Abstract:
:A transplanted organ suffers inherently from an ischaemic insult and subsequent reperfusion injury. The severity of such early events is thought to influence the success of the transplant procedure, not only in the immediate post-transplant period, but also to predispose the graft to both acute and chronic rejection. In this paper, we review the influence of the complement system upon ischaemia,reperfusion injury. The recognition of the involvement of complement has led to novel strategies to try to modulate ischaemia/reperfusion injury, some of which we have summarized. Finally, we note our own strategy to target complement inhibition in ischaemic tissues.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Dong J,Pratt JR,Smith RA,Dodd I,Sacks SHdoi
10.1016/s0161-5890(99)00118-2subject
Has Abstractpub_date
1999-09-01 00:00:00pages
957-63issue
13-14eissn
0161-5890issn
1872-9142journal_volume
36pub_type
杂志文章,评审abstract::IFN-gamma plays an essential role in the IL-12/IL-23/IFN-gamma pathway that is required for the defense against intracellular pathogens. In the IFN-gammaR1 several amino acid substitutions have been reported that abrogate IFN-gamma signaling. These substitutions can lead to a null phenotype and enhanced susceptibility...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2009.11.016
更新日期:2010-02-01 00:00:00
abstract::PKZ, protein kinase containing Z-DNA binding domains, is a novel member of eIF2α kinase in fish. PKZ can be up-regulated in response to Poly I:C or heat stress, and it has a typical eIF2α kinase activity. However, the relationship between fish PKZ and apoptosis remains unclear. In the present study, effects of PKZ on ...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2015.11.006
更新日期:2016-01-01 00:00:00
abstract::Trichosanthin (TCS) is a type I ribosome-inactivating protein with wide spectrum of pharmacological activities. It inhibits human immunodeficiency virus type 1 (HIV-1) and Herpes simplex virus type 1 (HSV-1) replication but the mechanism is not clear. From a previous study, TCS was found to be more cytotoxic to HIV-1 ...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2011.06.217
更新日期:2011-09-01 00:00:00
abstract::The binding properties of 18 monoclonal antibodies (MAbs) directed against the tobacco mosaic virus (TMV) coat protein were studied with five related tobamoviruses and seven mutant viruses, as well as with the dissociated coat proteins of these variants. Ten of the antibodies bound to both TMV and TMV protein, but the...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(87)90131-3
更新日期:1987-12-01 00:00:00
abstract::Most of the complement proteins in circulation are, by and large, synthesized in the liver. However data accumulated over the past several decades provide incontrovertible evidence that some if not most of the individual complement proteins are also synthesized extrahepatically by activated as well as non-activated ce...
journal_title:Molecular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.molimm.2016.11.003
更新日期:2017-04-01 00:00:00
abstract::The globular C1q heterotrimer is a subunit of the C1 complement factor. Binding of the C1q subunit to the constant (Fc) part of antibody molecules is a first step and key event of complement activation. Although three-dimensional structures of C1q and antibody Fc subunits have been determined experimentally no atomic ...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2012.02.111
更新日期:2012-05-01 00:00:00
abstract::The myobacterial factors and the associated mechanism by which Mycobacterium tuberculosis (Mtb) evades the host immune surveillance system remain widely unexplored. Here, we found that overexpressing Rv1016c, a mannosylated protein of M. tuberculosis in BCG (rBCG-Rv1016c) led to increased virulence of the recombined B...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2019.02.021
更新日期:2019-05-01 00:00:00
abstract::The developmental regulation of antigen receptor gene transcription and recombination are mediated by cis regulatory elements. At the T cell receptor beta chain locus (TCRbeta), two DNase I hypersensitive sites within the Jbeta2-Cbeta2 intron contained binding sites for NF-kappaB and additional nuclear factors and wer...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(01)00031-1
更新日期:2001-01-01 00:00:00
abstract::Integrin-mediated adhesion of human monocytes to fibrinogen regulated by CD11b/CD18 and the closely related integrin CD11c/CD18, play a key role in inflammation. Peripheral blood monocytes isolated from human donors despite expressing CD11c primarily utilized CD11b to mediate adhesion to fibrinogen upon stimulation wi...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2008.04.021
更新日期:2008-08-01 00:00:00
abstract::C-reactive protein (CRP) is an acute-phase protein featuring a homopentameric structure and Ca-binding specificity for phosphocholine (PCh). Expression of CRP is regulated mainly at the transcriptional level with interleukin-6 being the principal inducer of the gene during the acute phase. The crystal structure of CRP...
