue
10eissn
0735-7907issn
1532-4192journal_volume
35pub_type
杂志文章abstract::Reversible epidermal growth factor receptor tyrosine kinase inhibitors are often used for the treatment of non-small cell lung cancer following failure of cytotoxic chemotherapy. While these agents are active in a subset of patients, most develop resistance and progress within the course of 1 year. In nearly half of t...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357901003631072
更新日期:2010-05-01 00:00:00
abstract::8-Chloro-cyclic-adenosine-3',5'-monophosphate (8-Cl-cAMP), a site-selective synthetic cyclic adenosine 3',5'-monophosphate (cAMP) analog exhibits growth inhibition in a broad spectrum of human cancer lines. However, detailed studies on the effects exerted by cAMP analogs on cell-cycle kinetics have been lacking. We ha...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120005913
更新日期:2002-01-01 00:00:00
abstract:BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-200026487
更新日期:2004-01-01 00:00:00
abstract::In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor ti...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.820318
更新日期:2013-08-01 00:00:00
abstract::Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909709039724
更新日期:1997-01-01 00:00:00
abstract::A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR:...
journal_title:Cancer investigation
pub_type: 杂志文章,meta分析
doi:10.1080/07357907.2019.1639057
更新日期:2019-01-01 00:00:00
abstract::Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900601130763
更新日期:2007-02-01 00:00:00
abstract::Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, an...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1309547
更新日期:2017-07-03 00:00:00
abstract::The aim of the current study was to determine the signaling differences between gamma- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or gamma-radiation. Proton beam was found to be more cytotoxic than gamma-radiation. Proton beam-irradiated cells showed phosphorylat...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003630991
更新日期:2010-07-01 00:00:00
abstract::The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1793352
更新日期:2020-08-01 00:00:00
abstract::Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077025
更新日期:1988-01-01 00:00:00
abstract::Placement of carmustine-impregnated wafers has become a common practice after surgical resection of malignant gliomas. Bevacizumab is used as a second-line agent for the treatment of malignant gliomas and is sometimes used in patients who have had recent wafer implantation. We describe two cases of fatal cerebrospinal...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2010.483499
更新日期:2010-12-01 00:00:00
abstract::The role of tyrosine kinase inhibitors (TKIs) in the treatment of advanced malignancies is well established. Imatinib and vatalanib are oral TKIs with different mechanisms of action. This trial sought to establish the safety, tolerability, and maximum tolerated dose (MTD) of the two agents in combination. Secondary ob...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2011.568567
更新日期:2011-05-01 00:00:00
abstract::ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2014.964409
更新日期:2014-12-01 00:00:00
abstract::This study showed that silencing BMP4 expression significantly activated caspase-2, 3, and 9, while decreasing Matrigel colony formation in Cytarabine (Ara-C)-treated leukemia HL-60 cells. In contrast, Ara-C significantly upregulated Atg5 and Beclin-1 expression, the ratio of LC3-II/LC3-I, and CDK1 and cyclin B1 expre...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.834925
更新日期:2013-10-01 00:00:00
abstract::Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100106144
更新日期:2001-01-01 00:00:00
abstract::In conclusion, the prognosis for women with stage I borderline tumors is excellent. Surgery alone is the recommended treatment. For young patients, fertility-sparing surgery is optimal, with a small percentage eventually developing tumor in the contralateral ovary. For patients with advanced stage borderline tumors, 1...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909909021423
更新日期:1999-01-01 00:00:00
abstract::A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.700986
更新日期:2013-05-01 00:00:00
abstract::An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908609017510
更新日期:1986-01-01 00:00:00
abstract::Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357900009031826
更新日期:2000-01-01 00:00:00
abstract::Twenty-two patients with disseminated adenocarcinoma of the large bowel received therapy with 5-fluorouracil 800-1000 mg/m2 as a 24 h infusion for 4 consecutive days with 60 mg/m2 intravenous folinic acid administered every 6 hours. Major responses were seen in 3 of 20 (15%) evaluable patients, for a median of 5 month...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077039
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abstract::Until recently physicians have been reluctant to disclose a poor prognosis to patients for fear of harming them with the bad news and/or taking away their will to live. In the last decades we have seen a reversal of practice among Western physicians, and most doctors readily disclose to their patients the full extant ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900601063972
更新日期:2006-12-01 00:00:00
abstract::Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.732164
更新日期:2012-12-01 00:00:00
abstract::A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849657
更新日期:2009-10-01 00:00:00
abstract::The scientific rationale to block angiogenesis as a treatment strategy for human cancer has been developed over the last 30 years, but is only now entering the clinical arena. Preclinical studies have demonstrated the importance of the vascular endothelial growth factor (VEGF) pathways in both physiologic and patholog...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500360024
更新日期:2005-01-01 00:00:00
abstract::Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.681821
更新日期:2012-07-01 00:00:00
abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024890
更新日期:1995-01-01 00:00:00
abstract::We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309011669
更新日期:1993-01-01 00:00:00
abstract::UFT is the combination of the fluorouracil (5-FU) prodrug tegafur, and the dihydrophyrimidine dehydrogenase inhibitor uracil. UFT and leucovorin have been used in the oral treatment of a variety of malignancies. Given the radiosensitizing properties of UFT, its combination with radiation therapy is a logical step in t...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120022382
更新日期:2003-01-01 00:00:00
abstract::Nature has provided many effective anticancer agents in current use, such as the microbially derived drugs; dactinomycin; bleomycin and doxorubicin; and the plant-derived drugs, vinblastine, irinotecan, topotecan, etoposide, and paclitaxel. The search for novel antitumor agents from natural sources continues through c...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00