Abstract:
:Standard chemotherapeutic regimens, such as cisplatin and etoposide, may improve quality of life and prolong survival in patients with incurable non-small cell lung cancer (NSCLC). This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stage NSCLC: mitomycin C, etoposide, and cisplatin (MEP). Sixty-eight patients with stage IIIB (pleural effusion) or IV NSCLC received cisplatin 80 mg/m2 i.v. on day 1 and etoposide 80 mg/m2 i.v. on days 1, 2, and 3 every 3 weeks along with mitomycin C 10 mg/m2 i.v. on day 1 of the first and third cycles for a median of four cycles (range, 1-11). Median age was 59 years, and nine patients were enrolled after relapse from previously treated early-stage NSCLC. Eighty-eight percent of patients had stage IV disease, and 14 (21%) had brain metastases at diagnosis. Palliative radiotherapy was given to 10 patients (15%) before MEP and to 17 (25%) concurrent with MEP. The major toxicity of MEP was myelosuppression, with grade 3-4 neutropenia in 74% of patients. Sixteen patients (24%) had documented infections, and there were eight (12%) treatment-related deaths. Partial response was observed in 24 patients (35%) with a median duration of 4.4 months, (range 1.4-13 months). Median survival was 8.1 months (range, 1-34 months), and 1-year survival was 32%. The addition of mitomycin C to cisplatin and etoposide resulted in response and survival rates comparable with those achieved with standard regimens in patients with advanced NSCLC but was associated with substantial hematologic toxicity and unacceptable treatment-related mortality.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Ali MA,Kraut MJ,Valdivieso M,Wozniak AJ,Cummings G,Kalemkerian GPdoi
10.3109/07357900009023055subject
Has Abstractpub_date
2000-01-01 00:00:00pages
1-5issue
1eissn
0735-7907issn
1532-4192journal_volume
18pub_type
临床试验,杂志文章,多中心研究abstract::Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900601130763
更新日期:2007-02-01 00:00:00
abstract::The sequential administration of standard chemotherapy regimens to treat metastatic breast cancer may keep patients and oncologists from considering other important, but more psychologically difficult, issues such as the patient's declining health or approaching death. This practice also utilizes health care resources...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409021402
更新日期:1994-01-01 00:00:00
abstract::N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909309020257
更新日期:1993-01-01 00:00:00
abstract::Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701518487
更新日期:2007-10-01 00:00:00
abstract::Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039842
更新日期:1989-01-01 00:00:00
abstract::Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900600814847
更新日期:2006-08-01 00:00:00
abstract::We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to b...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802563010
更新日期:2009-07-01 00:00:00
abstract::Requirements for the induction of anomalous killer (AK) cells to syngeneic MOPC 104E-KI81 plasmacytoma, and their pattern of reaction were investigated. The AK cells are Thy-1.2 positive and were induced by cocultivation of normal BALB/c spleen cells for 5 days in vitro with mitomycin C-treated MOPC 104E-KI81 cells in...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909038265
更新日期:1989-01-01 00:00:00
abstract:BACKGROUND:We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors. METHODS:From January 1998 to November 1999, we treated 28 patients on a phase I protocol with gemcitabine given at a constant dose of 800 mg/m2 i.v. ov...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120018225
更新日期:2003-06-01 00:00:00
abstract::Tumor-infiltrating leukocytes and other immunohistochemical parameters were evaluated in pretherapeutic biopsies and resection specimens in 73 patients undergoing neoadjuvant chemotherapy with doxorubicin and paclitaxel. Ten patients with pathological complete response had significantly higher p53 expression, CD3(+) l...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802098165
更新日期:2008-12-01 00:00:00
abstract::Cancer is a proficient evader of the immune system and is responsible for a high number of deaths annually. Most of these cancer cases are associated with genetic mutations, viruses, radiations or other carcinogenic substances like tobacco smoke. However, a significant number of cases arise as a result of infection by...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2019.1662918
更新日期:2019-01-01 00:00:00
abstract::Arsenic trioxide is valuable for treatment of promyelocytic leukemia, but less attention has been paid to its therapeutic potential for other cancers. In this study, the effects of arsenic trioxide were tested in human pancreatic (AsPC-1), colonic (HT-29), and breast (MCF-7) cancer cells. In all three cancer cell line...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-200029068
更新日期:2004-01-01 00:00:00
abstract::Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adu...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2012.654872
更新日期:2012-03-01 00:00:00
