Immunoregulation of murine plasmacytoma. II. Target selectivity of anomalous killer cells and role of immune T cells for the induction.

abstract：:Methylation pattern is presented here for first time as a potential molecular marker of changes on SSTR2A and SHP-1(I) gene promoter related to breast and prostate carcinoma. Our results have shown low concordances with SSTR2A and methylated state in prostate cancer and moderate relationship with unmethylated CpG-27 i...

journal_title：Cancer investigation

authors： Tiscornia MM,González HS,Lorenzati MA,Zapata PD

更新日期：2015-03-01 00:00:00

abstract：:Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...

journal_title：Cancer investigation

authors： Bierman HR,Faith MR,Stewart ME

更新日期：1988-01-01 00:00:00

abstract：:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...

journal_title：Cancer investigation

authors： Schattner EJ

更新日期：2002-01-01 00:00:00

abstract：:Seven patients developed a lung abscess and bronchopleural fistula after undergoing aggressive treatment of their lung cancer with radiotherapy +/- chemotherapy. These complications were preceded by a prodrome of recurrent bronchitis with increasing refractoriness to antibiotics, weight loss, fever, and generalized de...

journal_title：Cancer investigation

authors： Frytak S,Lee RE,Pairolero PC,Arnold PG,Shaw JN

更新日期：1988-01-01 00:00:00

abstract：:Like many tumor suppressor genes, some miRNA genes harboring CpG islands undergo methylation-mediated silencing. In the study, we found significant downregulation and proximal promoter methylation of miR-203a and miR-203b in gastric cardia adenocarcinoma (GCA) tissues. The methylation status of miR-203a and miR-203b i...

journal_title：Cancer investigation

authors： Liu W,Dong Z,Liang J,Guo X,Guo Y,Shen S,Kuang G,Guo W

更新日期：2016-11-25 00:00:00

abstract：:The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed ...

journal_title：Cancer investigation

authors： Viñolas N,Garrido P,Isla D,Provencio M,Majem M,Artal A,Carcereny E,Garcia Campelo R,Lianes P,De La Peñas R,Felip E

更新日期：2017-05-28 00:00:00

abstract：:Hand-Foot Syndrome (HFS) is commonly reported in treatment with liposomal doxorubicin (LD) and capecitabine. We present 3 cases of HFS recall with gefitinib after previous LD therapy. The first 2 cases, in patients with head and neck cancer previously treated with paclitaxel and LD, developed on subsequent therapy wit...

journal_title：Cancer investigation

authors： Razis E,Karina M,Karanastassi S,Fountzilas G

更新日期：2006-08-01 00:00:00

abstract：:We analyzed the pattern of alpha-fetoprotein (AFP) synthesis in 40 consecutive human hepatocarcinomas (HCC) in relation to hepatitis B viral (HBV) infection. In addition, histopathological characteristics of liver parenchyma and the tumor itself were examined. Elevated AFP (> 20 ng/ml) were found in 90% of HCC patient...

journal_title：Cancer investigation

authors： Kashala LO,Kalengayi MM,Essex M

更新日期：1992-01-01 00:00:00

abstract：:The interaction of 5-fluorouracil and cyclophosphamide in the treatment of L1210 and P388 leukemias was studied using response surface methodology. Single dose treatment of each drug was administered simultaneously or with a 24-hr interval between 5-fluorouracil and cyclophosphamide to the advanced tumors or at variou...

journal_title：Cancer investigation

authors： Wampler GL,Carter WH Jr,Campbell ED

更新日期：1987-01-01 00:00:00

abstract：:Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...

journal_title：Cancer investigation

authors： Ejaz S,Chekarova I,Ashraf M,Lim CW

更新日期：2006-10-01 00:00:00

abstract：:We carried out a phase I trial with chlorambucil. Thirty patients with advanced cancer were entered in six dose levels: 36, 48, 60, 84, 108, and 144 mg/m2. The drug was given in six divided oral doses every 6 hours and the regimen was repeated every 3 weeks. The median age was 62 years (31-84), median Karnofsky perfor...

