Lifestyle factors, exposures, genetic susceptibility, and renal cell cancer risk: a review.

abstract：:We have analyzed allelic loss of the short arm of chromosome 9 in 39 head and neck cancers using 13 polymorphic markers and found two deletions of hot spots at 9p21 and 9p24. Loss of heterozygosity was detected at least at one locus in 28 of 39 cases (71.8%). P16, a well-known tumor suppressor gene, is considered to b...

journal_title：Cancer investigation

authors： Gunduz E,Gunduz M,Ali MA,Beder L,Tamamura R,Katase N,Tominaga S,Yamanaka N,Shimizu K,Nagatsuka H

更新日期：2009-07-01 00:00:00

abstract：:Ubiquitin ligase Cullin7 has been has been suggested to act as an oncogene in some tumors; however, the prognostic role of Cullin7 has not been evaluated in cancer patients. In this study, we observed that the expression of Cullin7 mRNA was significantly higher in epithelial ovarian cancer (EOC) compared with normal o...

journal_title：Cancer investigation

authors： Xi J,Zeng ST,Guo L,Feng J

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...

journal_title：Cancer investigation

authors： Chang VT,Hwang SS,Kasimis B,Thaler HT

更新日期：2004-01-01 00:00:00

abstract：:This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...

journal_title：Cancer investigation

authors： Hardy WD Jr

更新日期：1983-01-01 00:00:00

abstract：:Between March 1986 and December 1987, two groups of consecutive patients with advanced breast cancer underwent epidoxorubicin (Epidx) monochemotherapy. Twenty-three patients (group A) received Epidx at a dose of 60 mg/m2 and 27 (group B) at a dose of 120 mg/m2 (i.v. every 3 weeks). No patient had undergone anthracycli...

journal_title：Cancer investigation

authors： Neri B,Pacini P,Algeri R,Lottini G,Rinaldini M,Tucci E,Pusterla R

更新日期：1993-01-01 00:00:00

abstract：PURPOSE:This Phase II study was undertaken to define the efficacy and toxicity of the combination of docetaxel and irinotecan for the second-line treatment of non-small cell lung cancer (NSCLC). PATIENTS AND METHODS:Forty-six patients with measurable NSCLC who had relapsed after an initial response to chemotherapy or ...

journal_title：Cancer investigation

authors： Molina JR,Nikcevich D,Hillman S,Geyer S,Drevyanko T,Jett J,Verdirame J,Tazelaar H,Rowland K,Wos E,Kutteh L,Nair S,Fitch T,Flynn P,Stella P,Adjei AA

更新日期：2006-06-01 00:00:00

abstract：:A small subset of cells in a patient with leukemia, termed leukemic stem cells (LSCs) have been shown to be responsible for the proliferation of disease. LSCs are thought to derive from normal hematopoietic stem cells, but are phenotypically distinguishable in that they are CD90(-), CD117(-), and CD123(+). Research in...

journal_title：Cancer investigation

authors： O'Brien JA,Rizzieri DA

更新日期：2013-05-01 00:00:00

abstract：:Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...

journal_title：Cancer investigation

authors： Aragona M,Panetta S,Silipigni AM,Romeo DL,Pastura G,Mesiti M,Cascinu S,La Torre F

更新日期：2001-01-01 00:00:00

abstract：:Enthusiasms into the application of PI3K-δ inhibitor CAL-101 has been muted due to the over-activation of compensatory molecules. Our results delineated that c-Myc suppression using 10058-F4 enhanced CAL-101 cytotoxicity in less sensitive cells through different mechanisms based on p53 status; while CAL-101-plus-10058...

journal_title：Cancer investigation

authors： Riyahi N,Safaroghli-Azar A,Sheikh-Zeineddini N,Sayyadi M,Bashash D

更新日期：2019-01-01 00:00:00

abstract：:Following is a review of altered fractionation in radiation therapy for head and neck cancer. The goals of altered fractionation are to increase local-regional control and/or reduce the risk of late complications. Altered fractionation schedules can be broadly classified as accelerated fractionation and hyperfractiona...

