Altered Expression of Sphingosine-1-Phosphate Metabolizing Enzymes in Oral Cancer Correlate With Clinicopathological Attributes.


:We have determined the gene expression of sphingosine-1-phosphate (S1P) metabolizing enzymes (SphK1, SphK2, SGPL1, SGPP1, SGPP2, PPAP2A, PPAP2B, and PPAP2C) by quantitative real-time polymerase chain reaction in tumor tissues and adjacent normal tissues of 50 oral squamous cell carcinoma (OSCC) patients. Expression of SphK1 and SGPP1 genes was up-regulated significantly in 70% and 75% OSCC tumors respectively. Importantly, expression of SphK2 and PPAP2B was down-regulated in the tumor tissues of 70% OSCC patients. Expression of SphK2 and PPAP2B negatively correlated with tumor-node-metastasis (TNM) staging and tumor volume respectively. Furthermore, LPP1 is an independent predictor of TNM staging and lymph node ratio.


Cancer Invest


Cancer investigation


Vishwakarma S,Agarwal R,Goel SK,Panday RK,Singh R,Sukumaran R,Khare S,Kumar A




Has Abstract


2017-02-07 00:00:00












  • Phase II trial of ifosfamide, fluorouracil, and folinic acid (FIFO regimen) in relapsed and refractory urothelial cancer.

    abstract::There is no known effective salvage chemotherapy for patients with refractory or relapsed urothelial tumors after methotrexate/cisplatin-based regimen. We report the results of a phase II trial with the FIFO regimen that includes from day 1 to 5: fluorouracil 350 mg/m2, folinic acid 20 mg/m2, and ifosfamide 1000 mg/m2...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章


    authors: Kattan J,Culine S,Theodore C,Droz JP

    更新日期:1995-01-01 00:00:00

  • Lung Cancer in Never-Smoking Women: A Sub-Analysis of the Spanish Female-Specific Database WORLD07.

    abstract::The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed ...

    journal_title:Cancer investigation

    pub_type: 杂志文章,多中心研究


    authors: Viñolas N,Garrido P,Isla D,Provencio M,Majem M,Artal A,Carcereny E,Garcia Campelo R,Lianes P,De La Peñas R,Felip E

    更新日期:2017-05-28 00:00:00

  • Study of the natural history of immunoblastic lymphadenopathy and atypical immunoproliferative disorders.

    abstract::Twenty-three patients, 9 with immunoblastic lymphadenopathy and 14 with atypical immunoproliferative disorders (AIPD), were studied in order to determine their clinical, radiographic, and pathologic features. Diffuse lymphadenopathy was present in all patients. Patients with immunoblastic lymphadenopathy (ILA) had an ...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Lopez-Berestein G,Cabanillas F,Osborne BM,Libshitz HI,Bodey GP

    更新日期:1983-01-01 00:00:00

  • Activated PKCalpha/ERK1/2 signaling inhibits tamoxifen-induced apoptosis in C6 cells.

    abstract::Data have shown that tamoxifen (TAM) can be used to treat not only breast cancer with positive estrogen receptor (ER), but also negative ER including human glioma. However, the molecular mechanism of this drug against different kinds of cancers remains to be elucidated. In this study, we provided the evidence that PKC...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Tian F,Wu H,Li Z,Wang N,Huang J,Li C,Xie F

    更新日期:2009-08-01 00:00:00

  • Examining ethical dilemmas as obstacles to hospice and palliative care for advanced cancer patients.

    abstract::Oncologists deal almost exclusively with patients with serious and life-threatening diseases, many who are terminally ill. While hospice care remains an ideal model of care for cancer patients with life-ending disease, many obstacles are present in the clinical setting that either impede or prevent the otherwise appro...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Daugherty CK

    更新日期:2004-01-01 00:00:00

  • Interferon-α induces G1 cell-cycle arrest in renal cell carcinoma cells via activation of Jak-Stat signaling.

    abstract::The purpose of this study was to clarify the mechanism of IFN-α resistance in RCC. The effects of IFN-α on induction of apoptosis and cell-cycle arrest were analyzed by flow cytometric analysis. Jak-Stat pathway components induced by IFN-α was evaluated using Western blotting. The results suggested that IFN-α caused g...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Shang D,Yang P,Liu Y,Song J,Zhang F,Tian Y

