Abstract:
:The present study examines the effect of tobacco smoking on the expression of cyclooxygenase (COX)-2 gene, COX enzymatic activity and prostaglandin (PG) synthesis in urothelial mucosal tissues from patients with bladder cancer and from normal individuals. The detection frequency of COX-2 mRNA was 2-fold higher in bladder cancer patients compared to controls and it was accompanied by a significantly increased COX enzymatic activity and PGE2 synthesis (p < 0.05). Smokers, in both control and patients groups, had higher COX-2 expression, COX activity, and PGE2 synthesis compared to the nonsmokers (p < 0.05). The number of cigarettes smoked in the cases, but not controls, correlated well with COX enzymatic activity (r = 0.42, p = 0.016). The observed over-expression of COX-2 gene in human urinary bladder and the concomitant increases in PG synthesis may explain, at least in part, the mechanism by which cigarette smoking influences the development of urothelial neoplasia.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Badawi AF,Habib SL,Mohammed MA,Abadi AA,Michael MSdoi
10.1081/cnv-120002490subject
Has Abstractpub_date
2002-01-01 00:00:00pages
651-6issue
5-6eissn
0735-7907issn
1532-4192journal_volume
20pub_type
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