abstract::8-Chloro-cyclic-adenosine-3',5'-monophosphate (8-Cl-cAMP), a site-selective synthetic cyclic adenosine 3',5'-monophosphate (cAMP) analog exhibits growth inhibition in a broad spectrum of human cancer lines. However, detailed studies on the effects exerted by cAMP analogs on cell-cycle kinetics have been lacking. We ha...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120005913
更新日期:2002-01-01 00:00:00
abstract::In vivo and in vitro observations of cellular immune response in 70 patients with squamous cell cancer of the oral cavity and in 40 age-matched normal controls, were made using delayed hypersensitivity responses to DNCB, PPD, and Candida albicans extract (Dermatophytin 'O'), absolute lymphocyte counts, absolute T-cell...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908609018450
更新日期:1986-01-01 00:00:00
abstract::The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701840212
更新日期:2008-08-01 00:00:00
abstract::Several studies have shown that sera from patients with Hodgkin's disease contain factors capable of inhibiting polymorphonuclear functions, among them chemotaxis. In the present study, we investigated whether these sera, which were able to inhibit PMN chemotaxis in the agarose test, were also able to affect the 3H-NE...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909409024868
更新日期:1994-01-01 00:00:00
abstract::A 69-year-old man receiving monotherapy for lung cancer with dichloromethotrexate (DCM), and without exposure to other chemotherapeutic agents or known ototoxic drugs, developed profound cochleovestibular dysfunction. The initial presentation was vestibular. This resolved, but unilateral hearing loss ensued and contin...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908909039861
更新日期:1989-01-01 00:00:00
abstract::After nearly decades of extinction as a sedative and antiemetic, thalidomide reemerged as the parent compound of a novel and promising class of therapeutics termed the immunomodulatory drugs (IMiDs). The analogues of thalidomide, CC-5013 (lenalidomide, Revlimid) and CC-4047 (Actimid) are more potent regulators of cell...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357900500283101
更新日期:2005-01-01 00:00:00
abstract::A case control study was undertaken to investigate the association of polymorphisms in cytochrome P4501A1 (CYP1A1) with squamous cell carcinoma of head and neck (HNSCC) in North Indian population. The variant genotypes of CYP1A1*2A and CYP1A1*2C were found to be overrepresented in cases when compared to controls. The ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900902849657
更新日期:2009-10-01 00:00:00
abstract::The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908509040603
更新日期:1985-01-01 00:00:00
abstract::This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900902744494
更新日期:2010-03-01 00:00:00
abstract::Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077041
更新日期:1988-01-01 00:00:00
abstract::Fibronectin (Fn) synergizes with macrophages (M phi) in inducing cytostasis and cytotoxicity of neoplastic cells in culture. Since heparin enhances Fn's opsonic activity in many systems, we investigated its effect on Fn-macrophage synergy in cytostasis. MCG-T14 (a spontaneous mouse mammary adenocarcinoma) cells (4 X 1...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908409040310
更新日期:1984-01-01 00:00:00
abstract:UNLABELLED:The effect of castration on the incorporation of [35S]methionine into secreted proteins in 7,12-dimethylbenz(a)anthracene (DMBA)-induced rat mammary tumors, was investigated. Biopsy specimens were obtained from 19 tumors, 0, 24, 48, 72, and 96 h after castration. In 14 tumors, castration induced an increase ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909209032762
更新日期:1992-01-01 00:00:00
abstract::The aim of our study was to investigate the role of nerve growth factor (NGF) on the expression of the p73 protein in human ependymoblastoma (EP) and medulloblastoma (MB) cells. It was found that NGF exposure on MB cells blocks proliferation, as well as on EP cells and induces overexpression of p73. NGF reduces the nu...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701205689
更新日期:2007-03-01 00:00:00
abstract::Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoke...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909909032874
更新日期:1999-01-01 00:00:00
abstract::Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b i...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2016.1242010
更新日期:2016-11-25 00:00:00
abstract::Increasing evidence indicates that disruption of circadian rhythms may be directly linked to cancer. Here we report that the expression levels of the core clock genes Per1 and Per3 measured by droplet digital polymerase chain reaction are significantly decreased in tumour tissue from 16 patients undergoing colorectal ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1571079
更新日期:2019-01-01 00:00:00
abstract::Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated wi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2020.1852411
更新日期:2021-01-01 00:00:00