Ectopically expressed IBP promotes cell proliferation in oral squamous cell carcinoma.

abstract：:Glioma stem cells (GSCs) play major roles in drug resistance, tumour maintenance and recurrence of glioblastoma. We investigated inhibition of the GTPase dynamin 2 as a therapy for glioblastoma. Glioma cell lines and patient-derived GSCs were treated with dynamin inhibitors, Dynole 34-2 and CyDyn 4-36. We studied abou...

journal_title：Cancer investigation

authors： Luwor R,Morokoff AP,Amiridis S,D'Abaco G,Paradiso L,Stylli SS,Nguyen HPT,Tarleton M,Young KA,O'Brien TJ,Robinson PJ,Chircop M,McCluskey A,Jones NC

更新日期：2019-01-01 00:00:00

abstract：:Cells from 11 chronic lymphocytic leukemic (CLL) patients were induced to differentiate with various doses of tetradecanoyl phorbol-13-acetate (TPA) and the degree of induction was followed up to six days by measuring the expression of two surface membrane markers (SmIg and GP-70), Ig secretion, tartrate-resistant aci...

journal_title：Cancer investigation

authors： Gazitt Y,Gurfel D,Leizerowitz R,Feinstein H,Polliack A

更新日期：1987-01-01 00:00:00

abstract：:Prostate-specific antigen (PSA) test is limited in prostate cancer diagnosis due to its inaccuracy. A new approach which integrates the PSA test with miRNA profiling was investigated to improve prostate cancer diagnosis. Six prostate cancer-related miRNAs (miR-16, -21, -34c, -101, -125b, -141) were tested in five cult...

journal_title：Cancer investigation

authors： Hao Y,Zhao Y,Zhao X,He C,Pang X,Wu TC,Califano JA,Gu X

更新日期：2011-05-01 00:00:00

abstract：:This case control study investigated whether polymorphisms of estrogen metabolizing genes CYP1A1 MspI, CYP17 MspAI, COMT Val(158) Met, and SULT1A1 Arg(213) His have any role in familial breast cancer susceptibility risk. Logistic regression analysis adjusted to age was used to calculate odds ratios (ORs) and 95% confi...

journal_title：Cancer investigation

authors： Syamala VS,Syamala V,Sheeja VR,Kuttan R,Balakrishnan R,Ankathil R

更新日期：2010-03-01 00:00:00

abstract：:We analyzed the clinical utility of molecular classification based on anatomical and histological background. The study was conducted on 457 patients treated for gastric cancer with additional information about microsatellite instability status. We divided the patients in three groups of molecular classification based...

journal_title：Cancer investigation

authors： Polom K,Marrelli D,Roviello G,Voglino C,Vindigni C,Generali D,Roviello F

更新日期：2017-05-28 00:00:00

abstract：:The anticancer effects of synthetic, non-natural analogs of ceramide were tested using human TSU-Pr1 prostate cancer cells in-vitro as well as in-vivo, following their effects on tumors development in mice. When incubated with the cultured cancer cells, the analogs elevated cellular ceramide and induced a cytotoxicity...

journal_title：Cancer investigation

authors： Qin JD,Weiss L,Slavin S,Gatt S,Dagan A

更新日期：2010-06-01 00:00:00

abstract：:This study is to evaluate the association between IL-8 -251A/T polymorphism and lung cancer risk in diverse populations. We performed a meta-analysis of six case-control studies that included 3,265 lung-cancer cases and 3,607 case-free controls. Overall, results showed that the IL-8 -251A/T polymorphism was not associ...

journal_title：Cancer investigation

authors： Gao P,Zhao H,You J,Jing F,Hu Y

更新日期：2014-12-01 00:00:00

abstract：PURPOSE:The decision concerning adjuvant therapy remains difficult in patients with very early stage ovarian carcinomas [Fédération Internationale de Gynécologie et d' Obstétrique (FIGO) Ia/b]. Therefore, we compared the MIB1-determined tumor growth fraction in archival tumor tissue with tumor recurrence and outcome of...

journal_title：Cancer investigation

authors： Münstedt K,von Georgi R,Franke FE

更新日期：2004-01-01 00:00:00

abstract：:SNPs in CYP1A1, CYP2A1, CYP2B6, CYP2C, CYP2D6, CYP3A, GSTM1, GSTT1, GSTP1, SULT1A1, SULT1A2, UGT, and MTHFR are associated with breast cancer susceptibility; however, lack of such associations are also reported in some populations. The contradictory findings are explained on the basis of ethnic variation among populat...