journal_title：Cancer investigation

authors： Blumenreich MS,Woodcock TM,Sherrill EJ,Richman SP,Gentile PS,Epremian BE,Kubota TT,Allegra JC

更新日期：1988-01-01 00:00:00

abstract：:Despite the dramatic success achieved over the past few years in improving the survival of individuals with cancer, treatment for many patients with advanced malignancies remains far from satisfactory. Unfortunately, centers engaged in clinical cancer research are currently faced with the dilemma of dealing with incre...

journal_title：Cancer investigation

authors： Markman M

更新日期：1987-01-01 00:00:00

abstract：:Twenty four patients with epithelial ovarian cancer, who were treated by chemotherapy after debulking surgery, were monitored by serial monthly CA125 estimation and half-yearly computerized axial tomogram (CAT) of abdomen and pelvis. The efficiency of these monitoring methods and that of clinical examination were comp...

journal_title：Cancer investigation

authors： Ngan HY,Wong LC,Chan SY,Ma HK

更新日期：1990-01-01 00:00:00

abstract：:Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated wi...

journal_title：Cancer investigation

authors： Yang Z,Ma J,Qi G,Zhang X

更新日期：2021-01-01 00:00:00

abstract：:Drug resistance to TKIs and the existance of CML leukemia stem cells is an urgent problem. In this study, we demonstrate that quinacrine (QC) induces apoptosis in BCR-ABL positive CML and acute lymphoblastic leukemia (ALL) cells. Interestingly, QC inhibits the colony formation of primary CD34+ progenitor/stem leukemia...

journal_title：Cancer investigation

authors： Lei H,Tu Y,Yang L,Jin J,Luo H,Xu H,Kang J,Zhou L,Wu Y

更新日期：2019-01-01 00:00:00

abstract：:Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...

journal_title：Cancer investigation

authors： Shigetomi H,Tsunemi T,Haruta S,Kajihara H,Yoshizawa Y,Tanase Y,Furukawa N,Yoshida S,Sado T,Kobayashi H

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:We conducted a phase I study to determine the maximum tolerated dose of docetaxel in combination with gemcitabine for patients with refractory solid tumors. METHODS:From January 1998 to November 1999, we treated 28 patients on a phase I protocol with gemcitabine given at a constant dose of 800 mg/m2 i.v. ov...

journal_title：Cancer investigation

authors： Poole ME,Bernard SA,Churchel MA,Weissler MC,Calvo B,Cance W,Ollila D,Koruda M,Behrns K,Detterbeck FC

更新日期：2003-06-01 00:00:00

abstract：:Computer visualization techniques (CVTs) are an emerging technology that can organize all cancer specialists. This article describes CVTs' ability to maximize the currently untapped advantages of intensity modulated radiotherapy (IMRT). The visual speed and dynamic strategies inherent in CVTs improves IMRT by distilli...

journal_title：Cancer investigation

authors： Butler EB,Shukla V,Paulino AC,Lu HH,Butler R,Smiedala M,Kurk J,Grant WH 3rd,McGary JE,Teh BS

更新日期：2007-02-01 00:00:00

abstract：:Neural stem cells (NSC) are capable of differentiating toward neuronal, astrocytic, oligodendrocytic and glial lineages, depending on their spatial location within the central nervous system (CNS). Although, a lot of knowledge has been gained in the understanding of differentiation-specific signaling in hematopoietic ...

journal_title：Cancer investigation

authors： Mondal D,Pradhan L,LaRussa VF

更新日期：2004-01-01 00:00:00

abstract：:Autologous bone marrow transplantation (AuBMT) is an accepted treatment modality for patients with high-risk or relapsed hematological malignancies. Hepatotoxicity, in particular veno-occlusive disease (VOD), is a significant complication of this therapy. The purpose of this study was to determine the clinical relevan...

