Abstract：
:CD4+CD25+ natural Treg cells, which are developed in the thymus, migrate to the periphery to actively maintain self-tolerance. Similar to conventional T cells, TCR signals are critical for the development and activation of Treg cell inhibitory function. While PKC-theta-mediated TCR signals are required for the activation of peripheral naïve T cells, they are dispensable for their thymic development. Here, we show that mice deficient in PKC-theta had a greatly reduced number of CD4+Foxp3+ Treg cells, which was independent of PKC-theta-regulated survival, as transgenic Bcl-x(L) could not restore the Treg cell population in PKC-theta(-/-) mice. Active and WT PKC-theta markedly stimulated, whereas inactive PKC-theta and dominant negative NFAT inhibited Foxp3 promoter activity. In addition, mice-deficient in calcineurin Abeta had a decreased Treg cell population, similar to that observed in PKC-theta deficient mice. It is likely that PKC-theta promoted the development of Treg cells by enhancing Foxp3 expression via activation of the calcineurin/NFAT pathway. Finally, Treg cells deficient in PKC-theta were as potent as WT Treg cells in inhibiting T cell activation, indicating that PKC-theta was not required for Treg cell-mediated inhibitory function. Our data highlight the contrasting roles PKC-theta plays in conventional T cell and natural Treg cell function.
journal_name
Mol Immunoljournal_title
Molecular immunologyauthors
Gupta S,Manicassamy S,Vasu C,Kumar A,Shang W,Sun Zdoi
10.1016/j.molimm.2008.08.275subject
Has Abstractpub_date
2008-12-01 00:00:00pages
213-24issue
2eissn
0161-5890issn
1872-9142pii
S0161-5890(08)00650-0journal_volume
46pub_type
杂志文章abstract：:IFN-gamma plays an essential role in the IL-12/IL-23/IFN-gamma pathway that is required for the defense against intracellular pathogens. In the IFN-gammaR1 several amino acid substitutions have been reported that abrogate IFN-gamma signaling. These substitutions can lead to a null phenotype and enhanced susceptibility...
journal_title：Molecular immunology
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2010-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1999-12-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2017-01-01 00:00:00
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pub_type： 杂志文章
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更新日期：2016-09-01 00:00:00
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pub_type： 杂志文章
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更新日期：2004-03-01 00:00:00
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更新日期：1995-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：2010-07-01 00:00:00
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pub_type： 杂志文章
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更新日期：1988-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/0161-5890(91)90088-2
更新日期：1991-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.11.020
更新日期：2010-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2012.07.001
更新日期：2013-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2019.01.018
更新日期：2019-03-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2019.04.010
更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章
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更新日期：1982-05-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2009.10.020
更新日期：2010-01-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2012-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2009-10-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2011-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1987-02-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2003-09-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：2012-07-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/j.molimm.2008.02.022
更新日期：2008-06-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2004-11-01 00:00:00
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journal_title：Molecular immunology
pub_type： 杂志文章,评审
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更新日期：2019-06-01 00:00:00
abstract：:The ability of bovine IgG preparations to bind to the various distinct human leukocyte Fc gamma receptors was studied. In experiments using intact cells and isolated Fc gamma receptors, it was demonstrated that bovine IgG can bind to Fc gamma receptors of four human cell types but not to Fc gamma receptors of human ne...
journal_title：Molecular immunology
pub_type： 杂志文章
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更新日期：1987-03-01 00:00:00
abstract：:Previous work on the cis-acting elements that control heavy chain variable region (VH) gene somatic hypermutation has indicated the presence of an as yet unidentified element(s) 3' of the intron enhancer that is necessary for high rate mutation. Examination of cis-acting elements involved in kappa light chain V gene h...
journal_title：Molecular immunology
pub_type： 杂志文章
doi：10.1016/s0161-5890(97)00065-5
更新日期：1997-04-01 00:00:00
