Abstract:
:Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies (experimental pathology, immunology and molecular biology, synergism, selectivity and safety), in vitro biochemical studies, and human studies (epidemiology and biomarkers, prevention of many pathologic entities other than cancer).
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Shklar G,Oh SKdoi
10.3109/07357900009031826subject
Has Abstractpub_date
2000-01-01 00:00:00pages
214-22issue
3eissn
0735-7907issn
1532-4192journal_volume
18pub_type
杂志文章,评审abstract::We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802570759
更新日期:2009-02-01 00:00:00
abstract::Esophageal cancer is multifactorial disease involving environmental and genetic risk factors. Tobacco smoke and alcohol are strong environmental risk factors. N-acetyltransferase 2 (NAT2) is known to metabolize heterocyclic amine carcinogens in tobacco smoke. The purpose of this study was to determine whether genetic ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701358074
更新日期:2007-08-01 00:00:00
abstract::Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357900009023065
更新日期:2000-01-01 00:00:00
abstract::One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved loc...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.1001898
更新日期:2015-04-01 00:00:00
abstract:BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120000360
更新日期:2002-01-01 00:00:00
abstract::The study investigated the human cytomegalovirus (HCMV) and human papillomavirus (HPV) in gliomas. A retrospective study was conducted on 112 samples. HCMV was investigated by PCR, in situ hybridization (ISH) and immunohistochemistry. HPV was tested by PCR and DNA ISH. HCMV was identified in 60 gliomas, including 55 G...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1793352
更新日期:2020-08-01 00:00:00
abstract::Multifractionated dosing (MFD) schedules for chemotherapy administration such as weekly or twice weekly administration are intended to maximize dose intensity while minimizing toxicity, but the cumulative drug effect may result in neutropenia necessitating interruption of dose fractions and thereby compromising dose i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909909032865
更新日期:1999-01-01 00:00:00
abstract::U-73,975 (U-73), U-77,779 (U-77), and U-80,244 (U-80) are analogs of the potent antitumor compound CC-1065. This class of drugs act as alkylating agents binding to DNA preferentially. Using the ATP-chemosensitivity assay, this study was designed to compare the potencies of U-73, U-77, and U-80 with cisplatin (DDP) or ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309024852
更新日期:1993-01-01 00:00:00
abstract::Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:
更新日期:2005-01-01 00:00:00
abstract::This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2010.550663
更新日期:2011-03-01 00:00:00
abstract::The interleukin-2 (IL2) gene is assigned to human chromosome 4. A synthetic oligonucleotide representing bases 285 to 324 of the IL2 cDNA clone described by Taniguchi et al. [Nature (London) 302:305-310, 1983] was used as hybridization probe in Southern blots. Eco RI digests of DNA derived from 11 somatic mouse-human ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908409018440
更新日期:1984-01-01 00:00:00
abstract:PURPOSE:Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532, an inhibitor of telomerase on chondrosarcoma cells in vitro. METHODS:Telomerase activity, telomere lengths, growth kinetics and chemosensitivity were analyzed in...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802072905
更新日期:2008-07-01 00:00:00
abstract::Mucositis is a common and often serious acute morbidity when radiation is delivered to portals encompassing the oral cavity, pharynx, or esophagus. In an effort to minimize this side effect, the combination of sucralfate and fluconazole was prescribed to 40 patients. Half were given sucralfate, 1 g in suspension q.i.d...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909509024890
更新日期:1995-01-01 00:00:00
abstract::Based on a preliminary trial that suggested that CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and PVB (cisplatinum, vinblastine, bleomycin), are at least partially non-cross-resistant, the Southwest Oncology Group treated patients with unfavorable histology, non-Hodgkin's lymphoma with CHOP and PVB. ...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357909109039872
更新日期:1991-01-01 00:00:00
abstract::A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1453072
更新日期:2018-03-16 00:00:00
abstract::Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-120027587
更新日期:2004-01-01 00:00:00
abstract::Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077025
更新日期:1988-01-01 00:00:00
abstract::Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2018.1453933
更新日期:2018-04-21 00:00:00
abstract:BACKGROUND:A 96-hour infusion schedule of paclitaxel demonstrates tolerability and antitumor activity in lung cancer and breast cancer refractory to short-duration infusion paclitaxel. Given the activity of paclitaxel in esophageal cancer, a phase II trial of 96-hour infusion paclitaxel in esophageal cancer was underta...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120022360
更新日期:2003-01-01 00:00:00
abstract::Soft tissue sarcomas are generally resistant to most chemotherapeutic agents, and individuals with advanced disease have a poor prognosis. We evaluated amonafide, a new drug that has significant activity against several tumor cell lines, to determine its activity against sarcomas. Amonafide was administered to 18 pati...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357909409038230
更新日期:1994-01-01 00:00:00
abstract::We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.861470
更新日期:2014-01-01 00:00:00
abstract::Lung cancer is the leading cause of cancer death worldwide and small cell lung cancer (SCLC) accounts for a significant proportion of all lung cancer cases. Even so, the underlying mechanism governing SCLC development remains poorly understood and SCLC related cancer death stands high despite decades of intensive inve...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2015.1006329
更新日期:2015-04-01 00:00:00
abstract::Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoke...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909909032874
更新日期:1999-01-01 00:00:00
abstract::CXCL12 is an extracellular chemokine binding to cell surface receptor CXCR4. We found that activation of CXCL12/CXCR4 axis stimulated angiogenesis in endothelial cells. Knockdown of CXCR4 in endothelial cells prevented the branch points of angiogenesis. Endothelial cells exposed to CXCL12 presented high level of epide...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1422512
更新日期:2018-01-02 00:00:00
abstract::Adriamycin (ADM, or doxorubicin hydrochloride) is an effective antineoplastic agent whose use is restricted by its well-described, dose-dependent cardiotoxicity. This study measures ADM DNA adduct formation by 32P-radiolabeling DNA, enzymatically digesting radiolabeled DNA, separating the formed adducts on two-dimensi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120016404
更新日期:2003-01-01 00:00:00
abstract::The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908509040603
更新日期:1985-01-01 00:00:00
abstract:INTRODUCTION:The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. METHODS:One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. RESULTS:The median normal MnSOD expression...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900903405918
更新日期:2010-10-01 00:00:00
abstract::Macrophages in malignant pleural effusions (MPEs) demonstrate a promalignant phenotype. They release mediators, which are a source of inflammation within the pleura. We established in vitro model proving that pleural macrophages isolated from effusions affect cancer cells in their pro- or anti-apoptotic activity via h...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2018.1477158
更新日期:2018-01-01 00:00:00
abstract::We analyzed the pattern of alpha-fetoprotein (AFP) synthesis in 40 consecutive human hepatocarcinomas (HCC) in relation to hepatitis B viral (HBV) infection. In addition, histopathological characteristics of liver parenchyma and the tumor itself were examined. Elevated AFP (> 20 ng/ml) were found in 90% of HCC patient...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909209024813
更新日期:1992-01-01 00:00:00
abstract::The vinca alkaloids represent one of the oldest classes of antineoplastic agents used in humans with a wide spectrum of activity against both animal and human tumors. These agents are known to inhibit microtubule polymerization. Vinorelbine is a semisynthetic analog that reached clinical trial on the basis of less pre...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909709047587
更新日期:1997-01-01 00:00:00