Abstract:
:Triple-negative breast cancer is defined by the lack of expression of estrogen-receptor, progesterone-receptor, and HER-2/neu. It primarily, but not exclusively, carries the basal-like molecular profile on gene expression arrays and is associated with BRCA-1 and p53 mutations. It has an aggressive behavior and predilection for visceral metastasis, therefore accounting for its poor prognosis. Despite lacking targeted therapies, it is sensitive to anthracyclines and taxanes. Increasing knowledge has generated a better understanding of its pathophysiology, therefore leading to the development of directed therapies, although their validation still needs further investigation. This review focuses on its biology, management, evolving concepts, and future directions.
journal_name
Cancer Investjournal_title
Cancer investigationauthors
Maegawa RO,Tang SCdoi
10.3109/07357907.2010.483507subject
Has Abstractpub_date
2010-10-01 00:00:00pages
878-83issue
8eissn
0735-7907issn
1532-4192journal_volume
28pub_type
杂志文章abstract::Platelet-derived growth factor D (PDGF-D) has been shown to mediate cellular processes of importance in cancer progression. This study aimed to investigate the expression and putative involvement of PDGF-D signaling in colorectal carcinogenesis. PDGF-D was expressed in vascular endothelial cells in tumor and normal ti...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1576191
更新日期:2019-01-01 00:00:00
abstract::The WORLD07 study characterizes lung cancer in Spanish women. This analysis investigated lung cancer features in never-smoking women. Of 2072 women recruited, 2035 were analyzed. Patient characteristics and demographics were similar for current/former smokers and never smokers. Among never smokers, 38.3% were exposed ...
journal_title:Cancer investigation
pub_type: 杂志文章,多中心研究
doi:10.1080/07357907.2017.1295461
更新日期:2017-05-28 00:00:00
abstract::Temozolomide is an oral cytotoxic agent that has demonstrated its interest in high grade glioma tumors. This drug can be used either concomitantly with radiotherapy or as chemotherapy. The prognosis of relapsing medulloblastoma is poor and treatment is often difficult, especially after radiotherapy. Here, we report th...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701518164
更新日期:2007-09-01 00:00:00
abstract::Twenty four patients with epithelial ovarian cancer, who were treated by chemotherapy after debulking surgery, were monitored by serial monthly CA125 estimation and half-yearly computerized axial tomogram (CAT) of abdomen and pelvis. The efficiency of these monitoring methods and that of clinical examination were comp...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909009012069
更新日期:1990-01-01 00:00:00
abstract::Serum C-reactive protein (CRP), a sensitive marker of systemic inflammation, has been reported to be associated with the risk of a number of cancers including breast cancer. However, the results are inconsistent. To investigate the association between serum CRP levels and early breast cancer, we conducted a hospital-b...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.789898
更新日期:2013-05-01 00:00:00
abstract::Estrogen-related receptors (ERRs) alpha, beta, and gamma are orphan nuclear receptors that modulate the estrogen signaling pathway and play roles in the regulation of breast cancer cell growth. To determine the association between breast cancer risk and alleles of the tetranucleotide repeat (AAAG)n in the intron of ER...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.845672
更新日期:2013-11-01 00:00:00
abstract::Non-invasive pharmacological management of patients with cancer related pain has resulted in pain control in 90-95% of the patients. Thus, 5-10% of patients still experience inadequate pain control despite aggressive combined pharmacological therapy. Moreover, patients may not tolerate an aggressive program of titrati...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-200027166
更新日期:2004-01-01 00:00:00
abstract::The overexpression of HER-2/neu and p53 has been associated with poor outcome in many neoplasms. Their role in patients with osteosarcoma is unclear. We studied the expression of HER-2/neu and p53 in 22 osteosarcoma samples (from 20 patients--2 had locally recurrent disease) biopsied at the University of Medicine and ...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.1081/cnv-120027577
更新日期:2004-01-01 00:00:00