    更新日期:2011-06-01 00:00:00

  • Naturally occurring retroviruses (RNA tumor viruses). I.

    abstract::This is the first of two papers describing the naturally occurring retroviruses (RNA tumor viruses). Here, the general properties of these viruses and the biology of the fish, reptilian, chicken, and mouse retroviruses are described. In the next issue of Cancer Investigation the biologic properties of the cat, cattle,...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Hardy WD Jr

    更新日期:1983-01-01 00:00:00

  • Overexpression of glucose transporter-1 (GLUT-1) predicts poor prognosis in epithelial ovarian cancer.

    abstract::Illumina microarray was used to identify differentially expressed genes in three epithelial ovarian cancer (EOC) cells. To validate the microarray data, mRNA and protein level of glucose transporter-1 (GLUT-1) was examined. GLUT-1 had an EOC/normal cells ratio of 5.51 based on microarray. Real-time PCR and immunohisto...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Cho H,Lee YS,Kim J,Chung JY,Kim JH

    更新日期:2013-11-01 00:00:00

  • Decreased expression and aberrant methylation of Raf kinase inhibitory protein gene in esophageal squamous cell carcinoma.

    abstract::Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas. In the present study, we observed that promoter methylation repressed the expression of RKIP in TE-13 cell line. 5-Aza treatment and stable transfection of RKIP resulted in a significant inhibition ...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Guo W,Dong Z,Lin X,Zhang M,Kuang G,Zhu T

    更新日期:2012-12-01 00:00:00

  • Transgenic nude mouse with green fluorescent protein expression-based human glioblastoma multiforme animal model with EGFR expression and invasiveness.

    abstract::Previously, we developed an orthotopic xenograft model of human glioblastoma multiforme (GBM) with high EGFR expression and invasiveness in Balb/c nu/nu nude mice. Now we also developed the same orthotopic xenograft model in transgenic nude mice with green fluorescent protein (GFP) expression. The present orthotopic x...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Tan GW,Lan FL,Gao JG,Jiang CM,Zhang Y,Huang XH,Ma YH,Shao HD,He XY,Chen JL,Long JW,Xiao HS,Guo ZT,Diao Y

    更新日期:2012-08-01 00:00:00

  • Vinorelbine in combination with interleukin-2 as second-line treatment in patients with metastatic melanoma. A phase II study of the Hellenic Cooperative Oncology Group.

    abstract:OBJECTIVES:To evaluate the efficacy and toxicity of the combination of vinorelbine and interleukin (IL)-2 in patients with metastatic melanoma as second-line chemotherapy. PATIENTS AND METHODS:Twenty-two patients with histologically confirmed stage IV melanoma previously treated with temozolomide-based chemotherapy--o...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Gogas H,Bafaloukos D,Aravantinos G,Fountzilas G,Tsoutsos D,Panagiotou P,Frangia K,Kalofonos HP,Briasoulis E,Castana O,Polyzos A,Pectasides D,Ioannovich J,Hellenic Cooperative Oncology Group.

    更新日期:2004-01-01 00:00:00

  • ErbB receptors as prognostic and therapeutic drug targets in bone and soft tissue sarcomas.

    abstract::ErbB receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ErbB inhibitors are now used in the clinical setting. A large number of studies have been conducted to examine the expression of ErbB family members in bone and soft tissue sarcomas, includi...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Wang H,Yang Q,Fu Z,Zuo D,Hua Y,Cai Z

    更新日期:2014-12-01 00:00:00

  • Intensity modulated arc therapy in bilaterally irradiated head and neck cancer: a comparative and prospective multicenter planning study.

    abstract::A dosimetric comparison was made of Helical Tomotherapy (HT) and Rapid'Arc(®) (RA) in 115 patients with head and neck carcinoma included in a prospective and multicentric study. HT and RA provided highly conformal plans that easily complied with dose volume constraints for organs at risk. HT reduced high doses to the ...

    journal_title:Cancer investigation

    pub_type: 杂志文章,多中心研究


    authors: Vernat SS,Ali D,Messina C,Pommier P,Dussart S,Puyraveau M,Viard R,Lacornerie T,Lisbona A,Fenoglietto P,Mazurier J,Garcia R,Hangard G,Zefkili S,Makovicka L,Giraud P

    更新日期:2014-06-01 00:00:00

  • 5-Aza-2'-deoxycytidine restores proapoptotic function of p53 in cancer cells resistant to p53-induced apoptosis.

