Chemo/radiotherapy-Induced Bone Marrow Niche Alterations.

abstract：BACKGROUND:Hand-foot syndrome (HFS) has been previously reported as a side effect in 45-56% of patients treated with capecitabine. However, the natural history of HFS has not been fully characterized. In this study, we investigate the incidence, severity, and time course of HFS. DESIGN:Toxicity data collected for 41 p...

journal_title：Cancer investigation

authors： Abushullaih S,Saad ED,Munsell M,Hoff PM

更新日期：2002-01-01 00:00:00

abstract：:Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...

journal_title：Cancer investigation

authors： Schattner EJ

更新日期：2002-01-01 00:00:00

abstract：:Based on a preliminary trial that suggested that CHOP (cyclophosphamide, doxorubicin, vincristine, prednisone), and PVB (cisplatinum, vinblastine, bleomycin), are at least partially non-cross-resistant, the Southwest Oncology Group treated patients with unfavorable histology, non-Hodgkin's lymphoma with CHOP and PVB. ...

journal_title：Cancer investigation

authors： Dabich L,Dahlberg S,Hartsock RJ,LoBuglio AF,Liepman MK,Grozea PN,Eyre HJ,Weick JK,Bonnet JD,Coltman CA Jr

更新日期：1991-01-01 00:00:00

abstract：:The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed ...

journal_title：Cancer investigation

authors： Viñolas N,Garrido P,Isla D,Provencio M,Majem M,Artal A,Carcereny E,Garcia Campelo R,Lianes P,De La Peñas R,Felip E

更新日期：2017-05-28 00:00:00

abstract：:Placement of carmustine-impregnated wafers has become a common practice after surgical resection of malignant gliomas. Bevacizumab is used as a second-line agent for the treatment of malignant gliomas and is sometimes used in patients who have had recent wafer implantation. We describe two cases of fatal cerebrospinal...

journal_title：Cancer investigation

authors： Nagaiah G,Almubarak M,Khan M,Altaha R

更新日期：2010-12-01 00:00:00

abstract：:Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...

journal_title：Cancer investigation

authors： Olsen RS,Dimberg J,Geffers R,Wågsäter D

更新日期：2019-01-01 00:00:00

abstract：:For women with hormone receptor-positive disease, the third-generation aromatase inhibitors (AIs), anastrozole, letrozole, and exemestane, are more effective than tamoxifen in improving disease-free survival (DFS) when used initially or as adjuvant therapy following two to three years of tamoxifen or after tamoxifen h...

journal_title：Cancer investigation

authors： Tang SC

更新日期：2008-06-01 00:00:00

abstract：:In the present study, we assessed the expression of extracellular matrix (ECM) degrading proteases-cathepsin L and matrix metalloprotease-2 (MMP-2) in pancreatic cancer tissue and correlated their levels with clinicopathological parameters and survival. Both the proteases were expressed in the majority of the tumor ti...

journal_title：Cancer investigation

authors： Singh N,Das P,Datta Gupta S,Sahni P,Pandey RM,Gupta S,Chauhan SS,Saraya A

更新日期：2013-08-01 00:00:00

abstract：:Human papillomaviruses (HPVs) and BKV, JCV, and SV40 polyomaviruses (PYVs) are oncogenic viruses associated with different human tumors. Our aim was to determine if PYV and HPV sequences could be detected in human genital tumors. HPV types 6b, 11, 16, and 18 and PYV were investigated in 22 genital tumor samples and th...

journal_title：Cancer investigation

authors： Martini F,Iaccheri L,Martinelli M,Martinello R,Grandi E,Mollica G,Tognon M

更新日期：2004-01-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...

journal_title：Cancer investigation

authors： Cascinu S,Del Ferro E,Ligi M,Staccioli MP,Giordani P,Catalano V,Agostinelli R,Muretto P,Catalano G

