Targeting Glioma Stem Cells by Functional Inhibition of Dynamin 2: A Novel Treatment Strategy for Glioblastoma.

abstract：:Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...

journal_title：Cancer investigation

authors： Gazitt Y,Gurfel D,Leizerowitz R,Feinstein H,Polliack A

更新日期：1987-01-01 00:00:00

abstract：:Venous thromboembolic disease is a major cause of morbidity in cancer patients. The Perspective database was used to identify patients with solid tumors and a diagnosis of VTE from 2006 to 2012. We examined use of IVC filters, thrombolysis, and thrombectomy. Among 32,545 patients, 23.1% received an IVC filter, 1.9% th...

journal_title：Cancer investigation

authors： Yoon L,Clarke Hillyer G,Chen L,Hu JC,Neugut AI,Hershman DL,Wright JD

更新日期：2016-09-13 00:00:00

abstract：:Pancreatic cancer is the fourth leading cause of cancer death with a 5-year survival less than 5 percent despite rigorous interventions. This largely is due to its late presentation, aggressive metastasis, and a lack of effective adjuvant therapies. Cytokines have been studied in many tumor types, where they have been...

journal_title：Cancer investigation

authors： Feurino LW,Fisher WE,Bharadwaj U,Yao Q,Chen C,Li M

更新日期：2006-11-01 00:00:00

abstract：:Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...

journal_title：Cancer investigation

authors： Amirghofran Z,Bahmani M,Azadmehr A,Ashouri E,Javidnia K

更新日期：2007-10-01 00:00:00

abstract：:The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used wa...

journal_title：Cancer investigation

authors： Kolotas C,Daniel M,Demetriou L,Martin T,Kurek R,Tonus C,Göbel U,Schnabel T,Zamboglou N

更新日期：2001-01-01 00:00:00

abstract：:Human papillomaviruses (HPVs) and BKV, JCV, and SV40 polyomaviruses (PYVs) are oncogenic viruses associated with different human tumors. Our aim was to determine if PYV and HPV sequences could be detected in human genital tumors. HPV types 6b, 11, 16, and 18 and PYV were investigated in 22 genital tumor samples and th...

journal_title：Cancer investigation

authors： Martini F,Iaccheri L,Martinelli M,Martinello R,Grandi E,Mollica G,Tognon M

更新日期：2004-01-01 00:00:00

abstract：:This study combined infusional mitoxantrone with bolus melphalan as a transplant preparative regimen for multiple myeloma. Mitoxantrone was infused over 6 hr on days 6 and 5. Melphalan was given as a 15 min bolus on day 1 followed by autologous transplant on day 0. Thirty-five patients were enrolled; 57% of enrollees ...

journal_title：Cancer investigation

authors： Beaven AW,Moore DT,Sharf A,Serody JS,Shea TC,Gabriel DA

更新日期：2011-03-01 00:00:00

abstract：:ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...

journal_title：Cancer investigation

authors： Wang H,Yang Q,Fu Z,Zuo D,Hua Y,Cai Z

更新日期：2014-12-01 00:00:00

abstract：:The vinca alkaloids represent one of the oldest classes of antineoplastic agents used in humans with a wide spectrum of activity against both animal and human tumors. These agents are known to inhibit microtubule polymerization. Vinorelbine is a semisynthetic analog that reached clinical trial on the basis of less pre...

journal_title：Cancer investigation

authors： Budman DR

更新日期：1997-01-01 00:00:00

abstract：:We hypothesized that co-targeting the epidermal growth factor receptor (EGFR) and Src with the EGFR inhibitor gefitinib and the Src inhibitor AZD0530 would increase growth inhibition and impede migration. Cells overexpressing EGFR were more sensitive to gefitinib than cells expressing mutated EGFR or normal levels of ...

journal_title：Cancer investigation

authors： Andersen P,Villingshøj M,Poulsen HS,Stockhausen MT

更新日期：2009-02-01 00:00:00

abstract：:A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...

journal_title：Cancer investigation

authors： Scherbakov AM,Borunov AM,Buravchenko GI,Andreeva OE,Kudryavtsev IA,Dezhenkova LG,Shchekotikhin AE

更新日期：2018-03-16 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by ...

journal_title：Cancer investigation

authors： Kohli M,Williams K,Yao JL,Dennis RA,Huang J,Reeder J,Ricke WA

更新日期：2011-01-01 00:00:00

abstract：:The interaction of 5-fluorouracil and cyclophosphamide in the treatment of L1210 and P388 leukemias was studied using response surface methodology. Single dose treatment of each drug was administered simultaneously or with a 24-hr interval between 5-fluorouracil and cyclophosphamide to the advanced tumors or at variou...

journal_title：Cancer investigation

authors： Wampler GL,Carter WH Jr,Campbell ED

更新日期：1987-01-01 00:00:00

abstract：:Patients with metastatic prostate cancer resistant to hormones and docetaxel were treated with vinflunine (320 mg/m(2) every 21 days), a new vinca alkaloid with improved preclinical activity. Only 1 of 36 patients (3%) had partial response; the median progression-free survival (PFS) was 2.1 months. Treatment was well ...

journal_title：Cancer investigation

authors： Hainsworth JD,Meluch AA,Lane CM,Spigel DR,Burris HA 3rd,Gandhi JG,Crane EJ,Stipanov MA,Greco FA

更新日期：2010-03-01 00:00:00

abstract：:We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to b...

journal_title：Cancer investigation

authors： Gunduz E,Gunduz M,Ali MA,Beder L,Tamamura R,Katase N,Tominaga S,Yamanaka N,Shimizu K,Nagatsuka H

