Homology analysis and cross-immunogenicity of OmpA from pathogenic Yersinia enterocolitica, Yersinia pseudotuberculosis and Yersinia pestis.

abstract：:A recent publication in Molecular Immunology by Leo and Goldman doi:10.1016/j.molimm.2009.02.024 has shown that the Escherichia coli immunoglobulin-binding (Eib) proteins are receptors for IgG and IgA. We would like to highlight important issues that were not addressed in their recent manuscript whilst providing possi...

journal_title：Molecular immunology

authors： Pleass RJ

更新日期：2009-07-01 00:00:00

abstract：:In two recent articles published in Molecular Immunology, Steere and colleagues continue their search for an autoimmune mechanism of arthritis in patients who have failed short-course antibiotic therapy for Borrelia burgdorferi, the spirochetal agent of Lyme disease. As in previous attempts, the authors fail to elucid...

journal_title：Molecular immunology

authors： Stricker RB,Johnson L

更新日期：2008-06-01 00:00:00

abstract：:We investigated the antibody (Ab) and cytotoxic T lymphocyte (CTL) responses to gene gun (GG)-mediated DNA immunization via the intramuscular (i.m.) and intradermal (i.d.) routes. BALB/c mice were immunized five times at weekly intervals with plasmid DNA encoding enhanced green fluorescent protein (EGFP). EGFP product...

journal_title：Molecular immunology

authors： Ito K,Ito K,Shinohara N,Kato S

更新日期：2003-05-01 00:00:00

abstract：:Toll-like receptors (TLR) are expressed on the surface or intracellularly by dendritic cells (DC) and recognize specifically different pathogen-associated molecular patterns (PAMPs). Increasing evidence suggests that TLR expressed by DC can cooperate to synergize their functions. Here, we describe the cooperation of T...

journal_title：Molecular immunology

authors： Theiner G,Rössner S,Dalpke A,Bode K,Berger T,Gessner A,Lutz MB

更新日期：2008-01-01 00:00:00

abstract：:An efficient method is described for the isolation of highly purified, IgG-free and stable guinea-pig serum C1q. The procedure includes the chromatography of EDTA-treated serum (25 mM EDTA) on CM- and DEAE-cellulose followed by gel filtration on ACA 34-Ultrogel whereby ammonium sulfate precipitation was used for conce...

journal_title：Molecular immunology

authors： Hitschold T,Golan MD,Rabs U,Loos M

更新日期：1983-02-01 00:00:00

abstract：:In Drosophila the synthesis of antimicrobial peptides in response to microbial infections is under the control of the Toll and immune deficiency (Imd) signaling pathways. The Toll signaling pathway responds mainly to Gram-positive bacterial and fungal infection while the Imd pathway mediates the response to Gram-negat...

journal_title：Molecular immunology

authors： Leone P,Bischoff V,Kellenberger C,Hetru C,Royet J,Roussel A

更新日期：2008-05-01 00:00:00

abstract：:The interaction between a single-chain Fv (sFv) of the monoclonal antibody 3A21 and its antigen, bovine pancreatic ribonuclease A (RNase A), was studied by site-directed mutagenesis of the hypervariable regions and fluorescence polarization analysis. The affinity constants of wild-type sFv and a mutant sFv D31A (Asp31...

journal_title：Molecular immunology

authors： Katakura Y,Kumamoto T,Iwai Y,Kurokawa Y,Omasa T,Suga K

更新日期：1997-07-01 00:00:00

abstract：:Monoclonal antibodies (MAbs) raised against trout immunoglobulin (Ig) recognize two independent Ig populations differing in the molecular weight of L chains. The trout Ig population recognized by MAb 2H9 represented congruent to 20% of the total Ig and contained L chains congruent to 26 kDa, whereas the trout Ig popul...

journal_title：Molecular immunology

authors： Sánchez C,Domínguez J

更新日期：1991-11-01 00:00:00

abstract：:Viral myocarditis (VMC) is an inflammation of the myocardium closely associated with Coxsackievirus B3 (CVB3) infection. Vγ1+γδT cells, one of early cardiac infiltrated innate population, were reported to protect CVB3 myocarditis while the precise mechanism not fully addressed. To explore cytokine profiles and kinetic...

journal_title：Molecular immunology

authors： Wan F,Yan K,Xu D,Qian Q,Liu H,Li M,Xu W

更新日期：2017-01-01 00:00:00

abstract：:MHC class I molecules present short peptides, usually 8-10 amino acids in length, to CD8(+) T cells. These peptides are typically generated from full-length endogenously synthesized proteins degraded by the antigen processing machinery of the target cell. However, exogenous proteins, whether originating from intracell...

