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BST-2/tetherin: structural biology, viral antagonism, and immunobiology of a potent host antiviral factor.

Abstract：

:BST-2 (also known as tetherin, CD317, or HM1.24) was first described as a potent interferon-inducible host antiviral factor nearly five years ago. Since that time, numerous reports have been published regarding the antiviral activity and immunological properties of this protein. BST-2 blocks viral replication by inhibiting enveloped virus budding from the surface of infected cells. To counteract this, most viruses have developed strategies to antagonize BST-2, each employing a unique mechanism. In this review, we summarize the antiviral function, structural biology and immunobiology of BST-2. Taken together, our current understanding of BST-2 suggests potential avenues as well as challenges to exploiting its action in the development of broad spectrum antiviral treatments.

journal_name

Mol Immunol

journal_title

Molecular immunology

authors

Swiecki M,Omattage NS,Brett TJ

doi

10.1016/j.molimm.2012.11.008

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

132-9

issue

2

eissn

0161-5890

issn

1872-9142

pii

S0161-5890(12)00466-X

journal_volume

54

pub_type

杂志文章,评审

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