    abstract::The expression of p53-target genes encoding the proapoptotic factor Noxa, but not PUMA, was not induced by p53 in HCT116 and SW480 cells, which show resistance to apoptosis in response to p53 overexpression. The lack of p53 inducibility of Noxa was restored by treatment with the DNA methyltransferase inhibitor 5-Aza-2...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Yagi S,Oda-Sato E,Uehara I,Asano Y,Nakajima W,Takeshita T,Tanaka N

    更新日期:2008-08-01 00:00:00

  • Apoptosis in lymphocytic leukemias and lymphomas.

    abstract::Most current classifications of lymphoid neoplasms define the tumors based on the cell of origin, phenotype, genetic abnormalities, and clinical features. Here it is proposed that human lymphocytic tumors can be categorized based on the propensity and capacity of the tumor cells to undergo apoptosis. The first categor...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Schattner EJ

    更新日期:2002-01-01 00:00:00

  • A double-blind, randomized study of two different dosage regimens of intravenous dolasetron in patients receiving high-dose cisplatin chemotherapy.

    abstract::This study compared the antiemetic efficacy and safety of two different intravenous (i.v.) dolasetron dosing regimens in patients receiving their first course of high-dose (> or = 80 mg/m2) cisplatin. Of 30 patients enrolled, 14 received a single i.v. dolasetron dose (0.6 mg/kg) before cisplatin and 16 received a mult...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Kasimis BS,Tapazoglou E,Schulman P,Stewart WH,Hahne WF,Cramer MB

    更新日期:1997-01-01 00:00:00

  • Targeted therapy for renal cell carcinoma: a new therapeutic paradigm.

    abstract::Renal cell carcinoma is the most common tumor of the kidney. It has an unpredictable behavior and poor response to systemic therapy. Developing newer therapy for this disease is a priority considering the high recurrence rate and the small subset of patients who benefit from the use of cytokines such as interferon-alp...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Shaheen PE,Bukowski RM

    更新日期:2006-10-01 00:00:00

  • Methylated tumor-specific DNA as a plasma biomarker in patients with glioma.

    abstract:OBJECTIVE:Patients with systemic malignancies have substantial quantities of tumor-specific DNA in their plasma which may serve as a potential biomarker for tumor burden. This approach has not been studied in gliomas. METHODS:Methylation specific polymerase chain reaction (MSP) was used to determine the methylation st...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Weaver KD,Grossman SA,Herman JG

    更新日期:2006-02-01 00:00:00

  • How should we manage patients with "platinum-sensitive" recurrent ovarian cancer?

    abstract::Decisions about the treatment of recurrent ovarian cancer are usually based on the treatment-free interval. Patients relapsing with an interval of more than six months are usually retreated with platinum-based chemotherapy. Non platinum drugs (such as paclitaxel, gemcitabine, liposomal doxorubicin or topotecan) are al...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Ledermann JA,Wheeler S

    更新日期:2004-01-01 00:00:00

  • Effects of interferon alpha on the expression of p21cip1/waf1 and cell cycle distribution in carcinoid tumors.

    abstract::Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Zhou Y,Wang S,Yue BG,Gobl A,Oberg K

    更新日期:2002-01-01 00:00:00

  • A Pilot Study of Side Effects of Cancer Therapies and their Impact on Satisfaction with Life.

    abstract::This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Kroker L,Dubois C,Münstedt K,Büntzel J,Keinki C,Hübner J

    更新日期:2019-01-01 00:00:00

  • Evaluation of gefitinib for treatment of refractory solid tumors and central nervous system malignancies in pediatric patients.

    abstract::Gefitinib (ZD1839, Iressa), a member of the 4-anilinoquinazoline class of compounds, has the chemical name 4-quinazolinamine, N-(3-chloro-4-flurophenyl)-7-methoxy-6-[3-(4-morpholinyl)propoxy]. Gefitinib often is referred to as a "specific" or "selective" inhibitor of epidermal growth factor receptor (EGFR). EGFR expre...

    journal_title:Cancer investigation

    pub_type: 杂志文章,评审


    authors: Freeman BB 3rd,Daw NC,Geyer JR,Furman WL,Stewart CF

    更新日期:2006-04-01 00:00:00

  • Long-term effects on the intelligence of children treated for acute lymphoblastic leukemia.