journal_title：Molecular immunology

authors： Wolf BJ,Princiotta MF

更新日期：2011-01-01 00:00:00

abstract：:Evidence has been accumulating for a role of inflammation in the development of Alzheimer's disease (AD), a progressive neurodegenerative disorder causing a common form of dementia in the elderly. C1q, part of the initiation component of the classical complement pathway (CCP), is associated with beta-sheet, fibrillar ...

journal_title：Molecular immunology

authors： Li M,Ager RR,Fraser DA,Tjokro NO,Tenner AJ

更新日期：2008-06-01 00:00:00

abstract：:The effectiveness of immunotherapy targeting the immune checkpoint PD-L1/PD-1 pathway highlights importance of elucidating the regulatory mechanisms of PD-L1 expression in cancer cells. Previous studies demonstrate that oncogene MYC up-regulates PD-L1 expression in lymphomas. In the present study, we investigated the ...

journal_title：Molecular immunology

authors： Zou J,Zhuang M,Yu X,Li N,Mao R,Wang Z,Wang J,Wang X,Zhou H,Zhang L,Shi Y

更新日期：2018-09-01 00:00:00

abstract：:Mannose-binding lectin (MBL) is a recognition molecule of the complement (C) system and binds to carbohydrate ligands present on a wide range of pathogenic bacteria, viruses, fungi, and parasites. MBL has been detected in the cervico-vaginal cavity where it can provide a first-line defence against infectious agents co...

journal_title：Molecular immunology

authors： Bulla R,De Seta F,Radillo O,Agostinis C,Durigutto P,Pellis V,De Santo D,Crovella S,Tedesco F

更新日期：2010-11-01 00:00:00

abstract：:In this study we constructed two phage libraries displaying non-immunized natural human IgM derived HCDR3 repertoires. One library was structurally constrained by a Gly to Cys substitution at position 104 enabling the formation of a disulfide bridge with the Cys at position 92. Panning of these libraries on an anti-hu...

journal_title：Molecular immunology

authors： Deroo S,Fischer A,Beaupain N,Counson M,Boutonnet N,Pletinckx J,Loverix S,Beirnaert E,De Haard H,Schmit JC,Lasters I

更新日期：2008-03-01 00:00:00

abstract：:We have previously developed a number of monoclonal antibodies (Mabs) that bind to protamine. One of these antibodies, Hup1N, binds to human protamine 1 but not to protamine 2. In contrast, Mab HupA binds both protamine 1 and protamine 2. The epitopes for these two Mabs were observed to overlap, and were localized to ...

journal_title：Molecular immunology

authors： Stanker LH,Wyrobek A,McKeown C,Balhorn R

更新日期：1993-12-01 00:00:00

abstract：:The transcription factor NF-kappaB plays critical roles in immune and inflammatory responses. Here we show that filarial parasitic sheath proteins cause activation of NF-kappaB in the airway epithelial HEp-2 cell line. This activation was transient and saturable, and involved degradation of the cytoplasmic inhibitor p...

journal_title：Molecular immunology

authors： Narayanan K,Balakrishnan A,Miyamoto S

更新日期：2000-02-01 00:00:00

abstract：:Histocompatibility Leukocyte Antigens, or HLAs, are one of the most polymorphic molecules in humans. This high degree of polymorphism endows HLA molecules with the ability to present a vast array of peptides, an essential trait for responding to ever-evolving pathogens. Unlike classical HLA molecules (HLA-Ia), some no...

journal_title：Molecular immunology

authors： Grant EJ,Nguyen AT,Lobos CA,Szeto C,Chatzileontiadou DSM,Gras S

更新日期：2020-04-01 00:00:00

abstract：:BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhib...

journal_title：Molecular immunology

authors： Swiecki M,Omattage NS,Brett TJ

更新日期：2013-06-01 00:00:00

abstract：:Major histocompatibility complex (MHC) class I and II proteins have been in the focus of interest for immunologists, biochemists, cell biologists, and structural biologists for decades. With dozens of entries in the Protein Data Bank, their crystal structures are now sufficiently well understood, while their dynamic p...

journal_title：Molecular immunology

authors： Yaneva R,Schneeweiss C,Zacharias M,Springer S

更新日期：2010-01-01 00:00:00

abstract：:Sialic acid - binding immunoglobulin - like lectins (Siglecs) are members of the largest superfamily of immune receptors; they recognize sialic acid and are mainly expressed in immune cells. Studies on mammals indicate that Streptococcus agalactiae (GBS) evade immune reactions by interacting with the host immune cells...

journal_title：Molecular immunology

authors： Dong J,Wei Y,Ye X,Sun C,Tian Y,Lu M,Du J,Chen Z

更新日期：2016-05-01 00:00:00

abstract：:Vitamin D has been recommended as an immune modulator in recent years, in addition to regulating calcium-phosphorous-bone metabolism. Clinical studies on organ transplantation found that vitamin D sufficiency patients were less likely to develop acute cellular rejection within one year after transplantation compared t...