更新日期：2001-01-01 00:00:00

abstract：INTRODUCTION:A variable repertoire of coagulation protein expression is observed in different cancers. We evaluated expression of thrombin in prostate tissue. METHODS:Detection of thrombin was performed using quantitative real-time PCR in fresh tissue and in situ hybridization (ISH) in archival prostate tissue and by ...

journal_title：Cancer investigation

authors： Kohli M,Williams K,Yao JL,Dennis RA,Huang J,Reeder J,Ricke WA

更新日期：2011-01-01 00:00:00

abstract：:Although PKCs are assumed to be the main targets of phorbol esters (PMA), additional PMA effectors, such as chimaerins (a family of RacGTPase activating proteins) and RasGRP (exchange factor for Ras/Rap1), can counteract or strengthen the PKC pathways. In this study, we evaluated the proliferative behavior of PMA-trea...

journal_title：Cancer investigation

authors： Fortino V,Torricelli C,Capurro E,Sacchi G,Valacchi G,Maioli E

更新日期：2008-02-01 00:00:00

abstract：:A patient with cervical metastases leading to the diagnosis of a primary breast cancer is presented. To better define the frequency, symptoms, and characteristics of breast cancer metastasizing to the uterine cervix, all cases reported in the literature since 1950 are reviewed. This analysis reveals that in 21% of the...

journal_title：Cancer investigation

authors： Hepp HH,Hoos A,Leppien G,Wallwiener D

更新日期：1999-01-01 00:00:00

abstract：:It is believed that telomerase is a terminal effector and its role is to maintain the length of telomeres. However, the main rate-limiting subunit of telomerase, human telomerase reverse transcriptase (hTERT), has been recently proved to have the ability to affect a variety of other genes such as p53 independently of ...

journal_title：Cancer investigation

authors： Luo Y,Yi Y,Yao Z

更新日期：2009-12-01 00:00:00

abstract：:Hospice programs do not identify burnout as a significant staff problem, even though there are many significant stressors for staff members doing hospice work. Hospices offer support in a wide variety of ways and settings through their human resources management. All this support is predicated on the assumption that t...

journal_title：Cancer investigation

authors： Brenner PR

更新日期：1997-01-01 00:00:00

abstract：:Achieving a cure for metastatic neuroblastoma remains a challenge despite sensitivity to chemotherapy and radiotherapy. Most patients achieve remission, but a failure to eliminate minimal residual disease (MRD) often leads to relapse. Immunotherapy is potentially useful for chemotherapy-resistant disease and may be pa...

journal_title：Cancer investigation

authors： Modak S,Cheung NK

更新日期：2007-02-01 00:00:00

abstract：:The addition of corticosteroids in the early 1950s to the treatment armamentarium provided cure of some diseases and control of many. They have become an integral part of many cancer treatment regimens. Early reports of severe affective disorders appear less frequent today in patients receiving steroids, though contro...

journal_title：Cancer investigation

authors： Stiefel FC,Breitbart WS,Holland JC

更新日期：1989-01-01 00:00:00

abstract：:As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...

journal_title：Cancer investigation

authors： Halbert CH,Kessler LJ,Mitchell E

更新日期：2005-01-01 00:00:00

abstract：BACKGROUND:Although treatment-related lymphopenia (TRL) is common in many cancers no data exists in rectal cancer. METHODS:Serial lymphocyte counts were analyzed retrospectively in patients with newly diagnosed rectal cancer, serial blood counts, and complete records at Johns Hopkins Hospital. RESULTS:Fifty-seven pat...

journal_title：Cancer investigation

authors： Campian JL,Ye X,Sarai G,Herman J,Grossman SA

更新日期：2018-01-01 00:00:00

abstract：:Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...

journal_title：Cancer investigation

authors： Tehan L,Taparra K,Phelan S

更新日期：2013-07-01 00:00:00

abstract：:Abnormal p53 immunohistochemical pattern (p53-AP) including overexpression, complete absence and heterogeneity is surrogate of TP53 mutation. Using 742 cases of colorectal cancer (CRC), we show p53-AP is more common among type 2 diabetes (T2DM) patients than non-T2DM. Univariately, T2DM was significantly associated wi...