journal_title:Molecular immunology
pub_type: 杂志文章,评审
doi:10.1016/s0161-5890(01)00042-6
更新日期:2001-08-01 00:00:00
abstract::Binding of the catecholamine beta-adrenergic antagonist, l-alprenolol, by the IgGl anti-alprenolol monoclonal antibody 37A4 was examined using the radioligand 3H-dihydroalprenolol as an extrinsic signal and the increase in antibody fluorescence upon l-alprenolol binding as intrinsic signal. Equilibrium binding studies...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(87)90043-5
更新日期:1987-06-01 00:00:00
abstract::Four cell lines producing monoclonal antibodies were obtained by fusion of NS1 myeloma cells with splenocytes of BALB/C mice immunized with only 1 microgram of each staphylococcal enterotoxin A, B, C1 and D by a modified technique of intrasplenic boosting. This procedure was considerably more efficient than the more c...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(87)90118-0
更新日期:1987-12-01 00:00:00
abstract::Conjugates of monoclonal antibodies and Pseudomonas exotoxin A (PE) were formed with disulfide or thioether bonds. Thioether conjugates which formed with succinimidyl 4-(N-maleimidomethyl)-cyclohexane-1-carboxylate (SMCC) modified PE and reduced antibody formed with an 80% yield of equimolar conjugate within 30 min wi...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(90)90140-u
更新日期:1990-03-01 00:00:00
abstract::Emerging evidence has indicated that vascular endothelial cells (ECs) not only form the barrier between blood and the vessel wall but also serve as conditional innate immune cells. Our previous study found that SIRT1, a class III histone deacetylase, inhibits the inflammatory response in ECs. Recent studies revealed t...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2016.07.018
更新日期:2016-09-01 00:00:00
abstract::Surfactant protein D (SP-D) interacts with various different microorganisms and plays an important role in pulmonary innate immunity. SP-D expression has also been detected in extrapulmonary tissues, including the gastro-intestinal tract. However, its function in the intestine is unknown and may differ considerably fr...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2007.03.013
更新日期:2007-07-01 00:00:00
abstract::Using a combinatorial chemistry approach, we identified a tetrameric tripeptide, denoted Protein A Mimetic (PAM) or TG19318, able to bind to immunoglobulins of different classes and species. The inverso variant, with the tripeptide in the all-D configuration (D-PAM or TG19320), is described as retaining binding proper...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2007.04.020
更新日期:2008-01-01 00:00:00
abstract::The purpose of this study was to evaluate the effects of GATA-6 on airway inflammation and remodeling and the underlying mechanisms in a murine model of chronic asthma. Female BALB/c mice were randomly divided into four groups: phosphate-buffered saline control (PBS), ovalbumin (OVA)-induced asthma group (OVA), OVA+ s...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2016.05.017
更新日期:2016-07-01 00:00:00
abstract:BACKGROUND:Tumor necrosis factor-α (TNF-α) is involved in inflammatory responses in atherosclerosis. We propose an in vitro cellular assay to evaluate the anti-inflammatory mechanisms of potential modifiers such as food extracts. In the current model we assessed an anti-inflammatory effect of polyphenol-rich peanut ext...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2012.05.007
更新日期:2012-10-01 00:00:00
abstract::Clonal idiotypic immunoglobulins of follicular lymphomas can be isolated by somatic fusion procedures. Idiotypic IgMs (Id-IgM) were isolated from two patients and used to immunise a strain of mice, deficient in mouse antibody production and engineered with yeast artificial chromosomes (YAC) containing fragments of the...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2004.03.035
更新日期:2004-07-01 00:00:00
abstract::Accumulating evidence suggests a role for the complement system in the pathogenesis of diabetes and the vascular complications that characterise this condition. Complement proteins contribute to the development of type 1 diabetes (T1D) by enhancing the underlying organ-specific autoimmune processes. Complement upregul...