journal_title：Cancer investigation

authors： Singh V,Parmar D,Singh MP

更新日期：2008-10-01 00:00:00

abstract：:Fingerprints from 200 women with histologically proven breast cancer (case group) were compared to fingerprints from 138 women with no history of any malignant disease (control group). Of the patterns analyzed, four were significantly associated with breast cancer: accidentals, transitionals, angled ulnar loops, and h...

journal_title：Cancer investigation

authors： Bierman HR,Faith MR,Stewart ME

更新日期：1988-01-01 00:00:00

abstract：:In summary, anemia developing in a patient with cancer can be due to several different factors. A relative failure of erythropoiesis, in conjunction with a modestly shortened erythrocyte survival, is the most likely explanation for the anemia and can occur in patients with or without bone marrow invasion. Several theo...

journal_title：Cancer investigation

authors： Zucker S

更新日期：1985-01-01 00:00:00

abstract：:CXCL12 is an extracellular chemokine binding to cell surface receptor CXCR4. We found that activation of CXCL12/CXCR4 axis stimulated angiogenesis in endothelial cells. Knockdown of CXCR4 in endothelial cells prevented the branch points of angiogenesis. Endothelial cells exposed to CXCL12 presented high level of epide...

journal_title：Cancer investigation

authors： Song ZY,Wang F,Cui SX,Qu XJ

更新日期：2018-01-02 00:00:00

abstract：:Human papillomaviruses (HPVs) and BKV, JCV, and SV40 polyomaviruses (PYVs) are oncogenic viruses associated with different human tumors. Our aim was to determine if PYV and HPV sequences could be detected in human genital tumors. HPV types 6b, 11, 16, and 18 and PYV were investigated in 22 genital tumor samples and th...

journal_title：Cancer investigation

authors： Martini F,Iaccheri L,Martinelli M,Martinello R,Grandi E,Mollica G,Tognon M

更新日期：2004-01-01 00:00:00

abstract：:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...

journal_title：Cancer investigation

authors： Schattner EJ

更新日期：2002-01-01 00:00:00

abstract：:Soft tissue sarcomas are generally resistant to most chemotherapeutic agents, and individuals with advanced disease have a poor prognosis. We evaluated amonafide, a new drug that has significant activity against several tumor cell lines, to determine its activity against sarcomas. Amonafide was administered to 18 pati...

journal_title：Cancer investigation

authors： Buys SS,Metch B,Balcerzak SP,Neefe JR,Stuckey WJ

更新日期：1994-01-01 00:00:00

abstract：:N- and K-ras mutations at codons 12 and 13 were investigated using oligonucleotide hybridization analysis after PCR amplification and subsequent sequence analysis of the amplified DNA from the region of interest in the following prostatic primary and metastatic (met) carcinoma-derived cell lines: 1013L (primary), PC3 ...

journal_title：Cancer investigation

authors： Pergolizzi RG,Kreis W,Rottach C,Susin M,Broome JD

更新日期：1993-01-01 00:00:00

abstract：:Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...

journal_title：Cancer investigation

authors： Lopez-Berestein G,Cabanillas F,Osborne BM,Libshitz HI,Bodey GP

更新日期：1983-01-01 00:00:00

abstract：:Ammonium sulfate (AS) precipitation by consecutive steps at 10% to 50% saturation has been utilized for fractionation of cytoplasmic estrogen receptor (ER) and progesterone receptor (PgR). The highest percentage of both receptor activities are confined mainly in two fractions at AS saturation from 20% to 30% and 30% t...

journal_title：Cancer investigation

authors： Chen YM,Vaughn CB

更新日期：1989-01-01 00:00:00

abstract：:Acute promyelocytic leukemia (APL) is characterized by specific t(15;17), distinct morphologic picture, and clinical coagulopathy that contribute to the morbidity and mortality of the disease. This study aims to investigate the effects of antitelomerase compound BIBR1532 on APL cells (NB4). BIBR 1532 exerts a direct s...

journal_title：Cancer investigation

authors： Bashash D,Ghaffari SH,Zaker F,Hezave K,Kazerani M,Ghavamzadeh A,Alimoghaddam K,Mosavi SA,Gharehbaghian A,Vossough P