journal_title：Cancer investigation

authors： Mendenhall WM,Parsons JT

更新日期：1998-01-01 00:00:00

abstract：:Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...

journal_title：Cancer investigation

authors： Agah S,Akbari A,Talebi A,Masoudi M,Sarveazad A,Mirzaei A,Nazmi F

更新日期：2017-11-26 00:00:00

abstract：:Non-invasive pharmacological management of patients with cancer related pain has resulted in pain control in 90-95% of the patients. Thus, 5-10% of patients still experience inadequate pain control despite aggressive combined pharmacological therapy. Moreover, patients may not tolerate an aggressive program of titrati...

journal_title：Cancer investigation

authors： de Leon-Casasola OA

更新日期：2004-01-01 00:00:00

abstract：:Tumor-infiltrating leukocytes and other immunohistochemical parameters were evaluated in pretherapeutic biopsies and resection specimens in 73 patients undergoing neoadjuvant chemotherapy with doxorubicin and paclitaxel. Ten patients with pathological complete response had significantly higher p53 expression, CD3(+) l...

journal_title：Cancer investigation

authors： Hornychova H,Melichar B,Tomsova M,Mergancova J,Urminska H,Ryska A

更新日期：2008-12-01 00:00:00

abstract：:Soluble CTLA4 (sCTLA4) was assessed in sera of 43 new cases with breast cancer and 44 age- and sex-matched healthy individuals by enzyme-linked immunosorbent assay method. Associations of sCTLA4 levels with the six important CTLA4 Single Nucleotide Polymorphisms (SNPs) and with the resulted haplotypes were investigate...

journal_title：Cancer investigation

authors： Erfani N,Razmkhah M,Ghaderi A

更新日期：2010-10-01 00:00:00

abstract：:The sponge matrix allograft model made possible the growth of an AKR lymphoma in a certain percentage of BALB/c mice making progressors (tumor-bearing) and regressors (tumor-rejecting) simultaneously available. Mice bearing either an AKR kidney allograft or a sponge alone were used as controls. The cell population inf...

journal_title：Cancer investigation

authors： Barrera CN,Mazzolli AB,Bustuoabad OD,Andreetta AM,Pasqualini CD

更新日期：1985-01-01 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Premenopausal women treated for early stage breast cancer (ESBC) are at risk for chemotherapy-related amenorrhea (CRA). Prospectively-validated, predictive markers of CRA are needed. PATIENTS AND METHODS:Premenopausal women with ESBC and planned chemotherapy (>/= 25% risk of amenorrhea) were evaluated. Foll...

journal_title：Cancer investigation

authors： Anders C,Marcom PK,Peterson B,Gu L,Unruhe S,Welch R,Lyons P,Behera M,Copland S,Kimmick G,Shaw H,Snyder S,Antenos M,Woodruff T,Blackwell K

更新日期：2008-04-01 00:00:00

abstract：:The present study examines the effect of tobacco smoking on the expression of cyclooxygenase (COX)-2 gene, COX enzymatic activity and prostaglandin (PG) synthesis in urothelial mucosal tissues from patients with bladder cancer and from normal individuals. The detection frequency of COX-2 mRNA was 2-fold higher in blad...

journal_title：Cancer investigation

authors： Badawi AF,Habib SL,Mohammed MA,Abadi AA,Michael MS

更新日期：2002-01-01 00:00:00

abstract：:Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...

journal_title：Cancer investigation

authors： Bogush TA,Polezhaev BB,Mamichev IA,Bogush EA,Polotsky BE,Tjulandin SA,Ryabov AB

更新日期：2018-04-21 00:00:00

abstract：:Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...