abstract::Tamoxifen is a first targeted drug that continues to be the gold standard in treatment of estrogen receptor positive breast cancer for almost 50 years. The current review is an update of the paper published in 2012. We provide the new data on the tamoxifen targets that are the key points of signaling cascades activati...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1080/07357907.2018.1453933
更新日期:2018-04-21 00:00:00
abstract::Following is a review of altered fractionation in radiation therapy for head and neck cancer. The goals of altered fractionation are to increase local-regional control and/or reduce the risk of late complications. Altered fractionation schedules can be broadly classified as accelerated fractionation and hyperfractiona...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357909809032890
更新日期:1998-01-01 00:00:00
abstract::Interferon alpha (IFN-alpha) has been shown to produce antitumor effects in 50-80% of carcinoid tumor patients and has demonstrated anti-proliferative effects in carcinoid tumor cells, but the mechanism is not well established. This study presents evidence that in a carcinoid tumor cell line, Bon1, IFN-alpha increases...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120001180
更新日期:2002-01-01 00:00:00
abstract:PURPOSE:Human chondrosarcomas are generally resistant to conventional treatments like chemotherapy and radiotherapy. We investigated the effects of BIBR1532, an inhibitor of telomerase on chondrosarcoma cells in vitro. METHODS:Telomerase activity, telomere lengths, growth kinetics and chemosensitivity were analyzed in...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802072905
更新日期:2008-07-01 00:00:00
abstract::CD147 is highly expressed on many tumor cells; its role for tumor invasiveness and metastasis has been deduced from its capacity to induce MMPs, i.e., MMP-1, -2, -3, and -9. However, in the murine B16 melanoma model, MMP-2/-9 expression occurs independent of CD147. To scrutinize the impact of CD147 on metastasis forma...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900802392675
更新日期:2009-03-01 00:00:00
abstract::Despite increasing evidence of benefit from adjuvant chemotherapy, older women with breast cancer are commonly given less aggressive treatment than younger patients. Conflicting prior data regarding age-related toxicity prompted this prospective study. Forty-four women (aged 35-79 years) with early-stage breast cancer...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357900009012191
更新日期:2000-01-01 00:00:00
abstract::Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression ...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.3109/07357907.2012.681821
更新日期:2012-07-01 00:00:00
abstract::Adjuvant and neoadjuvant chemotherapy is being used increasingly in the treatment of breast cancer patients. However, drug resistance plays an important role in the failure of chemotherapy in breast cancer. The aim of this study was to compare technetium-99m tetrofosmin (Tc-TETRO) mammoscintigraphic findings with the ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-120001147
更新日期:2002-01-01 00:00:00
abstract::Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative a...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1081/cnv-100000069
更新日期:2001-01-01 00:00:00
abstract::This survey aimed at getting a first insight into diverse side effects and their association with satisfaction with life as well as the use of complementary and alternative medicine (CAM) in cancer patients. A total of 100 patients in a German University Hospital were included. General side effects like fatigue, fever...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1625055
更新日期:2019-01-01 00:00:00
abstract::Objectives: We examined the trends in survival based on treatment modality among non-small cell lung cancer (NSCLC) patients in the province of Ontario, Canada, from 2007 to 2015. Methods: We investigated the trends in survival based on treatment modality. Results: Among 56,417 identified patients, the mean age at dia...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2019.1653465
更新日期:2019-01-01 00:00:00
abstract::Studies have demonstrated that plant extracts possess various biological effects including antitumor activity. In the present study, the antitumor activity of Dionysia termeana, a plant native to Iran, was investigated. Cytotoxic activity of the extract on tumor cell lines using MTT colorimetric assay was determined. ...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357900701518487