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this study was to assess the usefulness of thallium-201 (Tl-201) single-photon emission-computed tomography (SPECT) scintimammography to differentiate benign from malignant breast masses in 32 female Taiwanese patients with indeterminate mammographic probability of malignancy because of mammographically...

journal_title：Cancer investigation

authors： Chiou JF,Lin MC,Chen DR,Jim YF,Kao CH

更新日期：2003-01-01 00:00:00

abstract：:CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...

journal_title：Cancer investigation

authors： Voigt H,Vetter-Kauczok CS,Schrama D,Hofmann UB,Becker JC,Houben R

更新日期：2009-03-01 00:00:00

abstract：:Because most cancer deaths result from disseminated disease, understanding the regulation of tumor invasion and metastasis is a central theme in tumor cell biology. Interactions between extracellular matrices (ECM) and cellular microenvironment play a crucial role in this process. We have tested selected amino acids a...

journal_title：Cancer investigation

authors： Singh RK,Rinehart CA,Kim JP,Tolleson-Rinehart S,Lawing LF,Kaufman DG,Siegal GP

更新日期：1996-01-01 00:00:00

abstract：:In this study, we evaluated SEA-H61D, a staphylococcal enterotoxin A mutant without emetic activity, as an antitumor agent in vitro and in vivo. It showed that SEA-H61D could significantly inhibit the growth of many cancer cell lines in vitro at very low concentrations by activating human peripheral blood mononuclear ...

journal_title：Cancer investigation

authors： Wang HR,Jiang H,Hao HJ,Zheng YL,Jie KG,Gu J,Jiang YQ

更新日期：2010-10-01 00:00:00

abstract：:In vivo and in vitro observations of cellular immune response in 70 patients with squamous cell cancer of the oral cavity and in 40 age-matched normal controls, were made using delayed hypersensitivity responses to DNCB, PPD, and Candida albicans extract (Dermatophytin 'O'), absolute lymphocyte counts, absolute T-cell...

journal_title：Cancer investigation

authors： Das SN,Khanna NN,Khanna S

更新日期：1986-01-01 00:00:00

abstract：:We studied the production of chemiluminescence (CL) by peripheral blood neutrophils from 24 normal subjects, 13 lung cancer patients with clinical stages (CS) III and IV, and 27 breast cancer patients with CS II, III, and IV. Evaluations were made before chemo- and radiotherapy treatments. CL was expressed as: baselin...

journal_title：Cancer investigation

authors： Chasseing NA,Barañao RI,Fernández O,Bordenave H,Rumi LS

更新日期：1993-01-01 00:00:00

abstract：:A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR:...

journal_title：Cancer investigation

authors： Xie X,Liu J,Yang H,Chen H,Zhou S,Lin H,Liao Z,Ding Y,Ling L,Wang X

更新日期：2019-01-01 00:00:00

abstract：:The present study investigates the association between IL12Bpro and +16974A/C in 3' -untranslated region (UTR) polymorphisms of IL12B and IL-12p40 serum level related to development of colorectal cancer (CRC). Our results showed similar distribution of both the investigated polymorphisms among CRC patients and healthy...

journal_title：Cancer investigation

authors： Miteva L,Stanilov N,Deliysky T,Mintchev N,Stanilova S

更新日期：2009-11-01 00:00:00

abstract：:Thirty patients with a diagnosis of metastatic adenocarcinoma of the lung were entered on a trial to evaluate the antitumor efficacy of 5-fluorouracil 370 mg/m2 daily for 5 days every four weeks in combination with folinic acid 200 mg/m2, 60 min prior to 5FU. All patients had a good performance status, bidimensionally...

journal_title：Cancer investigation

authors： Evans WK,Wierzbicki R,Shepherd FA,Rusthoven J,Stewart DJ,Aitken SE,Maroun JA,Ezzat A

更新日期：1990-01-01 00:00:00

abstract：:To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...

journal_title：Cancer investigation

authors： Augoff K,Grabowski K,Rabczynski J,Kolondra A,Tabola R,Sikorski AF

更新日期：2009-05-01 00:00:00

abstract：:Doxorubicin and paclitaxel are highly active agents in the treatment of advanced breast cancer. Although early trials of the combination reported high response rates, an unexpectedly high incidence of congestive heart failure observed on two of the early trials was cause for much concern. More recently, clinical trial...

journal_title：Cancer investigation

authors： Perez EA

更新日期：2001-01-01 00:00:00