journal_title：Cancer investigation

authors： Shigetomi H,Tsunemi T,Haruta S,Kajihara H,Yoshizawa Y,Tanase Y,Furukawa N,Yoshida S,Sado T,Kobayashi H

更新日期：2012-07-01 00:00:00

abstract：:Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...

journal_title：Cancer investigation

authors： Daugherty CK

更新日期：2004-01-01 00:00:00

abstract：:We performed the analysis of database on 409 patients with LD-SCLC to evaluate as to what extent the clinical outcome of large prospective trials was reproduced in routine practice. The analysis has shown that the hazard rate of death in the absence of prophylactic cranial irradiation (PCI) adjusted for the effects of...

journal_title：Cancer investigation

authors： Wzietek I,Suwinski R,Nowara E,Bialas M,Bentzen S,Tukiendorf A

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:Patients with systemic malignancies have substantial quantities of tumor-specific DNA in their plasma which may serve as a potential biomarker for tumor burden. This approach has not been studied in gliomas. METHODS:Methylation specific polymerase chain reaction (MSP) was used to determine the methylation st...

journal_title：Cancer investigation

authors： Weaver KD,Grossman SA,Herman JG

更新日期：2006-02-01 00:00:00

abstract：:The aim of the current study was to determine the signaling differences between gamma- and proton beam-irradiations. A549 lung adenocarcinoma cells were irradiated with 2 Gy proton beam or gamma-radiation. Proton beam was found to be more cytotoxic than gamma-radiation. Proton beam-irradiated cells showed phosphorylat...

journal_title：Cancer investigation

authors： Ghosh S,Bhat NN,Santra S,Thomas RG,Gupta SK,Choudhury RK,Krishna M

更新日期：2010-07-01 00:00:00

abstract：:Promoter DNA hypermethylation of APC, DAPK, and GSTP1 genes was evaluated in biopsy and matched serum of 160 lung cancer patients and 70 controls. In biopsy, 83.1, 83.1, and 78.1% of lung cancer patients and 72.9, 70, and 70% of controls, while in serum, 52.5, 30.6, and 65.6% of lung cancer patients and 14.3, 18.6, an...

journal_title：Cancer investigation

authors： Ali A,Kumar S,Kakaria VK,Mohan A,Luthra K,Upadhyay AD,Guleria R

更新日期：2017-07-03 00:00:00

abstract：:The vinca alkaloids represent one of the oldest classes of antineoplastic agents used in humans with a wide spectrum of activity against both animal and human tumors. These agents are known to inhibit microtubule polymerization. Vinorelbine is a semisynthetic analog that reached clinical trial on the basis of less pre...

journal_title：Cancer investigation

authors： Budman DR

更新日期：1997-01-01 00:00:00

abstract：:As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...

journal_title：Cancer investigation

authors： Halbert CH,Kessler LJ,Mitchell E

更新日期：2005-01-01 00:00:00

abstract：:Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...

journal_title：Cancer investigation

authors： Lopez-Berestein G,Cabanillas F,Osborne BM,Libshitz HI,Bodey GP

更新日期：1983-01-01 00:00:00

abstract：:The anticancer effects of synthetic, non-natural analogs of ceramide were tested using human TSU-Pr1 prostate cancer cells in-vitro as well as in-vivo, following their effects on tumors development in mice. When incubated with the cultured cancer cells, the analogs elevated cellular ceramide and induced a cytotoxicity...

journal_title：Cancer investigation

authors： Qin JD,Weiss L,Slavin S,Gatt S,Dagan A

更新日期：2010-06-01 00:00:00

abstract：:The interaction of 5-fluorouracil and cyclophosphamide in the treatment of L1210 and P388 leukemias was studied using response surface methodology. Single dose treatment of each drug was administered simultaneously or with a 24-hr interval between 5-fluorouracil and cyclophosphamide to the advanced tumors or at variou...

journal_title：Cancer investigation

authors： Wampler GL,Carter WH Jr,Campbell ED

更新日期：1987-01-01 00:00:00