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One-way humoral immune cross-reactivity between bovine spinal cord protein and bovine myelin basic protein.

Abstract：

:Whether bovine myelin basic protein (BP) and bovine spinal cord protein (SCP) cross-react at the humoral immune level was assessed with a sensitive solid-phase enzyme immunoassay. We found that a hyperimmune anti-SCP serum reacted strongly with SCP and cross-reacted nearly as well with BP. A hyperimmune anti-BP serum reacted only with BP. Antigenic competition analysis revealed that SCP and BP both inhibited binding of the hyperimmune anti-SCP serum to solid-phase adsorbed SCP and BP, while only BP inhibited binding of the hyperimmune anti-BP serum to solid-phase adsorbed BP. Finally, BP cross-reactivity antibodies were present in early bleedings from rabbits immunized with SCP that had been passed through an anti-BP immunosorbent column. These results clearly show there is a one-way humoral immune cross-reactivity between SCP and BP which goes in the direction of SCP to BP.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Prokopchuk P,Ziola B,Ramshaw IA,MacPherson CF

doi

10.1016/0161-5890(84)90159-7

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

999-1005

issue

10

eissn

0161-5890

issn

1872-9142

journal_volume

21

pub_type

杂志文章

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