journal_title：Molecular immunology

authors： Zhou Q,Qin S,Zhang J,Zhon L,Pen Z,Xing T

更新日期：2017-11-01 00:00:00

abstract：:Interleukin (IL)-23 is a heterodimeric cytokine composed of the IL-23-specific subunit p19 and the p40 subunit which also constitutes part of IL-12. IL-23 propagates development of Th17 cells, a novel T cell subset which produces IL-17 but no interferon-gamma or IL-4. For both, IL-23 and IL-23-driven IL-17, a crucial ...

journal_title：Molecular immunology

authors： Sender LY,Gibbert K,Suezer Y,Radeke HH,Kalinke U,Waibler Z

更新日期：2010-03-01 00:00:00

abstract：:The O-antigen of the gram negative bacteria Brucella is composed of an homopolymer of 4,6-dideoxy-4-formamido-alpha-D-mannopyranosyl (or perosamine). Several mAb interact specifically with only the O-antigen of certain Brucella species. Although, many studies show that this specific recognition results mainly from the...

journal_title：Molecular immunology

authors： Laurent TC,Mertens P,Dierick JF,Letesson JJ,Lambert C,De Bolle X

更新日期：2004-03-01 00:00:00

abstract：:Selection of specific antibodies from large repertoires is of importance in generating antibodies to specific structural determinants and in studying structure-function relationships. Alkaline phosphatase (AP) has several isozymes with various degrees of homology and a range of common synthetic substrates. We have pre...

journal_title：Molecular immunology

authors： Jain V,Saini D,Goswami P,Sinha S

更新日期：2007-01-01 00:00:00

abstract：:Mycobacterium tuberculosis (M.tb) infects 8 million and kills 2.2 million people each year worldwide. M.tb modulates the immune response of the infected individual. Empirically, suppressor carbohydrates (SC) produced by CD8+ T cells in response to M.tb were found to induce a T helper 2 response rather than a protectiv...

journal_title：Molecular immunology

authors： Smit van Dixhoorn MG,Munir R,Sussman G,Stad R,de Haan M,van der Hoeven T,Rauwerda H,Breit TM,Thallinger GG,Wadee AA

更新日期：2008-03-01 00:00:00

abstract：:CD4+CD25+ natural Treg cells, which are developed in the thymus, migrate to the periphery to actively maintain self-tolerance. Similar to conventional T cells, TCR signals are critical for the development and activation of Treg cell inhibitory function. While PKC-theta-mediated TCR signals are required for the activat...

journal_title：Molecular immunology

authors： Gupta S,Manicassamy S,Vasu C,Kumar A,Shang W,Sun Z

更新日期：2008-12-01 00:00:00

abstract：:Aging is an irreversible physiological process characterized by increased risk of diseases, reduced effectiveness of vaccines, and decreased immune responses. One of the most prominent paradigms of aging and age related conditions is the progressive accumulation of un-repaired DNA breaks leading to apoptosis and exhau...

journal_title：Molecular immunology

authors： Puthiyaveetil AG,Caudell DL

更新日期：2013-01-01 00:00:00

abstract：:Recent studies suggest that CD8(+) T cells with down-regulated CD8 expression (CD3(+)CD8(low) T cells) represented as a distinct phenotype of CD8(+) T cells are increased and linked to disease severity in some chronically persistent infection, such as chronic HIV and parasite infection. However, the role of CD3(+)CD8(...

journal_title：Molecular immunology

authors： Ouyang L,Li X,Liang Z,Yang D,Gong F,Shen G,Weng X,Wu X

更新日期：2013-12-01 00:00:00

abstract：:Many T cell responses are dominated by restricted TCR expression and can range from repeated usage of particular TCR Vbeta- and/or Valpha-elements, to the preferential usage of both V- and J-elements, often in conjunction with conserved V-D-J or V-J junctional sequences. Cytotoxic T lymphocytes specific for a Kb-restr...

journal_title：Molecular immunology

authors： Turner SJ,Carbone FR

更新日期：1998-04-01 00:00:00

abstract：:Radioimmunochemical studies on the comparison of the immunological cross-reactivity between the 7-S Igs of birds, reptiles and amphibians (IgY-like Igs) and the IgA of mammals (man and pig) using 125I-chicken IgY and anti-chicken IgY(Fc) or anti-chicken IgY(H) antibodies from rabbits and carp for the detection led to ...

journal_title：Molecular immunology

authors： Hädge D,Ambrosius H

更新日期：1984-08-01 00:00:00