Abstract:
:The anticancer effects of synthetic, non-natural analogs of ceramide were tested using human TSU-Pr1 prostate cancer cells in-vitro as well as in-vivo, following their effects on tumors development in mice. When incubated with the cultured cancer cells, the analogs elevated cellular ceramide and induced a cytotoxicity and death by apoptosis. When a ceramide analog was injected intradermally or intraperitoneally into BALB/c-Nude or NOD-SCID mice bearing a human prostate tumor, a considerable regression of the tumor was observed. The synthetic ceramide analogs should thus be further investigated as potential anticancer drugs.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Qin JD,Weiss L,Slavin S,Gatt S,Dagan Adoi
10.3109/07357900903478915subject
Has Abstractpub_date
2010-06-01 00:00:00pages
535-43issue
5eissn
0735-7907issn
1532-4192journal_volume
28pub_type
杂志文章abstract::Although it is not proven by causative association, several studies indicate that patients with acquired immune deficiency syndrome (AIDS) have a high risk for developing cutaneous malignancies, especially lymphoma and Kaposi's sarcoma. Other malignant cutaneous lesions seen in this patient population include basal-ce...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909809039770
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909909021423
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journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357900009023055
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journal_title:Cancer investigation
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journal_title:Cancer investigation
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journal_title:Cancer investigation
pub_type: 杂志文章
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journal_title:Cancer investigation
pub_type: 杂志文章
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journal_title:Cancer investigation
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abstract::A series of 3-aryl/hetarylquinoxaline-2-carbonitrile-1,4-dioxides was synthesized and evaluated against breast cancer cell lines in normoxia and hypoxia. Selected compounds in this series demonstrated better cytotoxicity and comparable hypoxia selectivity than tirapazamine. In contrast to Dox, quinoxaline-1,4-dioxides...
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pub_type: 杂志文章
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journal_title:Cancer investigation
pub_type: 杂志文章
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2012-12-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2016-11-25 00:00:00
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pub_type: 杂志文章,多中心研究
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更新日期:2010-03-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100000069
更新日期:2001-01-01 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012191
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journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357908809077025
更新日期:1988-01-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2018-01-02 00:00:00
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journal_title:Cancer investigation
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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abstract:BACKGROUND:Rapid and efficient symptom assessment is an important aspect of palliative care. The objective was to determine whether a smaller number of symptoms from the 32-item Memorial Symptom Assessment Scale Short-Form (MSAS-SF) could convey equivalent quality of life (QOL) information. METHODS:Responses from 479 ...
journal_title:Cancer investigation
pub_type: 杂志文章
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journal_title:Cancer investigation
pub_type: 杂志文章,评审
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更新日期:2010-12-01 00:00:00
abstract::Decisive indulgence of angiogenesis requires a more holistic assessment and several in vivo assays have been developed that permit a more realistic appraisal of the angiogenic response. One of the most popular assays to study angiogenic activity is the chick chorioallantoic membrane (CAM). Although CAM assay is a vita...
journal_title:Cancer investigation
pub_type: 杂志文章
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更新日期:2006-10-01 00:00:00