Abstract：
:Mice deficient for SPI-group ETS transcription factors PU.1 or SPI-B fail to generate lymphocytes or do not mount normal antibody mediated immune responses, respectively. PU.1 expression is restricted to B-, T-lymphocytes and macrophages, while SPI-B is expressed in B- and T-lymphocytes. SPI-C is an ETS transcription factor closely related to PU.1 and SPI-B, and expressed temporarily during B-cell development and in macrophages. By deletion and mutation analysis we show that the SPI-C protein has a transactivation domain located to the N-terminus, and that the transactivation activity is reduced to that of the DNA binding domain (DBD) alone when four aspartic acid residues are mutated to alanines. PU.1 and SPI-B regulate transcription from acidic domains located to the N-terminus and by recruiting the co-activator PIP to adjacent sites in a sequence specific manner. In contrast to PU.1 and PIP, SPI-C and PIP were unable to form a distinct ternary complex on the Ig lambda light chain lambda(2-4) enhancer element, suggesting that SPI-C could act both as a positive and negative transcriptional regulator during B-lymphocyte differentiation.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Carlsson R,Persson C,Leanderson Tdoi
10.1016/s0161-5890(03)00032-4subject
Has Abstractpub_date
2003-06-01 00:00:00pages
1035-43issue
16eissn
0161-5890issn
1872-9142pii
S0161589003000324journal_volume
39pub_type
杂志文章abstract：:Purified mRNA's encoding the HLA-A and -B antigen heavy chains or beta 2-microglobulin were prepared from human B lymphoid cells by positive hybridization selection procedures. The role of chain association in the biosynthesis and intracellular transport of HLA-A and -B antigens was investigated by injecting these mRN...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1986-05-01 00:00:00
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journal_title：Molecular immunology
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更新日期：1985-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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journal_title：Molecular immunology
pub_type： 杂志文章
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journal_title：Molecular immunology
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.04.003
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pub_type： 杂志文章
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：2007-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2018.12.013
更新日期：2019-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
doi：10.1016/s0161-5890(99)00118-2
更新日期：1999-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2019.07.007
更新日期：2019-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(95)00092-5
更新日期：1995-10-01 00:00:00
abstract：:The translation of mRNA within total RNA of German (Blattella germanica) cockroaches was performed using a rabbit reticulocyte lysate system. Analysis of the translation products by SDS-PAGE and combined autoradiography revealed several synthesized proteins with apparent molecular weights ranging from 20 kD to 110 kD....
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(93)90443-f
更新日期：1993-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2007.12.010
更新日期：2008-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2016-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2008.04.012
更新日期：2008-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1996-02-01 00:00:00
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pub_type： 杂志文章
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更新日期：2019-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1998-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：1992-04-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2020-08-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2006.09.033
更新日期：2007-03-01 00:00:00
abstract：:Maspin (mammary serine protease inhibitor) is a non-inhibitory member of the serine protease inhibitor superfamily and a tumor suppressor in several cancers due to its ability to inhibit cell invasion, angiogenesis, and promote apoptosis. However, its immunomodulatory function remains largely unexplored. Thus, we expl...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2016.12.021
更新日期：2017-02-01 00:00:00
abstract：:Leucine-rich repeat-containing G-protein-coupled receptors (LGRs) form a subfamily of the large superfamily of G-protein-coupled receptors. LGRs can be divided into three groups. LGR2 from Drosophila melanogaster is involved in cuticle tanning (melanization and sclerotization). In this study, one LGR2 (MnLGR2) was ide...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2020.07.013
更新日期：2020-10-01 00:00:00
abstract：:Peptide binding to major histocompatibility complex (MHC) class II molecules is optimal at mildly acidic pH. X-ray crystal structures solved for the murine class II molecule I-E(k) revealed an interesting localization of negatively charged residues within the P6 pocket, which may have implications in the pH dependency...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(02)00010-x
更新日期：2002-06-01 00:00:00
abstract：:The mechanism by which heparin inhibits the alternative complement pathway (ACP) by a fluid-phase activator, CoVF, has been studied. Results presented here indicate that heparin's major (rate-limiting) effect on the fluid-phase activation of the ACP was to potentiate Factor H activity. Such an effect results in a very...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(83)90139-6
更新日期：1983-11-01 00:00:00