更新日期：2009-07-01 00:00:00

abstract：:The efficacy of dose-intense methotrexate, vinblastine, doxorubicin, and cisplatin (M-VAC) chemotherapy relative to conventional-dose M-VAC in patients with advanced transitional cell carcinoma is unknown. The outcomes of 33 patients on two successive protocols using dose-intense M-VAC with granulocyte colony-stimulat...

journal_title：Cancer investigation

authors： Dodd PM,McCaffrey JA,Mazumdar M,Scher H,Higgins G,Boyle MG,Herr H,Bajorin DF

更新日期：2000-01-01 00:00:00

abstract：:Enhanced proteolysis and altered tight junction (TJ) proteins associate with carcinoma invasion. We hypothesized that trypsin-2, a tumor-associated serine proteinase, induces tongue carcinoma invasion by activating pro-membrane type-1 matrix metalloproteinase (MT1-MMP) and disturbing the TJs. The effects of invasion w...

journal_title：Cancer investigation

authors： Vilen ST,Suojanen J,Salas F,Risteli J,Ylipalosaari M,Itkonen O,Koistinen H,Baumann M,Stenman UH,Sorsa T,Salo T,Nyberg P

更新日期：2012-10-01 00:00:00

abstract：:Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...

journal_title：Cancer investigation

authors： Chen YM,Vaughn CB

更新日期：1989-01-01 00:00:00

abstract：:Tumorigenesis is known to result from multiple genetic changes. Although endogenous and environmental insults can damage DNA, cellular mechanisms exist to repair various forms of damage or to kill those cells irreparably damaged. Hence, the accumulation of numerous genetic changes that would lead to cancer in normal c...

journal_title：Cancer investigation

authors： Jasin M

更新日期：2000-01-01 00:00:00

abstract：BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...

journal_title：Cancer investigation

authors： Anders C,Marcom PK,Peterson B,Gu L,Unruhe S,Welch R,Lyons P,Behera M,Copland S,Kimmick G,Shaw H,Snyder S,Antenos M,Woodruff T,Blackwell K

更新日期：2008-04-01 00:00:00

abstract：:We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...

journal_title：Cancer investigation

authors： Wzietek I,Suwinski R,Nowara E,Bialas M,Bentzen S,Tukiendorf A

更新日期：2014-01-01 00:00:00

abstract：:One hundred twenty-two early-stage anal canal cancer patients (median age: 69 years) were treated with curative radiotherapy with (70 patients) or without (52 patients) concomitant chemotherapy. Median follow-up was 65 months (range: 4-238). At multivariate analysis, concomitant chemotherapy significantly improved loc...

journal_title：Cancer investigation

authors： De Bari B,Lestrade L,Pommier P,Maddalo M,Buglione M,Magrini SM,Carrie C

更新日期：2015-04-01 00:00:00

abstract：:Malignant kidney tumors account for approximately 2% of all new primary cancer cases diagnosed in the United States, with an estimated 30,000 cases occurring annually. Although a variety of agents, chemical and biological, have been implicated as causal agents in the development of renal cell carcinoma (RCC), the etio...

journal_title：Cancer investigation

authors： Moore LE,Wilson RT,Campleman SL

更新日期：2005-01-01 00:00:00

abstract：:Radioimmunoscintigraphy (RIS) is coming into its own as an imaging modality in clinical oncology. Early experience with indium-111-labeled intact murine monoclonal antibodies (MoAbs) in colorectal cancer suggested that RIS images hepatic metastases poorly. Moreover, an antimurine immune response was frequently provoke...

journal_title：Cancer investigation

authors： Moffat FL Jr,Gulec SA,Serafini AN,Sfakianakis GN,Pop R,Robinson DS,Franceschi D,Boggs J,Livingstone AS

更新日期：1999-01-01 00:00:00

abstract：:Several recent studies have indicated that alterations in expression of major histocompatibility complex (MHC) antigens by tumor cells affects the ability of the host to mount an effective antitumor immune response. To investigate whether newly induced tumors frequently exhibit altered MHC antigen expression, we used ...

journal_title：Cancer investigation

authors： Reagan WJ,Pardi D,Callahan GN

更新日期：1991-01-01 00:00:00

abstract：:Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...

journal_title：Cancer investigation

authors： Shigetomi H,Tsunemi T,Haruta S,Kajihara H,Yoshizawa Y,Tanase Y,Furukawa N,Yoshida S,Sado T,Kobayashi H

更新日期：2012-07-01 00:00:00

abstract：:A natural tension exists as an IRB attempts of fulfill its mission of providing an independent and unbiased evaluation of a study while also insuring appropriate consideration of all relevant risks, benefits, and alternative strategies. IRB members with often critically relevant knowledge of unique issues involved in ...

journal_title：Cancer investigation

authors： Markman M

更新日期：2008-03-01 00:00:00

abstract：:Adjuvant and neoadjuvant chemotherapy is being used increasingly in the treatment of breast cancer patients. However, drug resistance plays an important role in the failure of chemotherapy in breast cancer. The aim of this study was to compare technetium-99m tetrofosmin (Tc-TETRO) mammoscintigraphic findings with the ...

journal_title：Cancer investigation

authors： Liu TJ,Tsai SC,Ho YJ,Sun SS,Kao CH

更新日期：2002-01-01 00:00:00

abstract：:PS-341, now known as bortezomib (Velcade[Millenium Pharmaceuticals, Inc., Cambridge, MA; and Johnson & Johnson Pharmaceutical Research & Development, LLC, Spring house, PA]), is a proteasome inhibitor approved for the treatment of refractory multiple myeloma. Preclinical and early clinical studies showed PS-341 to be ...

journal_title：Cancer investigation

authors： Engel RH,Brown JA,Von Roenn JH,O'Regan RM,Bergan R,Badve S,Rademaker A,Gradishar WJ

更新日期：2007-12-01 00:00:00