    abstract::The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used wa...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Kolotas C,Daniel M,Demetriou L,Martin T,Kurek R,Tonus C,Göbel U,Schnabel T,Zamboglou N

    更新日期:2001-01-01 00:00:00

  • The problem of post-breast cancer lymphedema: impact and measurement issues.

    abstract::Breast cancer treatment is recognized as the most common cause of secondary lymphedema (LE) in the developed countries of the world. LE occurs as both an acute and chronic health condition in which significant and persistent swelling is associated with an abnormal accumulation of protein-rich fluid. The impact of LE i...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Armer JM

    更新日期:2005-01-01 00:00:00

  • Expression of decorin in esophageal cancer in relation to the expression of three isoforms of transforming growth factor-beta (TGF-beta1, -beta2, and -beta3) and matrix metalloproteinase-2 activity.

    abstract::To determine the role of the reactive stroma in cancer progression, we investigated decorin (DCN) and transforming growth factor-beta (TGF-beta expression, and matrix metalloproteinase-2 (MMP-2) activity in the tumorous esophagus. We found statistically insignificantly decreased levels of DCN expression in the patholo...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Augoff K,Grabowski K,Rabczynski J,Kolondra A,Tabola R,Sikorski AF

    更新日期:2009-05-01 00:00:00

  • Prognostic Value of Baseline Neutrophil-to-Lymphocyte Ratio in Outcome of Immune Checkpoint Inhibitors.

    abstract::A meta-analysis of 14 studies (16 cohorts) incorporating 1751 participants was performed to evaluate the correlation between baseline neutrophil-to-lymphocyte ratio (NLR) and outcome of immune checkpoint inhibitors (ICI). The pooled hazard ratio (HR) suggested elevated pretreatment NLR was associated with poor OS (HR:...

    journal_title:Cancer investigation

    pub_type: 杂志文章,meta分析


    authors: Xie X,Liu J,Yang H,Chen H,Zhou S,Lin H,Liao Z,Ding Y,Ling L,Wang X

    更新日期:2019-01-01 00:00:00

  • Nerve growth factor receptor immunoreactivity in breast cancer patients.

    abstract::Nerve growth factor receptor (NGF-R) has been shown to have antiproliferative, differentiative, or apoptotic effects on some types of tumor cells, whereas in others it may have mitogenic activity. The immunohistochemical distribution of NGF-R was analyzed in a series of tissue samples from breast cancer patients and i...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Aragona M,Panetta S,Silipigni AM,Romeo DL,Pastura G,Mesiti M,Cascinu S,La Torre F

    更新日期:2001-01-01 00:00:00

  • Treatment of advanced malignancies with high-dose acetaminophen and N-acetylcysteine rescue.

    abstract::High-dose acetaminophen (HDAC) produces hepatocellular necrosis and cytotoxic changes in other tissues that express mixed-function-oxidase (MFO) activity. N-acetylcysteine (NAC), administered within 8 hr of HDAC exposure, replenishes reduced glutathione and prevents these effects. Numerous cell culture and animal stud...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章


    authors: Kobrinsky NL,Hartfield D,Horner H,Maksymiuk A,Minuk GY,White DF,Feldstein TJ

    更新日期:1996-01-01 00:00:00

  • Phase II evaluation of amonafide in advanced sarcoma: a Southwest Oncology Group study.

    abstract::Soft tissue sarcomas are generally resistant to most chemotherapeutic agents, and individuals with advanced disease have a poor prognosis. We evaluated amonafide, a new drug that has significant activity against several tumor cell lines, to determine its activity against sarcomas. Amonafide was administered to 18 pati...

    journal_title:Cancer investigation

    pub_type: 临床试验,杂志文章,多中心研究


    authors: Buys SS,Metch B,Balcerzak SP,Neefe JR,Stuckey WJ

    更新日期:1994-01-01 00:00:00

  • Triple-negative breast cancer: unique biology and its management.

    abstract::Triple-negative breast cancer is defined by the lack of expression of estrogen-receptor, progesterone-receptor, and HER-2/neu. It primarily, but not exclusively, carries the basal-like molecular profile on gene expression arrays and is associated with BRCA-1 and p53 mutations. It has an aggressive behavior and predile...

    journal_title:Cancer investigation

    pub_type: 杂志文章


    authors: Maegawa RO,Tang SC

    更新日期:2010-10-01 00:00:00