journal_title:Molecular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.molimm.2019.07.031
更新日期:2019-10-01 00:00:00
abstract::Tumors exploit immunoregulatory checkpoints that serve to attenuate T cell responses as a means of circumventing immunologic rejection. Programmed death ligand 1 (PD-L1) is a negative regulator of T cell function and is frequently expressed by solid tumors. By engaging programmed death 1 (PD-1) on activated T cells, P...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2012.03.023
更新日期:2012-07-01 00:00:00
abstract::It is widely believed that migrating immune cells utilise the intercellular junctions as routes of passage, and in doing so cause the transient disruption of junctional structures. Thus there is much interest in the molecules that have been identified at cell-cell contact points and their potential involvement in the ...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(99)00122-4
更新日期:1999-12-01 00:00:00
abstract::Arginine kinase (AK) is a panallergen present in crustaceans, which can induce an immunoglobulin (Ig) E-mediated immune response in humans. The aim of this work was to map and characterize the antigenic epitopes of Scylla paramamosain AK. Specific-protein-A-enriched IgG raised in rabbits against purified S. paramamosa...
journal_title:Molecular immunology
pub_type: 临床试验,杂志文章
doi:10.1016/j.molimm.2015.02.010
更新日期:2015-06-01 00:00:00
abstract::We report that the protein tyrosine phosphatase PTP-PEST is expressed in resting human and mouse CD4(+) and CD8(+) T cells, but not in Jurkat T leukemia cells, and that PTP-PEST protein, but not mRNA, was dramatically downregulated in CD4(+) and CD8(+) primary human T cells upon T cell activation. This was also true i...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2008.03.019
更新日期:2008-06-01 00:00:00
abstract::The analysis of the antigenic structure of human interferon (IFN)-alpha 1 with a panel of monoclonal antibodies revealed four immunodominant regions. Three of them, recognized by 12 of 14 antibodies were mapped into the aminoterminal portion of IFN-alpha 1 around residues 31-38, 43-53 and 63-85. The region 31-85 prove...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(92)90124-g
更新日期:1992-07-01 00:00:00
abstract::Linear IgE-binding epitopes identified in legumin allergens of peanut (Ara h 3) and other allergenic tree nuts (Jug r 4 of walnut, Cor a 9 of hazelnut, Ana o 2 cashew nut) were mapped on three-dimensional models of the proteins built up by homology modelling. A conformational analysis revealed that consensual surface-...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2007.01.023
更新日期:2007-05-01 00:00:00
abstract::Triptolide has been used extensively in China for the treatment of autoimmune diseases and tumor for many centuries. Nevertheless, little is known about its exact immunosuppressive and anti-inflammatory properties. Increasing recognition of the importance of renal tubular epithelial cells (TECs) in renal diseases rais...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2005.07.026
更新日期:2006-03-01 00:00:00
abstract::An important function of Fcγ receptors is the removal of IgG-containing immune complexes from the circulation. The activating receptor FcγRIIA and inhibitory receptor FcγRIIB2 are both expressed on human myeloid cells, and are both capable of mediating endocytosis of immune complexes. We studied endocytosis of these t...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/j.molimm.2011.09.003
更新日期:2011-10-01 00:00:00
abstract::N-substituted benzamides are compounds that have recently been reported to inhibit nuclear factor-kappaB (NF-kappaB) activity and induce apoptosis in a pre-B cell line. In this study, we focused on the effects of N-substituted benzamides on transcriptional regulation in Jurkat T cells. We used a model system where the...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/s0161-5890(01)00060-8
更新日期:2001-08-01 00:00:00
abstract::In order to improve our knowledge of the human immunoglobulin variable lambda locus (IGLV), we mapped one cosmid clone (designated as C40.2) isolated by screening a Colo320HSR genomic library. The 34 kb insert of the C40.2 clone was shown to contain six genes. One gene, IGLV2S1, belongs to the V lambda II subgroup. Fo...
journal_title:Molecular immunology
pub_type: 杂志文章
doi:10.1016/0161-5890(94)90175-9
更新日期:1994-06-01 00:00:00