Strategies for targeting complement inhibitors in ischaemia/reperfusion injury.

Abstract:

:A transplanted organ suffers inherently from an ischaemic insult and subsequent reperfusion injury. The severity of such early events is thought to influence the success of the transplant procedure, not only in the immediate post-transplant period, but also to predispose the graft to both acute and chronic rejection. In this paper, we review the influence of the complement system upon ischaemia,reperfusion injury. The recognition of the involvement of complement has led to novel strategies to try to modulate ischaemia/reperfusion injury, some of which we have summarized. Finally, we note our own strategy to target complement inhibition in ischaemic tissues.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Dong J,Pratt JR,Smith RA,Dodd I,Sacks SH

doi

10.1016/s0161-5890(99)00118-2

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

957-63

issue

13-14

eissn

0161-5890

issn

1872-9142

journal_volume

36

pub_type

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