更新日期:2007-10-01 00:00:00
abstract::Current therapies for glioblastoma multiforme (GBM) are not effective. This study investigated the activity of the M. officinalis essential oil (EO) and its major component (citral) in GBM cell lines. Both EO and citral decreased the viability and induced apoptosis of GBM cells as demonstrated by DNA fragmentation and...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2014.905587
更新日期:2014-07-01 00:00:00
abstract::Cell-free circulating DNAs (cfcDNAs) have been recognized as promising biomarkers for a number of cancers. This study aimed to quantify the cfcDNA in colorectal cancer to assess its potential value as biomarker. Quantification of baseline cfcDNA was determined as the amount of free glyceraldehyde 3-phosphate dehydroge...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.1080/07357907.2017.1408814
更新日期:2017-11-26 00:00:00
abstract::As genetic testing for BRCA1 and BRCA2 (BRCA1/2) mutations is increasingly integrated into the clinical management of high-risk women, it will be important to understand barriers and motivations for genetic counseling among women from underserved minority groups to ensure equitable access to these services. Therefore,...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-58819
更新日期:2005-01-01 00:00:00
abstract::Metronomic chemotherapy refers to the chronic, equally spaced, delivery of low doses of chemotherapeutic drugs, without extended interruptions. Previously, we developed two combined metronomic schemes for the treatment of murine mammary tumors. The aim of this study was to compare their effects on tumor and metastasis...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.877480
更新日期:2014-03-01 00:00:00
abstract::ZBTB7 was recently recognized as a proto-oncogene. We studied its prognostic value and relationship to clinicopathological variables in 125 breast cancer patients. ZBTB7 expression was significantly higher in breast cancer tissues than in normal breast tissues, but its gene amplification copies were relatively low. ZB...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357901003631007
更新日期:2010-07-01 00:00:00
abstract::Targeting the nuclear factor kappa B (NFκB) pathway is proposed as therapy for chronic lymphocytic leukemia (CLL). We hypothesized that an omega-3 fatty acids (n-3) supplement would suppress NFκB activation in lymphocytes of Rai Stage 0-1 CLL patients. The initial dose of 2.4 g n-3/day was gradually increased to 7.2 g...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章
doi:10.3109/07357907.2012.743553
更新日期:2013-01-01 00:00:00
abstract::The results of a prospective trial with a specifically devised chemotherapy regimen in elderly patients with unfavorable non-Hodgkin's lymphoma (NHL) are reported. Between April 1983 and April 1986, 37 consecutive patients 70 years old or more (median age 80) received etoposide and prednimustine (E + P) 100 mg/m2 p.o....
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357909009018923
更新日期:1990-01-01 00:00:00
abstract::Decisions about the treatment of recurrent ovarian cancer are usually based on the treatment-free interval. Patients relapsing with an interval of more than six months are usually retreated with platinum-based chemotherapy. Non platinum drugs (such as paclitaxel, gemcitabine, liposomal doxorubicin or topotecan) are al...
journal_title:Cancer investigation
pub_type: 杂志文章,评审
doi:10.1081/cnv-200030117
更新日期:2004-01-01 00:00:00
abstract::Peroxiredoxins are thiol-specific antioxidant proteins that protect cells from ROS-induced cell death and are elevated in several cancers. We found that five of the six mammalian peroxiredoxins are overexpressed in MCF-7 breast cancer cells at the mRNA and protein levels, compared to noncancerous MCF-10A cells. Inhibi...
journal_title:Cancer investigation
pub_type: 杂志文章
doi:10.3109/07357907.2013.802798
更新日期:2013-07-01 00:00:00
abstract::Standard chemotherapeutic regimens, such as cisplatin and etoposide, may improve quality of life and prolong survival in patients with incurable non-small cell lung cancer (NSCLC). This trial was designed to evaluate the activity and toxicity of a regimen combining three of the most active agents against advanced-stag...
journal_title:Cancer investigation
pub_type: 临床试验,杂志文章,多中心研究
doi:10.3109/07357900009023055
更新日期:2000-01-01 00:00:00