journal_title：Cancer investigation

authors： Wasserheit C,Acaba L,Gulati S

更新日期：1995-01-01 00:00:00

abstract：:The host immune response can impact cancer growth, prognosis, and response to therapy. In colorectal cancer, the presence of cells involved with T-cell-mediated adaptive immunity predicts survival better than the current staging method. We used the expression of genes recently associated with host immune responses (T(...

journal_title：Cancer investigation

authors： Hsu DS,Kim MK,Balakumaran BS,Acharya CR,Anders CK,Clay T,Lyerly HK,Drake CG,Morse MA,Febbo PG

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND:This study examined a PERIOD3 (PER3) gene variable number tandem repeat polymorphism and chronotype as potential BrCA risk factors among Indian women. METHODS:This case-control study included sporadic, histologically confirmed BrCA cases (n = 255) and controls (n = 249) from India with data collection from ...

journal_title：Cancer investigation

authors： Wirth MD,Burch JB,Hébert JR,Kowtal P,Mehrotra-Kapoor A,Steck SE,Hurley TG,Gupta PC,Pednekar MS,Youngstedt SD,Zhang H,Sarin R

更新日期：2014-08-01 00:00:00

abstract：:Recent clinical trials have demonstrated the significant cancer preventive potential of vitamin E in many different cancer sites, ranging from oral and pharyngeal cancer to prostate cancer. There is an extensive experimental basis for this clinical cancer inhibition. The experimental background includes animal studies...

journal_title：Cancer investigation

authors： Shklar G,Oh SK

更新日期：2000-01-01 00:00:00

abstract：:Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...

journal_title：Cancer investigation

authors： Akhtar-Danesh N,Akhtar-Danseh GG,Seow HY,Shakeel S,Finley C

更新日期：2019-01-01 00:00:00

abstract：:Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...

journal_title：Cancer investigation

authors： Armer JM

更新日期：2005-01-01 00:00:00

abstract：:Malignant kidney tumors account for approximately 2% of all new primary cancer cases diagnosed in the United States, with an estimated 30,000 cases occurring annually. Although a variety of agents, chemical and biological, have been implicated as causal agents in the development of renal cell carcinoma (RCC), the etio...

journal_title：Cancer investigation

authors： Moore LE,Wilson RT,Campleman SL

更新日期：2005-01-01 00:00:00

abstract：:Fibronectin (Fn) synergizes with macrophages (M phi) in inducing cytostasis and cytotoxicity of neoplastic cells in culture. Since heparin enhances Fn's opsonic activity in many systems, we investigated its effect on Fn-macrophage synergy in cytostasis. MCG-T14 (a spontaneous mouse mammary adenocarcinoma) cells (4 X 1...

journal_title：Cancer investigation

authors： Martin DE,Reece M,Reese AC

更新日期：1984-01-01 00:00:00

abstract：:The complex formed by isopentane, as a model for the isoleucine residue present in the wild-type thymidylate synthase, with 4-mercaptopyridine as a fragment of the thymidylate synthase inhibitor Thymitaq (AG337) is investigated with ab initio quantum chemical calculations at Hartree-Fock and MP2 levels, using the 3-21...

journal_title：Cancer investigation

authors： Sapse DS,Tong Y,Bertino JR,Sapse AM

更新日期：1999-01-01 00:00:00

abstract：:Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inherita...

journal_title：Cancer investigation

authors： Foroud T

更新日期：1997-01-01 00:00:00

abstract：:The role of tyrosine kinase inhibitors (TKIs) in the treatment of advanced malignancies is well established. Imatinib and vatalanib are oral TKIs with different mechanisms of action. This trial sought to establish the safety, tolerability, and maximum tolerated dose (MTD) of the two agents in combination. Secondary ob...

journal_title：Cancer investigation

authors： Spigel D,Jones S,Hainsworth J,Infante J,Greco FA,Thompson D,Doss H,Burris H

更新日期：2011-05-01 00:00:00