journal_title：Cancer investigation

authors： Yang Z,Ma J,Qi G,Zhang X

更新日期：2021-01-01 00:00:00

abstract：:The limited capacity to divide is one of the major differences between normal somatic cells and cancerous cells. This 'finite life span' of somatic cells is closely linked to loss of telomeric DNA at telomeres, the 'chromosome caps' consisting of repeated (7TAGGG) sequences., In more than 85% of advanced cancers, this...

journal_title：Cancer investigation

authors： Helder MN,Wisman GB,van der Zee GJ

更新日期：2002-01-01 00:00:00

abstract：:Previous studies have shown that human PSP94 can inhibit the growth of prostate cancer cells both in vitro and in vivo. To further validate this potential and investigate the protein within a homologous setting, we examined the effects of rat PSP94 on the growth of the rat prostate adenocarcinoma cell line PAIII in vi...

journal_title：Cancer investigation

authors： Cadieux PA,Mikolajczak SA,Reeves J,Strathdee C,Reid G,Panchal CJ,Clarke MW

更新日期：2006-04-01 00:00:00

abstract：:Advances in molecular methodology have resulted in the successful genetic mapping and isolation of the genes responsible for numerous simple Mendelian disorders such as cystic fibrosis, neurofibromatosis, and Huntington disease. Recently, researchers have begun to successfully study diseases with more complex inherita...

journal_title：Cancer investigation

authors： Foroud T

更新日期：1997-01-01 00:00:00

abstract：:Hepatitis B virus X protein (HBx) promotes hepatocellular carcinoma (HCC) invasion and metastasis by a poorly understood mechanism. This study investigated the role of NF-kappa B in HBx-mediated upregulation of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs). In a stably expressing HBx c...

journal_title：Cancer investigation

authors： Liu LP,Liang HF,Chen XP,Zhang WG,Yang SL,Xu T,Ren L

更新日期：2010-06-01 00:00:00

abstract：:Neurological paraneoplastic syndromes are exceedingly rare, and often difficult to recognize clinically. Paraneoplastic achalasia is a condition characterized by new-onset dysphagia that is unrelated to tumor burden, most often due to the development of auto-immune antibodies targeting esophageal tissue. Due to the ra...

journal_title：Cancer investigation

authors： Baniel CC,Donaldson SS,Aftandilian C,Hiniker SM

更新日期：2021-01-06 00:00:00

abstract：:The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

journal_title：Cancer investigation

authors： Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

更新日期：2008-08-01 00:00:00

abstract：:An elderly woman with Hodgkin's disease and hepatic involvement but without cholestasis presented with markedly depressed levels of serum esterified cholesterol and high density lipoproteins (HDL). Within five days of her first cycle of chemotherapy her serum HDL-cholesterol rose from 8-10 mg/dl to 88 mg/dl, and level...

journal_title：Cancer investigation

authors： Herbert PN,Friedland ML

更新日期：1986-01-01 00:00:00

abstract：:Radioimmunotherapy (RIT) is a promising new treatment option for patients with relapsed/refractory non-Hodgkin's lymphoma. Clinical trials have demonstrated that both iodine-131 (131I) and yttrium-90 (90Y) are suitable radionuclides for RIT. Iodine-131 and 90Y differ markedly in their physical properties including hal...

journal_title：Cancer investigation

authors： Leonard JP,Siegel JA,Goldsmith SJ

更新日期：2003-04-01 00:00:00

abstract：:Currently, bladder cancer ranks as the second most common genitourinary malignancy which is exacting significant morbidity and mortality worldwide. Although there are abundant epidemiological and basic studies which strongly suggest the role of androgen hormone in bladder cancer, the underlying mechanism is not fully ...

journal_title：Cancer investigation

authors： Wu J,Liu J,Jia R,Song H

更新日期：2013-12-01 00:00:00